PMID- 30341412
OWN - NLM
STAT- MEDLINE
DCOM- 20200402
LR  - 20220416
IS  - 1530-0447 (Electronic)
IS  - 0031-3998 (Linking)
VI  - 85
IP  - 2
DP  - 2019 Jan
TI  - Changes in neuroplasticity following early-life social adversities: the possible 
      role of brain-derived neurotrophic factor.
PG  - 225-233
LID - 10.1038/s41390-018-0205-7 [doi]
AB  - Social adversities experienced in childhood can have a profound impact on the 
      developing brain, leading to the emergence of psychopathologies in adulthood. 
      Despite the burden this places on both the individual and society, the 
      neurobiological aspects mediating this transition remain unclear. Recent advances 
      in preclinical and clinical research have begun examining neuroplasticity-the 
      nervous system's ability to form adaptive changes in response to new 
      experience-in the context of early-life vulnerability to social adversities and 
      plasticity-related alterations following such traumatic events. A key mediator of 
      plasticity-related molecular processes is the brain-derived neurotrophic factor 
      (BDNF), which has also been implicated in various psychiatric disorders related 
      to childhood social adversities. Preclinical and clinical data suggest early-life 
      social adversities (ELSA) might be associated with accelerated maturation of 
      social network circuitry, a possible ontogenic adaptation to the adverse 
      environment. Neural plasticity decreases by adulthood, lessening the efficacy of 
      treatment in ELSA-related psychiatric disorders. However, literature data suggest 
      that by increasing BDNF/TrkB signalling through antidepressant treatment a 
      juvenile-like plasticity state can be induced, which allows for reorganization of 
      the social circuitry when guided by psychotherapy and surrounded by a safe and 
      positive environment.
FAU - Miskolczi, Christina
AU  - Miskolczi C
AD  - Department of Behavioural Neurobiology, Institute of Experimental Medicine of the 
      Hungarian Academy of Sciences, Budapest, Hungary.
FAU - Halasz, Jozsef
AU  - Halasz J
AD  - Vadaskert Child and Adolescent Psychiatry Hospital, Budapest, Hungary.
FAU - Mikics, Eva
AU  - Mikics E
AD  - Department of Behavioural Neurobiology, Institute of Experimental Medicine of the 
      Hungarian Academy of Sciences, Budapest, Hungary. mikics.eva@koki.mta.hu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20181015
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism/*physiology
MH  - Child, Preschool
MH  - Humans
MH  - Infant
MH  - Life Change Events
MH  - Neuronal Plasticity
MH  - Polymorphism, Single Nucleotide
MH  - Signal Transduction
MH  - *Social Behavior
EDAT- 2018/10/21 06:00
MHDA- 2020/04/03 06:00
CRDT- 2018/10/21 06:00
PHST- 2018/08/01 00:00 [received]
PHST- 2018/10/04 00:00 [accepted]
PHST- 2018/10/01 00:00 [revised]
PHST- 2018/10/21 06:00 [pubmed]
PHST- 2020/04/03 06:00 [medline]
PHST- 2018/10/21 06:00 [entrez]
AID - 10.1038/s41390-018-0205-7 [pii]
AID - 10.1038/s41390-018-0205-7 [doi]
PST - ppublish
SO  - Pediatr Res. 2019 Jan;85(2):225-233. doi: 10.1038/s41390-018-0205-7. Epub 2018 
      Oct 15.