PMID- 30329194
OWN - NLM
STAT- MEDLINE
DCOM- 20190528
LR  - 20210109
IS  - 1600-0714 (Electronic)
IS  - 0904-2512 (Print)
IS  - 0904-2512 (Linking)
VI  - 48
IP  - 2
DP  - 2019 Feb
TI  - Aberrant histone modification and inflammatory cytokine production of peripheral 
      CD4+ T cells in patients with oral lichen planus.
PG  - 136-142
LID - 10.1111/jop.12790 [doi]
AB  - BACKGROUNDS: To investigate alterations in histone modification and histone 
      deacetylases (HDACs) in patients with oral lichen planus (OLP), and to evaluate 
      correlations with inflammatory cytokine production. METHODS: Global histone H3/H4 
      acetylation and HDAC activity in CD4+ T cells from 23 patients with OLP and 10 
      healthy control subjects were examined using spectrophotometry. The mRNA levels 
      of eight members of four classes of HDAC genes were measured by real-time 
      quantitative polymerase chain reaction. Forty cytokines involved in inflammation 
      were examined with a cytokine array. The correlation between histone modification 
      and cytokine production was analyzed. RESULTS: Global histone H3 hypo-acetylation 
      was observed in OLP patients. Patients with OLP had significantly higher HDACs 
      activity,and higher HDAC6 and HDAC7 mRNA level compared with the controls. Of the 
      40 cytokines in the cytokine array, eight were significantly increased in OLP 
      patients: interleukin (IL)-4, IL-8, IL-1ra, tumor necrosis factor receptor II 
      (TNFR II), macrophage inflammatory protein 1b (MIP-1b), fibrosis-associated 
      tissue inhibitors of metalloproteinase 1 (TIMP)-1, monocyte chemotactic protein 1 
      (MCP-1), and eotaxin-2. In the OLP group, the acetylation level of histone H3 was 
      negatively correlated with IL-4 and MCP-1 production, and the expression of HDAC6 
      mRNA was positively correlated with MCP-1 production. In the non-erosive 
      subgroup, acetylation of histone H3 was negatively correlated with IL-4, IL-16, 
      and TIMP-2 production. In the erosive OLP subgroup, the expression of HDAC7 mRNA 
      was positively correlated with MIP-1a production. CONCLUSION: Aberrant histone 
      modification of CD4+ T cells in peripheral blood could occur in OLP patients, and 
      possibly affects inflammatory cytokine production.
CI  - (c) 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Shen, Jun
AU  - Shen J
AD  - Department of Oral Medicine, Stomatological Hospital, Southern Medical 
      University, Guangzhou, Guangdong, China.
FAU - Yin, Cao
AU  - Yin C
AD  - Department of Oral Medicine, Stomatological Hospital, Southern Medical 
      University, Guangzhou, Guangdong, China.
FAU - Jiang, Xiao
AU  - Jiang X
AD  - Department of Oral Medicine, Stomatological Hospital, Southern Medical 
      University, Guangzhou, Guangdong, China.
FAU - Wang, Xuan
AU  - Wang X
AD  - Department of Oral Medicine, Stomatological Hospital, Southern Medical 
      University, Guangzhou, Guangdong, China.
FAU - Yang, Shujuan
AU  - Yang S
AD  - Department of Oral Pathology, Stomatological Hospital, Southern Medical 
      University, Guangzhou, Guangdong, China.
FAU - Song, Guangbao
AU  - Song G
AUID- ORCID: 0000-0002-3081-9899
AD  - Department of Oral Medicine, Stomatological Hospital, Southern Medical 
      University, Guangzhou, Guangdong, China.
LA  - eng
GR  - A2016207/Guangdong Medical Science and Technology Research Fund/
PT  - Journal Article
DEP - 20181108
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - EC 3.5.1.98 (Histone Deacetylases)
SB  - IM
MH  - Acetylation
MH  - Adult
MH  - CD4-Positive T-Lymphocytes/enzymology/*immunology/*metabolism
MH  - Cytokines/*metabolism
MH  - Female
MH  - *Histone Code
MH  - Histone Deacetylases/metabolism
MH  - Humans
MH  - Inflammation Mediators/*metabolism
MH  - Lichen Planus, Oral/*genetics/*immunology
MH  - Male
MH  - Middle Aged
PMC - PMC6588086
OTO - NOTNLM
OT  - T cell
OT  - acetylation
OT  - cytokine
OT  - histone modification
OT  - oral lichen planus
COIS- The authors declared that they have no conflict of interest.
EDAT- 2018/10/18 06:00
MHDA- 2019/05/29 06:00
PMCR- 2019/06/21
CRDT- 2018/10/18 06:00
PHST- 2018/07/26 00:00 [received]
PHST- 2018/09/05 00:00 [revised]
PHST- 2018/10/11 00:00 [accepted]
PHST- 2018/10/18 06:00 [pubmed]
PHST- 2019/05/29 06:00 [medline]
PHST- 2018/10/18 06:00 [entrez]
PHST- 2019/06/21 00:00 [pmc-release]
AID - JOP12790 [pii]
AID - 10.1111/jop.12790 [doi]
PST - ppublish
SO  - J Oral Pathol Med. 2019 Feb;48(2):136-142. doi: 10.1111/jop.12790. Epub 2018 Nov 
      8.