PMID- 30329132
OWN - NLM
STAT- MEDLINE
DCOM- 20200825
LR  - 20200825
IS  - 1469-994X (Electronic)
IS  - 1462-2203 (Linking)
VI  - 22
IP  - 2
DP  - 2020 Feb 6
TI  - Is Brain-Derived Neurotrophic Factor Associated With Smoking Initiation? 
      Replication Using a Large Finnish Population Sample.
PG  - 293-296
LID - 10.1093/ntr/nty218 [doi]
AB  - INTRODUCTION: Brain-derived neurotrophic factor (BDNF) is a growth factor in the 
      central nervous system. There is evidence for the involvement of BDNF in 
      addictions and mental disorders. We aimed to replicate the earlier reported 
      association of a functional genetic variant of BDNF with smoking initiation (SI) 
      using a large population-based sample and to test whether the association is 
      independent of depression. METHODS: Our sample was drawn from the Finnish 
      population-based FINRISK surveys conducted in 1992, 1997, 2002, and 2007. We had 
      nonmissing data on the genotype BDNF  Val66Met (G/A) variant (rs6265) and 
      self-reported never (n = 10 619) versus ever (n = 16 028) smoking among 26 647 
      adults aged 25-74 years. The association between BDNF  Val66Met and SI was 
      modeled using logistic regression adjusted for age and sex, and in secondary 
      analyses also for depression. Depression was defined as self-reported depression 
      diagnosed or treated by physician during the past year. RESULTS: The sex- and 
      age-adjusted analysis confirmed that the major (Val) allele increased the risk of 
      being a lifetime ever smoker (per allele odds ratio [OR] = 1.07; 95% CI = 1.01 to 
      1.12; p = .01). When depression, which itself was significantly associated with 
      SI (OR = 1.58; 95% CI = 1.37 to 1.82; p < .001), was added to the model, the 
      association of the gene with SI remained significant (per allele OR = 1.06; 95% 
      CI = 1.01 to 1.12; p = .01). Exclusion of depressed individuals did not change 
      the results (OR = 1.06; 95% CI = 1.01 to 1.12; p = .02). CONCLUSIONS: In a 
      Finnish population sample, we replicated the earlier reported association of BDNF 
      Val66Met with SI. Our data further suggest that this association is independent 
      of depression. IMPLICATIONS: Earlier finding about the association between the 
      BDNF gene and smoking initiation is replicated and shown to be independent of 
      depression within Finnish adult population.
CI  - (c) The Author(s) 2018. Published by Oxford University Press on behalf of the 
      Society for Research on Nicotine and Tobacco. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Korhonen, Tellervo
AU  - Korhonen T
AD  - Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 
      Helsinki, Finland.
AD  - Department of Public Health, University of Helsinki, Helsinki, Finland.
AD  - National Institute of Health and Welfare, Helsinki, Finland.
FAU - Loukola, Anu
AU  - Loukola A
AD  - Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 
      Helsinki, Finland.
FAU - Hallfors, Jenni
AU  - Hallfors J
AD  - Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 
      Helsinki, Finland.
FAU - Salomaa, Veikko
AU  - Salomaa V
AD  - National Institute of Health and Welfare, Helsinki, Finland.
FAU - Kaprio, Jaakko
AU  - Kaprio J
AD  - Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 
      Helsinki, Finland.
AD  - Department of Public Health, University of Helsinki, Helsinki, Finland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nicotine Tob Res
JT  - Nicotine & tobacco research : official journal of the Society for Research on 
      Nicotine and Tobacco
JID - 9815751
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Behavior, Addictive/epidemiology/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Depressive Disorder/*epidemiology/*genetics
MH  - Female
MH  - Finland/epidemiology
MH  - Genetic Predisposition to Disease/epidemiology/genetics
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - *Population Surveillance/methods
MH  - Tobacco Smoking/*epidemiology/*genetics
MH  - Valine/genetics
MH  - Young Adult
EDAT- 2018/10/18 06:00
MHDA- 2020/08/26 06:00
CRDT- 2018/10/18 06:00
PHST- 2018/07/05 00:00 [received]
PHST- 2018/10/12 00:00 [accepted]
PHST- 2018/10/18 06:00 [pubmed]
PHST- 2020/08/26 06:00 [medline]
PHST- 2018/10/18 06:00 [entrez]
AID - 5133430 [pii]
AID - 10.1093/ntr/nty218 [doi]
PST - ppublish
SO  - Nicotine Tob Res. 2020 Feb 6;22(2):293-296. doi: 10.1093/ntr/nty218.