PMID- 30328241
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20190311
IS  - 1532-2998 (Electronic)
IS  - 1532-3005 (Linking)
VI  - 35
IP  - 1
DP  - 2019 Feb
TI  - Mindfulness-based program for stress reduction in infertile women: Randomized 
      controlled trial.
PG  - 49-58
LID - 10.1002/smi.2839 [doi]
AB  - Infertile women often experience chronic stress, which may have a negative impact 
      on general well-being and may increase the burden of infertility. In this 
      open-label, parallel, randomized controlled trial, infertile women aged 
      18-50 years (median 37 years) were assigned to an 8-week mindfulness-based 
      program (MBP) or no intervention. The primary outcome was stress severity 
      measured by the Lipp's Stress Symptoms Inventory (ISSL). Data were analyzed by 
      modified intent-to-treat principle, which included all cases available to 
      follow-up regardless of adherence to the intervention (62 participants from the 
      MBP group and 37 from the control group). The median number of symptoms of 
      chronic stress recorded in the past month decreased from six (interquartile range 
      2 to 9) before the MBP to two (interquartile range 1 to 4) after the intervention 
      (p < 0.001, repeated measures analysis of variance with Time x Group 
      interaction). Depressive symptoms also decreased after MBP, whereas general 
      well-being improved (p < 0.01 for both outcomes). Hair cortisol and serum 
      brain-derived neurotrophic factor (BDNF) did not change significantly between 
      preintervention and postintervention. None of the outcomes changed significantly 
      in the control group. MBP was effective in reducing stress and depressive 
      symptoms while increasing general well-being in infertile women.
CI  - (c) 2018 John Wiley & Sons, Ltd.
FAU - Nery, Simone F
AU  - Nery SF
AD  - Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, 
      Belo Horizonte, Brazil.
FAU - Paiva, Sara P C
AU  - Paiva SPC
AD  - Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, 
      Belo Horizonte, Brazil.
FAU - Vieira, Erica L
AU  - Vieira EL
AD  - Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo 
      Horizonte, Brazil.
FAU - Barbosa, Andressa B
AU  - Barbosa AB
AD  - Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, 
      Belo Horizonte, Brazil.
FAU - Sant'Anna, Edna M
AU  - Sant'Anna EM
AD  - Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, 
      Belo Horizonte, Brazil.
FAU - Casalechi, Maira
AU  - Casalechi M
AD  - Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, 
      Belo Horizonte, Brazil.
FAU - Dela Cruz, Cynthia
AU  - Dela Cruz C
AD  - Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, 
      Belo Horizonte, Brazil.
FAU - Teixeira, Antonio L
AU  - Teixeira AL
AD  - Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo 
      Horizonte, Brazil.
AD  - Department of Psychiatry and Behavioral Sciences, University of Texas Health 
      Science Center at Houston, Houston, Texas.
FAU - Reis, Fernando M
AU  - Reis FM
AUID- ORCID: 0000-0002-9258-7472
AD  - Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, 
      Belo Horizonte, Brazil.
LA  - eng
GR  - 465482/2014-7/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20181016
PL  - England
TA  - Stress Health
JT  - Stress and health : journal of the International Society for the Investigation of 
      Stress
JID - 101089166
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Brazil
MH  - Depression/*therapy
MH  - Female
MH  - Hair/chemistry
MH  - Humans
MH  - Hydrocortisone/chemistry
MH  - Infertility, Female/*psychology
MH  - Middle Aged
MH  - *Mindfulness
MH  - Psychiatric Status Rating Scales
MH  - Quality of Life
MH  - Stress, Psychological/*therapy
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - BDNF
OT  - cortisol
OT  - depression
OT  - infertility
OT  - mindfulness
OT  - quality of life
OT  - stress
EDAT- 2018/10/18 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/10/18 06:00
PHST- 2018/04/17 00:00 [received]
PHST- 2018/05/30 00:00 [revised]
PHST- 2018/09/16 00:00 [accepted]
PHST- 2018/10/18 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/10/18 06:00 [entrez]
AID - 10.1002/smi.2839 [doi]
PST - ppublish
SO  - Stress Health. 2019 Feb;35(1):49-58. doi: 10.1002/smi.2839. Epub 2018 Oct 16.