PMID- 30327610
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 9
DP  - 2018
TI  - Daily Intermittent Normobaric Hypoxia Over 2 Weeks Reduces BDNF Plasma Levels in 
      Young Adults - A Randomized Controlled Feasibility Study.
PG  - 1337
LID - 10.3389/fphys.2018.01337 [doi]
LID - 1337
AB  - Background: The results from animal and human research indicate that acute 
      intermittent hypoxia can enhance brain-derived neurotrophic factor (BDNF) plasma 
      levels and gene expression. As BDNF is known to promote the differentiation of 
      new neurons and the formation of synapses, it has been proposed to mediate adult 
      neuroplasticity. Thus, the present study aimed to analyze the long-term effects 
      of daily intermittent exposure to normobaric hypoxia (simulating high altitude 
      exposure at approximately 4000-5000 m) over 2 weeks on BDNF levels in young 
      adults. Methods: Twenty-eight young adults (age: 19-33 years) were randomized 
      into a hypoxic intervention group (N = 14) or the control group (N = 14). 
      Participants in the intervention group breathed intermittent normobaric hypoxic 
      air at resting conditions (5 min intervals, 80-85% SpO(2) measured via a finger 
      pulse oximeter, 12 sessions for 60 min/day for 2 weeks) via a hypoxic generator. 
      BDNF plasma and serum levels were determined at baseline and at 2 weeks after 
      intervention using sandwich ELISAs. Results: After 2 weeks of daily intermittent 
      hypoxic treatment (IHT), we found a significant group x time interaction effect 
      for BDNF plasma levels based on a significant decrease in BDNF levels in the 
      hypoxia group. Conclusion: Our results demonstrate that daily intermittent 
      administration of hypoxic air has a significant effect on BDNF regulation in 
      healthy young adults. Contrary to other results reporting an increase in BDNF 
      levels under hypoxic conditions, the present data suggest that hypoxic treatment 
      using intensive IHT can reduce BDNF plasma levels for at least 2 weeks. This 
      finding indicates that the daily application of hypoxic air is too frequent for 
      the aimed physiological response, namely, an increase in BDNF levels.
FAU - Becke, Andreas
AU  - Becke A
AD  - Institute of Cognitive Neurology and Dementia Research, 
      Otto-von-Guericke-Universitat Magdeburg, Magdeburg, Germany.
AD  - Neuroprotection Laboratory, German Center for Neurodegenerative Diseases (DZNE), 
      Magdeburg, Germany.
FAU - Muller, Patrick
AU  - Muller P
AD  - Neuroprotection Laboratory, German Center for Neurodegenerative Diseases (DZNE), 
      Magdeburg, Germany.
FAU - Dordevic, Milos
AU  - Dordevic M
AD  - Neuroprotection Laboratory, German Center for Neurodegenerative Diseases (DZNE), 
      Magdeburg, Germany.
FAU - Lessmann, Volkmar
AU  - Lessmann V
AD  - Institute of Physiology, Otto-von-Guericke-Universitat Magdeburg, Magdeburg, 
      Germany.
AD  - Center for Behavioral Brain Sciences, Magdeburg, Germany.
FAU - Brigadski, Tanja
AU  - Brigadski T
AD  - Institute of Physiology, Otto-von-Guericke-Universitat Magdeburg, Magdeburg, 
      Germany.
AD  - Informatics and Microsystem Technology, University of Applied Sciences, 
      Kaiserslautern, Kaiserslautern, Germany.
FAU - Muller, Notger G
AU  - Muller NG
AD  - Neuroprotection Laboratory, German Center for Neurodegenerative Diseases (DZNE), 
      Magdeburg, Germany.
AD  - Center for Behavioral Brain Sciences, Magdeburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20181001
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC6174219
OTO - NOTNLM
OT  - BDNF
OT  - IHT
OT  - adaptation
OT  - hypoxia
OT  - neuroplasticity
EDAT- 2018/10/18 06:00
MHDA- 2018/10/18 06:01
PMCR- 2018/10/01
CRDT- 2018/10/18 06:00
PHST- 2018/06/18 00:00 [received]
PHST- 2018/09/04 00:00 [accepted]
PHST- 2018/10/18 06:00 [entrez]
PHST- 2018/10/18 06:00 [pubmed]
PHST- 2018/10/18 06:01 [medline]
PHST- 2018/10/01 00:00 [pmc-release]
AID - 10.3389/fphys.2018.01337 [doi]
PST - epublish
SO  - Front Physiol. 2018 Oct 1;9:1337. doi: 10.3389/fphys.2018.01337. eCollection 
      2018.