PMID- 30335884
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 120
IP  - 2
DP  - 2019 Feb
TI  - Reelin regulates male mouse reproductive capacity via the sertoli cells.
PG  - 1174-1184
LID - 10.1002/jcb.26824 [doi]
AB  - Reelin plays important roles in brain development. Reeler mutant mice that lack 
      the protein reelin (RELN) suffer from cell type- and region-dependent changes in 
      their neocortical layers, and adult reeler mutant mice have dilated seminiferous 
      tubules. Meanwhile, the mechanism by which Reelin regulates the spermatogenic 
      cell development in mice and their reproductive abilities remains unclear. In the 
      present study, we used reeler mutant mice to investigate the effects of Reelin on 
      reproduction in mice. The results indicated variations in sex hormone expression 
      among the reeler mice, indicating that they produce few offspring and their 
      spermatogenic cells are irregularly developed. Moreover, glial cell line-derived 
      neurotrophic factor (GDNF)/GDNF family receptor alpha 1, Ras/extracellular 
      regulated protein kinases (ERK), and promyelocytic leukemia zinc finger 
      (PLZF)/chemokine (C-X-C motif) receptor 4 (CXCR4) serve as potential regulatory 
      pathways that respond to the changes in sertoli cells and the niche of male germ 
      cells. Our findings provided valuable insights into the role of reeler in the 
      reproductive abilities of male mice and development of their spermatogonia stem 
      cells.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Zhuang, Mengru
AU  - Zhuang M
AD  - College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & 
      Technology, Northwest A&F University, Yangling, Shaanxi, China.
FAU - Li, Bo
AU  - Li B
AD  - College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & 
      Technology, Northwest A&F University, Yangling, Shaanxi, China.
FAU - Huang, Yangxue
AU  - Huang Y
AD  - College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & 
      Technology, Northwest A&F University, Yangling, Shaanxi, China.
FAU - Lei, Qijing
AU  - Lei Q
AD  - College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & 
      Technology, Northwest A&F University, Yangling, Shaanxi, China.
FAU - Yan, Ruichuan
AU  - Yan R
AD  - College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & 
      Technology, Northwest A&F University, Yangling, Shaanxi, China.
FAU - Li, Na
AU  - Li N
AUID- ORCID: 0000-0002-4112-0944
AD  - College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & 
      Technology, Northwest A&F University, Yangling, Shaanxi, China.
FAU - Sidhu, Kuldip
AU  - Sidhu K
AD  - Centre for Healthy Brain Ageing, UNSW Medicine, Randwick, New South Wales, 
      Australia.
FAU - Cheng, Xiang
AU  - Cheng X
AD  - Department of Radiation Oncology, The Ohio State University Comprehensive Cancer 
      Center-Arthur G James Cancer Hospital, Columbus, Ohio.
FAU - Yan, Xinrong
AU  - Yan X
AD  - College of Life Science, Northwest University, Xi'an, Shaanxi, China.
FAU - Miao, Yiliang
AU  - Miao Y
AD  - College of Animal Sciences & Technology, College of Veterinary Medicine, Huazhong 
      Agricultural University, Wuhan, China.
FAU - Zhao, Shanting
AU  - Zhao S
AD  - College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & 
      Technology, Northwest A&F University, Yangling, Shaanxi, China.
FAU - Hua, Jinlian
AU  - Hua J
AD  - College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & 
      Technology, Northwest A&F University, Yangling, Shaanxi, China.
LA  - eng
GR  - 31572399/Program of National Natural Science Foundation of China/
GR  - 31272518/Program of National Natural Science Foundation of China/
GR  - 2016YFA0100203/National Key Research and Development Program of China, Stem Cell 
      and Translational Research/
PT  - Journal Article
DEP - 20181018
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
SB  - IM
OTO - NOTNLM
OT  - Reelin
OT  - androgen
OT  - follicle-stimulating hormone (FSH)
OT  - sertoli cells
OT  - spermatogenic stem cells (SSCs)
OT  - testis
EDAT- 2018/10/20 06:00
MHDA- 2018/10/20 06:01
CRDT- 2018/10/19 06:00
PHST- 2017/06/12 00:00 [received]
PHST- 2018/02/28 00:00 [accepted]
PHST- 2018/10/20 06:00 [pubmed]
PHST- 2018/10/20 06:01 [medline]
PHST- 2018/10/19 06:00 [entrez]
AID - 10.1002/jcb.26824 [doi]
PST - ppublish
SO  - J Cell Biochem. 2019 Feb;120(2):1174-1184. doi: 10.1002/jcb.26824. Epub 2018 Oct 
      18.