PMID- 30335505
OWN - NLM
STAT- MEDLINE
DCOM- 20200728
LR  - 20200728
IS  - 2047-4881 (Electronic)
IS  - 2047-4873 (Linking)
VI  - 26
IP  - 1
DP  - 2019 Jan
TI  - Long-term mortality is increased in patients with undetected prediabetes and 
      type-2 diabetes hospitalized for worsening heart failure and reduced ejection 
      fraction.
PG  - 72-82
LID - 10.1177/2047487318807767 [doi]
AB  - BACKGROUND: We assessed the prevalence of newly diagnosed prediabetes and type-2 
      diabetes mellitus (T2DM), and their impact on long-term mortality in patients 
      hospitalized for worsening heart failure with reduced ejection fraction (HFrEF). 
      METHODS: We included patients hospitalized with HFrEF and New York Heart 
      Association (NYHA) functional class II-III. Baseline two-hour oral glucose 
      tolerance test was used to classify patients as normoglycaemic or having newly 
      diagnosed prediabetes or T2DM. Outcomes included post-discharge all-cause and 
      cardiovascular mortality during the median follow-up of 2.1 years. RESULTS: At 
      baseline, out of 150 patients (mean-age 57 +/- 12 years; 88% male), prediabetes was 
      diagnosed in 65 (43%) patients, and T2DM in 29 (19%) patients. These patients 
      were older and more often with NYHA class III symptoms, but distribution of 
      comorbidities was similar to normoglycaemic patients. Taking normoglycaemic 
      patients as a reference, adjusted risk of all-cause mortality was significantly 
      increased both in patients with prediabetes (hazard ratio, 2.6; 95% confidence 
      interval (CI), 1.1-6.3; p = 0.040) and in patients with T2DM (hazard ratio, 5.3; 
      95% CI, 1.7-15.3; p = 0.023). Likewise, both prediabetes (hazard ratio, 2.9; 95% 
      CI, 1.1-7.9; p = 0.041) and T2DM (hazard ratio, 9.7; 95% CI 2.9-36.7; p = 0.018) 
      independently increased the risk of cardiovascular mortality compared with 
      normoglycaemic individuals. There was no interaction between either prediabetes 
      or T2DM and heart failure aetiology or gender on study outcomes (all interaction 
      p-values > 0.05). CONCLUSIONS: Newly diagnosed prediabetes and T2DM are highly 
      prevalent in patients hospitalized for worsening HFrEF and NYHA functional class 
      II-III. Importantly, they impose independently increased long-term risk of higher 
      all-cause and cardiovascular mortality.
FAU - Pavlovic, Andrija
AU  - Pavlovic A
AD  - 1 Department of Cardiology, Clinical Centre of Serbia, Belgrade, Serbia.
FAU - Polovina, Marija
AU  - Polovina M
AD  - 1 Department of Cardiology, Clinical Centre of Serbia, Belgrade, Serbia.
AD  - 2 University of Belgrade, Faculty of Medicine, Serbia.
FAU - Ristic, Arsen
AU  - Ristic A
AD  - 1 Department of Cardiology, Clinical Centre of Serbia, Belgrade, Serbia.
AD  - 2 University of Belgrade, Faculty of Medicine, Serbia.
FAU - Seferovic, Jelena P
AU  - Seferovic JP
AD  - 2 University of Belgrade, Faculty of Medicine, Serbia.
AD  - 3 Clinic of Endocrinology and Metabolic Disorders, Clinical Centre of Serbia, 
      Belgrade, Serbia.
FAU - Veljic, Ivana
AU  - Veljic I
AD  - 1 Department of Cardiology, Clinical Centre of Serbia, Belgrade, Serbia.
FAU - Simeunovic, Dejan
AU  - Simeunovic D
AD  - 1 Department of Cardiology, Clinical Centre of Serbia, Belgrade, Serbia.
AD  - 2 University of Belgrade, Faculty of Medicine, Serbia.
FAU - Milinkovic, Ivan
AU  - Milinkovic I
AD  - 1 Department of Cardiology, Clinical Centre of Serbia, Belgrade, Serbia.
FAU - Krljanac, Gordana
AU  - Krljanac G
AD  - 1 Department of Cardiology, Clinical Centre of Serbia, Belgrade, Serbia.
AD  - 2 University of Belgrade, Faculty of Medicine, Serbia.
FAU - Asanin, Milika
AU  - Asanin M
AD  - 1 Department of Cardiology, Clinical Centre of Serbia, Belgrade, Serbia.
AD  - 2 University of Belgrade, Faculty of Medicine, Serbia.
FAU - Ostric-Pavlovic, Irena
AU  - Ostric-Pavlovic I
AD  - 4 Department of Allergology and Clinical Immunology, Belgrade, Serbia.
FAU - Seferovic, Petar M
AU  - Seferovic PM
AD  - 2 University of Belgrade, Faculty of Medicine, Serbia.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20181018
PL  - England
TA  - Eur J Prev Cardiol
JT  - European journal of preventive cardiology
JID - 101564430
SB  - IM
CIN - Eur J Prev Cardiol. 2019 Jan;26(1):68-71. PMID: 30370791
MH  - Adult
MH  - Aged
MH  - Diabetes Mellitus, Type 2/diagnosis/*mortality
MH  - Disease Progression
MH  - Female
MH  - Heart Failure/diagnosis/*mortality/physiopathology/therapy
MH  - *Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/diagnosis/*mortality
MH  - Prevalence
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Serbia/epidemiology
MH  - *Stroke Volume
MH  - Time Factors
MH  - *Ventricular Function, Left
OTO - NOTNLM
OT  - Heart failure with reduced ejection fraction
OT  - all-cause mortality
OT  - cardiovascular mortality
OT  - diabetes
OT  - prediabetes
EDAT- 2018/10/20 06:00
MHDA- 2020/07/29 06:00
CRDT- 2018/10/19 06:00
PHST- 2018/10/20 06:00 [pubmed]
PHST- 2020/07/29 06:00 [medline]
PHST- 2018/10/19 06:00 [entrez]
AID - 10.1177/2047487318807767 [doi]
PST - ppublish
SO  - Eur J Prev Cardiol. 2019 Jan;26(1):72-82. doi: 10.1177/2047487318807767. Epub 
      2018 Oct 18.