PMID- 30328478
OWN - NLM
STAT- MEDLINE
DCOM- 20190225
LR  - 20200225
IS  - 1432-1971 (Electronic)
IS  - 0172-0643 (Linking)
VI  - 40
IP  - 1
DP  - 2019 Jan
TI  - Relationship Between Serum B7-H3 Levels and Prognosis of Congenital Heart Disease 
      in Children.
PG  - 177-181
LID - 10.1007/s00246-018-1975-8 [doi]
AB  - The aim of this study was to investigate the role of B7-H3 in prognosis of 
      congenital heart disease (CHD) children patients. A total of 65 CHD patients 
      within age 3-12 years who went to our hospital were included during August 2011 
      to December 2012. Demographic data including age, sex, weight, clinical basic 
      information such as New York Heart Association (NYHA) class, pathological type 
      were collected. Blood samples were collected and serum levels of B7-H3, 
      C-reactive protein (CRP), N-Terminal Pro-Brain Natriuretic Peptide (NT-pro-BNP), 
      and High-sensitivity Troponin T (hsTnT) were determined by enzyme-linked 
      immunosorbent assay (ELISA). Characteristics including age, gender, weight, 
      pathological type, NYHA class, and serum levels of hsTnT and CRP showed no 
      significant difference between deceased and survival patients. However, serum 
      levels of B7-H3 and NT-pro-BNP were significantly higher in deceased patients 
      compared survival patients. Patients with high expressed B7-H3 had higher risks 
      for total major cardiovascular events (MACE) occurrence compared with the lower 
      group. Among the MACE events, significant difference was observed in rates of 
      death, new onset of arrhythmias, and surgical, but not in NYHA class worsening 
      and percutaneous intervention. Patients with higher levels if B7-H3 had 
      significantly higher risk for mortality in the 5-year follow-up compared with the 
      lower group, logic analysis was also conducted and results showed that B7-H3 
      might be an independent risk factor for 5-year mortality for CHD patients. B7-H3 
      was up-regulated in dead CHD patients, and serum levels of B7-H3 were related to 
      long-term MACE and 5-year mortality of CHD patients.
FAU - Zhang, Rufang
AU  - Zhang R
AD  - Department of Cardiothoracic Surgery, Shanghai Children's Hospital, Shanghai Jiao 
      Tong University, No. 335, Luding Road, Putuo District, Shanghai, 200062, China. 
      zrf7391@21cn.com.
FAU - Gong, Jin
AU  - Gong J
AD  - Department of Cardiothoracic Surgery, Shanghai Children's Hospital, Shanghai Jiao 
      Tong University, No. 335, Luding Road, Putuo District, Shanghai, 200062, China.
FAU - Wang, Shouqing
AU  - Wang S
AD  - Department of Surgery, Huai'an City Women and Children's Hospital, Huai'an, 
      Jiangsu, China.
FAU - Shen, Li
AU  - Shen L
AD  - Department of Cardiothoracic Surgery, Shanghai Children's Hospital, Shanghai Jiao 
      Tong University, No. 335, Luding Road, Putuo District, Shanghai, 200062, China.
FAU - Xie, Yewei
AU  - Xie Y
AD  - Department of Cardiothoracic Surgery, Shanghai Children's Hospital, Shanghai Jiao 
      Tong University, No. 335, Luding Road, Putuo District, Shanghai, 200062, China.
FAU - Li, Xiaobing
AU  - Li X
AD  - Department of Cardiothoracic Surgery, Shanghai Children's Hospital, Shanghai Jiao 
      Tong University, No. 335, Luding Road, Putuo District, Shanghai, 200062, China.
LA  - eng
PT  - Journal Article
DEP - 20181017
PL  - United States
TA  - Pediatr Cardiol
JT  - Pediatric cardiology
JID - 8003849
RN  - 0 (B7 Antigens)
RN  - 0 (Biomarkers)
RN  - 0 (CD276 protein, human)
RN  - 0 (Peptide Fragments)
RN  - 0 (Troponin T)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - B7 Antigens/*blood
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Heart Defects, Congenital/blood/genetics/*mortality
MH  - Humans
MH  - Male
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Prognosis
MH  - Risk Factors
MH  - Troponin T/blood
OTO - NOTNLM
OT  - B7-H3
OT  - Children
OT  - Congenital heart disease
OT  - Prognosis
EDAT- 2018/10/18 06:00
MHDA- 2019/02/26 06:00
CRDT- 2018/10/18 06:00
PHST- 2018/05/10 00:00 [received]
PHST- 2018/08/29 00:00 [accepted]
PHST- 2018/10/18 06:00 [pubmed]
PHST- 2019/02/26 06:00 [medline]
PHST- 2018/10/18 06:00 [entrez]
AID - 10.1007/s00246-018-1975-8 [pii]
AID - 10.1007/s00246-018-1975-8 [doi]
PST - ppublish
SO  - Pediatr Cardiol. 2019 Jan;40(1):177-181. doi: 10.1007/s00246-018-1975-8. Epub 
      2018 Oct 17.