PMID- 30338651
OWN - NLM
STAT- MEDLINE
DCOM- 20190409
LR  - 20191210
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 21
IP  - 10
DP  - 2018 Oct
TI  - Target setting for lower limb joint surgery using the Timed Up and Go test in 
      patients with rheumatoid arthritis: A prospective cohort study.
PG  - 1801-1808
LID - 10.1111/1756-185X.13394 [doi]
AB  - OBJECTIVE: This prospective observational cohort study aimed to set targets for 
      lower limb joint surgery based on the Timed Up and Go test (TUG), an objective 
      functional outcome measure, in patients with established rheumatoid arthritis 
      (RA). METHODS: We validated TUG as an outcome measure of lower limb joint surgery 
      and compared it with changes in patient-reported outcomes, including the Health 
      Assessment Questionnaire Disability Index (HAQ-DI) and European Quality of life 
      scale with five dimensions (EQ-5D). Changes in these outcomes were compared by 
      performed surgery and by achievement of the minimal clinically important 
      difference (MCID) for EQ-5D using univariate analysis of variance. Associations 
      between TUG and HAQ remission (HAQ-DI </=0.5) were determined using logistic 
      regression analysis. Cut-off values of TUG at baseline and 6 months after surgery 
      for HAQ remission were determined using receiver operating characteristic curves. 
      RESULTS: A total of 126 patients were analyzed. Mean age, HAQ-DI, and TUG were 
      65.4 years, 1.036, and 12.8 seconds, respectively. After surgery, patients showed 
      improvements in TUG as well as HAQ-DI. TUG at 6 months after surgery was 
      significantly associated with HAQ remission (adjusted OR: 0.78; 95% CI: 
      0.65-0.93). TUG cut-off values at baseline and 6 months after surgery for 
      achieving HAQ remission were 12.1 and 8.8 seconds, respectively. Significant 
      improvements in TUG (∆TUG, 3.7 seconds) were associated with achievement of the 
      MCID for EQ-5D (>/=0.05) at 6 months after surgery. CONCLUSION: Timed Up and Go 
      test is a useful tool for assessing the outcome of lower limb joint surgery in RA 
      patients. We propose that TUG </=9 seconds could be an objective target for 
      achieving good physical function after lower limb joint surgery.
CI  - (c) 2018 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons 
      Australia, Ltd.
FAU - Kojima, Toshihisa
AU  - Kojima T
AUID- ORCID: 0000-0001-8497-0212
AD  - Department of Orthopaedic Surgery, Nagoya University Hospital, Nagoya, Japan.
FAU - Ishikawa, Hajime
AU  - Ishikawa H
AD  - Department of Rheumatology, Niigata Rheumatic Center, Niigata, Japan.
FAU - Tanaka, Sakae
AU  - Tanaka S
AD  - Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 
      Tokyo, Japan.
FAU - Haga, Nobuhiko
AU  - Haga N
AD  - Department of Rehabilitation Medicine, The University of Tokyo Hospital, Tokyo, 
      Japan.
FAU - Nishida, Keiichiro
AU  - Nishida K
AD  - Department of Orthopaedic Surgery, Dentistry and Pharmaceutical Sciences, Okayama 
      University Graduate School of Medicine, Okayama, Japan.
FAU - Yukioka, Masao
AU  - Yukioka M
AD  - Department of Orthopaedic Surgery, Yukioka Hospital, Osaka, Japan.
FAU - Hashimoto, Jun
AU  - Hashimoto J
AD  - Department of Rheumatology, National Hospital Organisation Osaka Minami Medical 
      Center, Kawachinagano, Japan.
FAU - Miyahara, Hisaaki
AU  - Miyahara H
AD  - Department of Orthopaedic Surgery, National Hospital Organisation Kyushu Medical 
      Center, Fukuoka, Japan.
FAU - Niki, Yasuo
AU  - Niki Y
AD  - Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Kimura, Tomoatsu
AU  - Kimura T
AD  - Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 
      Toyama, Japan.
FAU - Oda, Hiromi
AU  - Oda H
AD  - Department of Orthopaedic Surgery, Saitama Medical University, Morohongo 
      Moroyama, Japan.
FAU - Asai, Shuji
AU  - Asai S
AUID- ORCID: 0000-0002-4030-8793
AD  - Department of Orthopaedic Surgery, Nagoya University Hospital, Nagoya, Japan.
FAU - Funahashi, Koji
AU  - Funahashi K
AD  - Department of Orthopaedic Surgery, Kariya-Toyota General Hospital, Kariya, Japan.
FAU - Kojima, Masayo
AU  - Kojima M
AD  - Department of Medical Education, Nagoya City University Graduate School of 
      Medical Sciences, Nagoya, Japan.
FAU - Ishiguro, Naoki
AU  - Ishiguro N
AD  - Department of Orthopaedic Surgery, Nagoya University Hospital, Nagoya, Japan.
LA  - eng
GR  - N/A/Nagoya University Hospital Funding for Clinical Research/
GR  - H2424YN002-00/Japanese Ministry of Health, Labour and Welfare/
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Validation Study
DEP - 20181018
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
SB  - IM
MH  - Aged
MH  - Arthritis, Rheumatoid/*diagnosis/physiopathology/surgery
MH  - Biomechanical Phenomena
MH  - *Disability Evaluation
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Japan
MH  - Joints/*physiopathology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Patient Reported Outcome Measures
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Quality of Life
MH  - Range of Motion, Articular
MH  - Recovery of Function
MH  - Reproducibility of Results
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Timed Up and Go test
OT  - joint surgery
OT  - outcome measure
OT  - physical function
OT  - rheumatoid arthritis
EDAT- 2018/10/20 06:00
MHDA- 2019/04/10 06:00
CRDT- 2018/10/20 06:00
PHST- 2018/04/20 00:00 [received]
PHST- 2018/08/11 00:00 [revised]
PHST- 2018/08/26 00:00 [accepted]
PHST- 2018/10/20 06:00 [pubmed]
PHST- 2019/04/10 06:00 [medline]
PHST- 2018/10/20 06:00 [entrez]
AID - 10.1111/1756-185X.13394 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2018 Oct;21(10):1801-1808. doi: 10.1111/1756-185X.13394. Epub 
      2018 Oct 18.