PMID- 30335064
OWN - NLM
STAT- MEDLINE
DCOM- 20190327
LR  - 20190327
IS  - 0004-1955 (Print)
IS  - 0004-1955 (Linking)
VI  - 80
IP  - 5
DP  - 2018
TI  - [Chronic diseases, precancer, and cancer of the lung, which are associated with 
      pathology of the club cells of respiratory and terminal bronchioles].
PG  - 63-68
LID - 10.17116/patol20188005163 [doi]
AB  - The review of the literature deals with the participation of Clara cells now 
      called club cells (CCs) of the epithelium in the respiratory and terminal 
      bronchioles in the pathogenesis and morphogenesis of chronic inflammatory 
      diseases, precancer, and cancer of the lung, which develop in the respiratory 
      segments. The review summarizes data on the histophysiology of CCs and their 
      participation in the pathogenesis and morphogenesis of chronic interstitial lung 
      diseases, pneumoconiosis, chronic obstructive diseases, adenomatosis, and 
      adenocarcinoma of the lung. In this area, there is a bronchioloalveolar junction 
      area (BAJA), one of the most important stem cell niches. CCs are located in the 
      BAJA; they are progenitor tissue stem cells and play an important role in the 
      regeneration of the epithelium of the respiratory bronchioles and alveoli. 
      Pathology of CCs in the BAJA leads to the maintenance of chronic inflammation, to 
      the destruction of the lung elastic frame, and to impaired epithelial 
      regeneration, interstitial fibrosis, and adenomatosis. In this case, 
      decompensated inflammation, pathological regeneration, and fibrosis develop, 
      which, along with the action of carcinogenic agents, can contribute to the 
      accumulation of mutations and epigenetic rearrangements in the CCs, which 
      subsequently results in atypical adenomatous hyperplasia and adenocarcinoma of 
      the lung.
FAU - Demura, S A
AU  - Demura SA
AD  - I.M. Sechenov First Moscow State Medical University, Ministry of Health of 
      Russia, Moscow, Russia.
FAU - Kogan, E A
AU  - Kogan EA
AD  - I.M. Sechenov First Moscow State Medical University, Ministry of Health of 
      Russia, Moscow, Russia.
FAU - Goryachkina, V L
AU  - Goryachkina VL
AD  - I.M. Sechenov First Moscow State Medical University, Ministry of Health of 
      Russia, Moscow, Russia.
LA  - rus
PT  - Journal Article
PT  - Review
TT  - Khronicheskie zabolevaniia, predrak i rak legkikh, assotsiirovannye s patologiei 
      bulavovidnykh kletok respiratornykh i terminal'nykh bronkhiol.
PL  - Russia (Federation)
TA  - Arkh Patol
JT  - Arkhiv patologii
JID - 0370604
SB  - IM
MH  - *Bronchioles/cytology
MH  - Chronic Disease
MH  - Epithelial Cells
MH  - Humans
MH  - *Lung Neoplasms/pathology
OTO - NOTNLM
OT  - and cancer of the lung
OT  - club (Clara) cells
OT  - pathogenesis and morphogenesis of chronic inflammatory diseases
OT  - precancer
EDAT- 2018/10/20 06:00
MHDA- 2019/03/28 06:00
CRDT- 2018/10/19 06:00
PHST- 2018/10/19 06:00 [entrez]
PHST- 2018/10/20 06:00 [pubmed]
PHST- 2019/03/28 06:00 [medline]
AID - 10.17116/patol20188005163 [doi]
PST - ppublish
SO  - Arkh Patol. 2018;80(5):63-68. doi: 10.17116/patol20188005163.