PMID- 30332612
OWN - NLM
STAT- MEDLINE
DCOM- 20181226
LR  - 20211204
IS  - 1872-7786 (Electronic)
IS  - 0009-2797 (Linking)
VI  - 296
DP  - 2018 Dec 25
TI  - Taurine attenuates OTA-promoted PCV2 replication through blocking ROS-dependent 
      autophagy via inhibiting AMPK/mTOR signaling pathway.
PG  - 220-228
LID - S0009-2797(18)30988-8 [pii]
LID - 10.1016/j.cbi.2018.10.005 [doi]
AB  - Previous research found that ochratoxin A (OTA) could promote PCV2 replication by 
      inducing autophagy. The aim of this study is to evaluate the effect of dietary 
      amino acid derivative taurine on OTA-promoted PCV2 replication and explore the 
      underlying mechanism. The results showed that taurine could inhibit OTA-promoted 
      PCV2 replication in PK-15 cells. The effect of taurine could be mediated by its 
      ability to attenuate ROS level and block OTA-promoted autophagy. Indeed, 
      induction of autophagy by rapamycin could suppress the inhibitory effect of 
      taurine on OTA-promoted PCV2 replication. Furthermore, taurine supplementation 
      inhibited 5'AMP-activated protein kinase (AMPK) and activated mammalian target of 
      rapamycin (mTOR). Activation of AMPK by acadesine (AICAR) could suppress the 
      effect of taurine. In conclusion, taurine treatment suppresses autophagy by 
      regulating the ROS/AMPK/mTOR signaling axis, thereby inhibiting OTA-promoted PCV2 
      replication. These findings provide the rationale for the use of taurine as an 
      intervention against PCV2 infection.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Zhai, Nianhui
AU  - Zhai N
AD  - College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, 
      Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in 
      Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, 
      Jiangsu Province, China.
FAU - Wang, Hong
AU  - Wang H
AD  - College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, 
      Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in 
      Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, 
      Jiangsu Province, China.
FAU - Chen, Ying
AU  - Chen Y
AD  - College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, 
      Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in 
      Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, 
      Jiangsu Province, China.
FAU - Li, Hu
AU  - Li H
AD  - College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, 
      Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in 
      Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, 
      Jiangsu Province, China.
FAU - Viktor, Korolchuk
AU  - Viktor K
AD  - Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle 
      upon Tyne, NE4 5PL, UK.
FAU - Huang, Kehe
AU  - Huang K
AD  - College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, 
      Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in 
      Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, 
      Jiangsu Province, China.
FAU - Chen, Xingxiang
AU  - Chen X
AD  - College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, 
      Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in 
      Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, 
      Jiangsu Province, China. Electronic address: cxx@njau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20181014
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (Ochratoxins)
RN  - 0 (Protein Kinase Inhibitors)
RN  - 0 (Reactive Oxygen Species)
RN  - 1779SX6LUY (ochratoxin A)
RN  - 1EQV5MLY3D (Taurine)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
SB  - IM
MH  - AMP-Activated Protein Kinases/*metabolism
MH  - Animals
MH  - Autophagy/*drug effects
MH  - Cells, Cultured
MH  - Circovirus/*drug effects/growth & development
MH  - Dose-Response Relationship, Drug
MH  - Ochratoxins/*antagonists & inhibitors/pharmacology
MH  - Protein Kinase Inhibitors/pharmacology
MH  - Reactive Oxygen Species/*metabolism
MH  - Signal Transduction/drug effects
MH  - Structure-Activity Relationship
MH  - Swine
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Taurine/chemistry/*pharmacology
MH  - Virus Replication/*drug effects
OTO - NOTNLM
OT  - 5'AMP-activated protein kinase
OT  - Autophagy
OT  - Ochratoxin A
OT  - Porcine circovirus type 2
OT  - Taurine
EDAT- 2018/10/18 06:00
MHDA- 2018/12/27 06:00
CRDT- 2018/10/18 06:00
PHST- 2018/07/27 00:00 [received]
PHST- 2018/09/18 00:00 [revised]
PHST- 2018/10/13 00:00 [accepted]
PHST- 2018/10/18 06:00 [pubmed]
PHST- 2018/12/27 06:00 [medline]
PHST- 2018/10/18 06:00 [entrez]
AID - S0009-2797(18)30988-8 [pii]
AID - 10.1016/j.cbi.2018.10.005 [doi]
PST - ppublish
SO  - Chem Biol Interact. 2018 Dec 25;296:220-228. doi: 10.1016/j.cbi.2018.10.005. Epub 
      2018 Oct 14.