PMID- 3033752
OWN - NLM
STAT- MEDLINE
DCOM- 19870602
LR  - 20190828
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 17
IP  - 2
DP  - 1987 Feb
TI  - Effect of kassinin, neurokinin A and neurokinin B on drinking behaviour in the 
      pigeon.
PG  - 85-97
AB  - Intracerebroventricular (i.c.v.) injection of kassinin produced a prompt and 
      copious drinking response at doses of 10-1000 ng/pigeon, in the absence of other 
      behavioural alterations or of changes in core temperature. Neurokinin A and B 
      evoked drinking, but they were respectively 10 and 100 times less potent than 
      kassinin. Intraperitoneal injection of kassinin elicited drinking, but at doses 
      about 1000 X larger than the i.c.v. ones. The angiotensin antagonist [Sar1, 
      Leu8]angiotensin II did not reduce drinking induced by i.c.v. kassinin, 
      suggesting that its effect is not due to interaction with the central 
      renin-angiotensin system. Moreover, the effect is apparently independent of the 
      mechanisms controlling hypovolaemic and hyperosmotic thirst since exact 
      additivity was found in the dipsogenic response when i.c.v. kassinin was 
      administered in the presence of a hypovolaemic (subcutaneous (s.c.), polyethylene 
      glycol) or hyperosmotic (s.c. hypertonic NaCl) dipsogenic stimulus. The present 
      findings show that kassinin, neurokinin A and B share with the tachykinins 
      already tested (eledoisin, physalaemin, substance P) a common dipsogenic action 
      in pigeons. However, marked differences exist in their dipsogenic potency. This 
      order of potency, eledoisin = kassinin = physalaemin greater than neurokinin A = 
      substance P greater than neurokinin B, is not consistent with the tachykinin 
      receptor subtypes so far proposed.
FAU - Massi, M
AU  - Massi M
FAU - Perfumi, M
AU  - Perfumi M
FAU - Polidori, C
AU  - Polidori C
FAU - de Caro, G
AU  - de Caro G
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Neuropeptides)
RN  - 0 (Oligopeptides)
RN  - 11128-99-7 (Angiotensin II)
RN  - 53814-27-0 (sarleucin)
RN  - 63968-82-1 (Kassinin)
RN  - 86933-74-6 (Neurokinin A)
RN  - 86933-75-7 (Neurokinin B)
SB  - IM
MH  - Angiotensin II/analogs & derivatives/pharmacology
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Columbidae
MH  - Drinking Behavior/*drug effects
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Kassinin
MH  - Male
MH  - Neurokinin A
MH  - Neurokinin B
MH  - Neuropeptides/*pharmacology
MH  - Oligopeptides/*pharmacology
EDAT- 1987/02/01 00:00
MHDA- 1987/02/01 00:01
CRDT- 1987/02/01 00:00
PHST- 1987/02/01 00:00 [pubmed]
PHST- 1987/02/01 00:01 [medline]
PHST- 1987/02/01 00:00 [entrez]
AID - 0167-0115(87)90015-2 [pii]
AID - 10.1016/0167-0115(87)90015-2 [doi]
PST - ppublish
SO  - Regul Pept. 1987 Feb;17(2):85-97. doi: 10.1016/0167-0115(87)90015-2.