PMID- 30338614 OWN - NLM STAT- MEDLINE DCOM- 20190808 LR - 20220408 IS - 1479-8301 (Electronic) IS - 1346-3500 (Linking) VI - 19 IP - 2 DP - 2019 Mar TI - Association between changes in the use of psychotropic drugs and behavioural and psychological symptoms of dementia over 1 year among long-term care facility residents. PG - 126-134 LID - 10.1111/psyg.12374 [doi] AB - AIM: Pharmacological treatments are often used in treating the behavioural and psychological symptoms of dementia (BPSD) in nursing homes, despite the fact that non-pharmacological treatments are recommended as a first-line treatment and can provide a suitable alternative. Because the course of BPSD is known to fluctuate depending on individual symptoms over time, the frequencies of drug use and BPSD, as well as their association, should be observed over a longer period. We investigated the association between the changes in psychotropic drug (PD) use and BPSD, focusing on the number of symptoms, severity, and care burden over 1 year among long-term care facility residents. METHODS: A 1-year follow-up study was conducted among older residents with dementia or similar symptoms (n = 312 at baseline; n = 237 at follow-up) by using a care staff questionnaire in 10 long-term care facilities in Hokkaido, Japan. Medication use was determined based on prescription information. The brief questionnaire form of the Neuropsychiatric Inventory was used to assess BPSD. RESULTS: Among residents followed up for 1 year, new users of PD-particularly anxiolytics and hypnotics-had a significantly increased number and severity of BPSD, compared with non-PD users. Continuing PDs was also related to increased severity over the year. Among residents with any persistent BPSD for 1 year, new use of PDs-particularly anxiolytics and hypnotics-was significantly associated with an increased care burden of BPSD, compared with the non-use of PDs. The discontinuation of PDs was significantly associated with a decreased care burden, compared with the non-use of PDs. CONCLUSIONS: Our study suggests that PDs, particularly anxiolytics and hypnotics, may be prescribed carefully in response to exacerbation of BPSD in terms of the number of symptoms, severity, and care burden in long-term care facilities. Continuous monitoring of PDs use and BPSD is important to effectively address BPSD. CI - (c) 2018 Japanese Psychogeriatric Society. FAU - Ozaki, Takashi AU - Ozaki T AD - School of Medicine, Hokkaido University, Sapporo, Japan. FAU - Katsumata, Yuriko AU - Katsumata Y AD - Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, Kentucky, USA. FAU - Arai, Asuna AU - Arai A AUID- ORCID: 0000-0001-5091-0035 AD - Department of Health Care Policy, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. LA - eng GR - 26860431 and 17K09187/Japan Society for the Promotion of Science KAKENHI/ PT - Journal Article DEP - 20181018 PL - England TA - Psychogeriatrics JT - Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society JID - 101230058 RN - 0 (Psychotropic Drugs) MH - Aged, 80 and over MH - Cohort Studies MH - Dementia/*drug therapy/*psychology MH - Female MH - Follow-Up Studies MH - *Homes for the Aged MH - Humans MH - Japan MH - Long-Term Care MH - Longitudinal Studies MH - Male MH - *Nursing Homes MH - Prospective Studies MH - Psychiatric Status Rating Scales MH - Psychotropic Drugs/*therapeutic use MH - Severity of Illness Index OTO - NOTNLM OT - long-term care OT - longitudinal study OT - major neurocognitive disorder OT - neuropsychiatric symptoms OT - residential facilities EDAT- 2018/10/20 06:00 MHDA- 2019/08/09 06:00 CRDT- 2018/10/20 06:00 PHST- 2018/03/22 00:00 [received] PHST- 2018/07/11 00:00 [revised] PHST- 2018/08/13 00:00 [accepted] PHST- 2018/10/20 06:00 [pubmed] PHST- 2019/08/09 06:00 [medline] PHST- 2018/10/20 06:00 [entrez] AID - 10.1111/psyg.12374 [doi] PST - ppublish SO - Psychogeriatrics. 2019 Mar;19(2):126-134. doi: 10.1111/psyg.12374. Epub 2018 Oct 18.