PMID- 30334408
OWN - NLM
STAT- MEDLINE
DCOM- 20190315
LR  - 20190315
IS  - 0393-974X (Print)
IS  - 0393-974X (Linking)
VI  - 32
IP  - 5
DP  - 2018 Sep-Oct
TI  - Detection of serum procalcitonin and hypersensitive C-reactive protein in 
      patients with pneumonia and sepsis.
PG  - 1165-1169
AB  - Sepsis, a systemic inflammatory response syndrome induced by infection, has high 
      rates of morbidity and mortality. Pneumonia is a major cause for sepsis; however, 
      pneumonia complicated by sepsis is a difficult clinical diagnosis. To assess the 
      clinical relevance of serum procalcitonin (PCT) and hypersensitive C-reactive 
      protein (hs-CRP) in early diagnosis of pneumonia complicated by sepsis, 220 
      patients with pneumonia who were admitted to hospital from July 2015 to July 2016 
      were enrolled in this study. The patients were divided into non-sepsis (N=82), 
      mild sepsis (N=97), severe sepsis (N=23), and septic shock (N=18) groups. The 
      patients were also divided into a survival group (N=186) and a death group (N=34) 
      according to their prognosis at 2 weeks. The PCT and hs-CRP levels and Acute 
      Physiology and Chronic Health Evaluation-II (APACHE-II) scores of the two groups 
      were evaluated. The PCT level and APACHE-II score showed a progressively 
      increasing tendency in the non-sepsis, mild sepsis, severe sepsis, and septic 
      shock group; the differences between all pairs of groups were significant (P less 
      than 0.05). The hs-CRP level was significantly lower in the non-sepsis group than 
      in the other groups (P less than 0.05), but differences among the other groups 
      were not significant (P>0.05). The areas under the receiver operating 
      characteristic curves of PCT and hs-CRP for diagnosis of pneumonia complicated by 
      mild and severe sepsis were 0.841 and 0.817, respectively. The optimal cut-off 
      points for pneumonia and sepsis were >/=0.5 ng/mL and >/=55 mg/L, respectively; the 
      sensitivity and specificity were 71.42% and 82.13%, and 75.04% and 53.61%, 
      respectively. The sensitivity and specificity of diagnosis based on PCT and 
      hs-CRP were 89.32% and 85.68%, respectively. PCT and hs-CRP are used to assess 
      the severity of pneumonia in combination with sepsis in new-borns, but PCT is 
      more strongly related to the severity of sepsis than is hs-CRP. Detection of PCT 
      in combination with hs-CRP facilitates the early diagnosis of pneumonia and 
      sepsis in new-borns, as well as monitoring of the treatment response and 
      prediction of the prognosis.
FAU - Liu, G B
AU  - Liu GB
AD  - Clinico-Medical Biochemistry Laboratory, Department of Biochemistry, Faculty of 
      Sciences, University of Agriculture, Faisalabad, Pakistan.
FAU - Cui, X Q
AU  - Cui XQ
AD  - Hemodialysis Room, Binzhou City Center Hospital, Bingzhou, China.
FAU - Wang, Z B
AU  - Wang ZB
AD  - Neurosurgery, Binzhou City Center Hospital, Bingzhou, China.
FAU - Wen, L
AU  - Wen L
AD  - Ophthalmology Department, Binzhou City Center Hospital, Bingzhou, China.
FAU - Duan, H L
AU  - Duan HL
AD  - Hemodialysis Room, Binzhou City Center Hospital, Bingzhou, China.
LA  - eng
PT  - Letter
PT  - Observational Study
PL  - Italy
TA  - J Biol Regul Homeost Agents
JT  - Journal of biological regulators and homeostatic agents
JID - 8809253
RN  - 0 (Biomarkers)
RN  - 0 (Procalcitonin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*analysis
MH  - Case-Control Studies
MH  - Early Diagnosis
MH  - Humans
MH  - Pneumonia/*blood/*complications/diagnosis
MH  - Procalcitonin/*blood
MH  - Prognosis
MH  - Sepsis/*blood/*complications/diagnosis/mortality
EDAT- 2018/10/20 06:00
MHDA- 2019/03/16 06:00
CRDT- 2018/10/19 06:00
PHST- 2018/10/19 06:00 [entrez]
PHST- 2018/10/20 06:00 [pubmed]
PHST- 2019/03/16 06:00 [medline]
AID - 12 [pii]
PST - ppublish
SO  - J Biol Regul Homeost Agents. 2018 Sep-Oct;32(5):1165-1169.