PMID- 30327684
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 1756-2856 (Print)
IS  - 1756-2864 (Electronic)
IS  - 1756-2856 (Linking)
VI  - 11
DP  - 2018
TI  - Effect of the combination of motor imagery and electrical stimulation on upper 
      extremity motor function in patients with chronic stroke: preliminary results.
PG  - 1756286418804785
LID - 10.1177/1756286418804785 [doi]
LID - 1756286418804785
AB  - BACKGROUND: The combination of motor imagery (MI) and afferent input with 
      electrical stimulation (ES) enhances the excitability of the corticospinal tract 
      compared with motor imagery alone or electrical stimulation alone. However, its 
      therapeutic effect is unknown in patients with hemiparetic stroke. We performed a 
      preliminary examination of the therapeutic effects of MI + ES on upper extremity 
      (UE) motor function in patients with chronic stroke. METHODS: A total of 10 
      patients with chronic stroke demonstrating severe hemiparesis participated. The 
      imagined task was extension of the affected finger. Peripheral nerve electrical 
      stimulation was applied to the radial nerve at the spiral groove. MI + ES 
      intervention was conducted for 10 days. UE motor function as assessed with the 
      Fugl-Meyer assessment UE motor score (FMA-UE), the amount of the affected UE use 
      in daily life as assessed with a Motor Activity Log (MAL-AOU), and the degree of 
      hypertonia in flexor muscles as assessed with the Modified Ashworth Scale (MAS) 
      were evaluated before and after intervention. To assess the change in spinal 
      neural circuits, reciprocal inhibition between forearm extensor and flexor 
      muscles with the H reflex conditioning-test paradigm at interstimulus intervals 
      (ISIs) of 0, 20, and 100 ms were measured before and after intervention. RESULTS: 
      UE motor function, the amount of the affected UE use, and muscle hypertonia in 
      flexor muscles were significantly improved after MI + ES intervention (FMA-UE: p 
      < 0.01, MAL-AOU: p < 0.01, MAS: p = 0.02). Neurophysiologically, the intervention 
      induced restoration of reciprocal inhibition from the forearm extensor to the 
      flexor muscles (ISI at 0 ms: p = 0.03, ISI at 20 ms: p = 0.03, ISI at 100 ms: p = 
      0.01). CONCLUSION: MI + ES intervention was effective for improving UE motor 
      function in patients with severe paralysis.
FAU - Okuyama, Kohei
AU  - Okuyama K
AD  - Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Ogura, Miho
AU  - Ogura M
AD  - Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Kawakami, Michiyuki
AU  - Kawakami M
AD  - Department of Rehabilitation Medicine, Keio University School of Medicine, 35 
      Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
FAU - Tsujimoto, Kengo
AU  - Tsujimoto K
AD  - Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Okada, Kohsuke
AU  - Okada K
AD  - Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Miwa, Kazuma
AU  - Miwa K
AD  - Department of Rehabilitation Medicine, Keio University Hospital, Tokyo, Japan.
FAU - Takahashi, Yoko
AU  - Takahashi Y
AD  - Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Abe, Kaoru
AU  - Abe K
AD  - Department of Rehabilitation Medicine, Keio University Hospital, Tokyo, Japan.
FAU - Tanabe, Shigeo
AU  - Tanabe S
AD  - Faculty of Rehabilitation, School of Health Sciences, Fujita Health University, 
      Toyoake-shi, Aichi, Japan.
FAU - Yamaguchi, Tomofumi
AU  - Yamaguchi T
AD  - Department of Physical Therapy, Yamagata Prefectural University of Health 
      Sciences, Yamagata-shi, Yamagata, Japan.
FAU - Liu, Meigen
AU  - Liu M
AD  - Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20181009
PL  - England
TA  - Ther Adv Neurol Disord
JT  - Therapeutic advances in neurological disorders
JID - 101480242
PMC - PMC6178123
OTO - NOTNLM
OT  - cerebrovascular disease
OT  - electrical stimulation
OT  - hemiparesis
OT  - motor imagery
OT  - rehabilitation
COIS- Conflict of interest statement: The authors declare that there is no conflict of 
      interest.
EDAT- 2018/10/18 06:00
MHDA- 2018/10/18 06:01
PMCR- 2018/10/09
CRDT- 2018/10/18 06:00
PHST- 2018/02/14 00:00 [received]
PHST- 2018/08/01 00:00 [accepted]
PHST- 2018/10/18 06:00 [entrez]
PHST- 2018/10/18 06:00 [pubmed]
PHST- 2018/10/18 06:01 [medline]
PHST- 2018/10/09 00:00 [pmc-release]
AID - 10.1177_1756286418804785 [pii]
AID - 10.1177/1756286418804785 [doi]
PST - epublish
SO  - Ther Adv Neurol Disord. 2018 Oct 9;11:1756286418804785. doi: 
      10.1177/1756286418804785. eCollection 2018.