PMID- 30327865
OWN - NLM
STAT- MEDLINE
DCOM- 20191001
LR  - 20191001
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 38
IP  - 12
DP  - 2018 Dec
TI  - Systemic lupus erythematosus and antineutrophilic cytoplasmic antibody-associated 
      vasculitis overlap syndrome complicated by subarachnoid hemorrhage: case-based 
      review.
PG  - 2329-2335
LID - 10.1007/s00296-018-4169-z [doi]
AB  - Systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic 
      antibody-associated vasculitis (AAV) overlap syndrome is an inflammatory disorder 
      with a mixed presentation that is characterized by clinical features of both SLE 
      and AAV. Although renal disease predominates, any organ system in the body may be 
      affected. Neurologic manifestation in patients with SLE-AAV overlap syndrome is 
      rare and has only been previously documented as cerebral ischemia. We report a 
      patient with SLE-AAV overlap syndrome diagnosed based on clinical, serologic and 
      biopsy-proven histologic findings who presented with subarachnoid hemorrhage 
      (SAH) secondary to ruptured right anterior cerebral artery aneurysm. To the 
      authors' knowledge, this is the first reported case of SLE-AAV overlap syndrome 
      diagnosed in a patient with a SAH due to an intracranial aneurysm. Neurologic 
      involvement in patients with SLE-AAV overlap syndrome is uncommon and has not 
      been well-studied. Clinicians who encounter patients with neurologic signs that 
      present with symptoms and a serologic profile that correspond to both SLE and AAV 
      criteria, should consider the association between SLE-AAV overlap syndrome and a 
      hemorrhagic stroke, specifically SAH.
FAU - Khorolsky, Ciril
AU  - Khorolsky C
AUID- ORCID: 0000-0002-1062-9131
AD  - Department of Medicine, NYU Langone Health, 550 First Avenue, New York, NY, 
      10016, USA. Ciril.Khorolsky@nyulangone.org.
FAU - Castellano, Andrew
AU  - Castellano A
AUID- ORCID: 0000-0002-1038-0647
AD  - Department of Medicine, NYU Langone Health, 550 First Avenue, New York, NY, 
      10016, USA.
FAU - Comstock, David
AU  - Comstock D
AUID- ORCID: 0000-0003-3657-237X
AD  - Department of Medicine, NYU Langone Health, 550 First Avenue, New York, NY, 
      10016, USA.
FAU - Brinster, Nooshin K
AU  - Brinster NK
AUID- ORCID: 0000-0002-9731-4115
AD  - Department of Pathology, NYU Langone Health, 550 First Avenue, New York, NY, 
      10016, USA.
FAU - See, Sein Y
AU  - See SY
AUID- ORCID: 0000-0002-8511-9048
AD  - Department of Nephrology, NYU Langone Health, 550 First Avenue, New York, NY, 
      10016, USA.
FAU - Garner, Bruce F
AU  - Garner BF
AUID- ORCID: 0000-0002-9531-1295
AD  - Department of Rheumatology, NYU Langone Health, 550 First Avenue, New York, NY, 
      10016, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20181016
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Biomarkers)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adrenal Cortex Hormones/administration & dosage
MH  - Adult
MH  - Aneurysm, Ruptured/diagnostic imaging/*etiology
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/blood/*complications/diagnosis/therapy
MH  - Antibodies, Antineutrophil Cytoplasmic/blood
MH  - Biomarkers/blood
MH  - Biopsy
MH  - Cerebral Angiography
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/administration & dosage
MH  - Intracranial Aneurysm/*complications/diagnostic imaging
MH  - Lupus Erythematosus, Systemic/blood/*complications/diagnosis/therapy
MH  - Plasma Exchange
MH  - Subarachnoid Hemorrhage/diagnostic imaging/*etiology
MH  - Syndrome
MH  - Treatment Outcome
OTO - NOTNLM
OT  - ANCA-associated vasculitis
OT  - Lupus
OT  - Overlap syndrome
OT  - Subarachnoid hemorrhage
EDAT- 2018/10/18 06:00
MHDA- 2019/10/02 06:00
CRDT- 2018/10/18 06:00
PHST- 2018/06/23 00:00 [received]
PHST- 2018/10/01 00:00 [accepted]
PHST- 2018/10/18 06:00 [pubmed]
PHST- 2019/10/02 06:00 [medline]
PHST- 2018/10/18 06:00 [entrez]
AID - 10.1007/s00296-018-4169-z [pii]
AID - 10.1007/s00296-018-4169-z [doi]
PST - ppublish
SO  - Rheumatol Int. 2018 Dec;38(12):2329-2335. doi: 10.1007/s00296-018-4169-z. Epub 
      2018 Oct 16.