PMID- 30338233
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2231-4040 (Print)
IS  - 0976-2094 (Electronic)
IS  - 0976-2094 (Linking)
VI  - 9
IP  - 3
DP  - 2018 Jul-Sep
TI  - Differential effect of metformin and/or glyburide on apelin serum levels in 
      patients with type 2 diabetes mellitus: Concepts and clinical practice.
PG  - 80-86
LID - 10.4103/japtr.JAPTR_273_18 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with abundant 
      adipocytokine changes which may play an important role in the progression of 
      insulin resistance and micro- and macro-vascular complications. Therefore, the 
      objective of this study was to assess the differential effect of metformin alone 
      or in combination with glyburide on apelin serum levels in patients with T2DM. In 
      this case-control study, fifty patients with T2DM in the age range of 45-65 years 
      and twenty-five healthy controls matched for age and body weight were recruited 
      from single endocrinology center, subdivided according to the diabetic 
      pharmacotherapy into: Group I: healthy controls (n = 25), Group II: T2DM patients 
      on metformin (n = 15), Group III: T2DM patients on glyburide (n = 17), and Group 
      IV: T2DM patients on metformin plus glyburide (n = 28). Biochemical and 
      anthropometric variables in relation to apelin serum levels were estimated. 
      Apelin serum levels were low in normal healthy controls compared to T2DM patients 
      (P < 0.01). The differential effect of diabetic pharmacotherapy on apelin serum 
      level was statistically significant (P < 0.01) compared to the controls, but 
      insignificant when compared among used drugs (P > 0.05). Apelin level was high in 
      T2DM compared to the controls; both metformin and glyburide might play a role in 
      this elevation.
FAU - Al-Kuraishy, Hayder M
AU  - Al-Kuraishy HM
AD  - Department of Pharmacology, Toxicology and Medicine, College of Medicine, 
      Almustansiriya University, Baghdad, Iraq.
FAU - Al-Gareeb, Ali I
AU  - Al-Gareeb AI
AD  - Department of Pharmacology, Toxicology and Medicine, College of Medicine, 
      Almustansiriya University, Baghdad, Iraq.
FAU - Waheed, Huda J
AU  - Waheed HJ
AD  - Department of Pharmacology, Toxicology and Medicine, College of Medicine, 
      Almustansiriya University, Baghdad, Iraq.
FAU - Al-Maiahy, Thabat J
AU  - Al-Maiahy TJ
AD  - Department of Pharmacology, Toxicology and Medicine, College of Medicine, 
      Almustansiriya University, Baghdad, Iraq.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Adv Pharm Technol Res
JT  - Journal of advanced pharmaceutical technology & research
JID - 101537797
PMC - PMC6174705
OTO - NOTNLM
OT  - Apelin
OT  - glyburide
OT  - metformin
OT  - type 2 diabetes mellitus
COIS- There are no conflicts of interest.
EDAT- 2018/10/20 06:00
MHDA- 2018/10/20 06:01
PMCR- 2018/07/01
CRDT- 2018/10/20 06:00
PHST- 2018/10/20 06:00 [entrez]
PHST- 2018/10/20 06:00 [pubmed]
PHST- 2018/10/20 06:01 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
AID - JAPTR-9-80 [pii]
AID - 10.4103/japtr.JAPTR_273_18 [doi]
PST - ppublish
SO  - J Adv Pharm Technol Res. 2018 Jul-Sep;9(3):80-86. doi: 
      10.4103/japtr.JAPTR_273_18.