PMID- 30341586
OWN - NLM
STAT- MEDLINE
DCOM- 20200521
LR  - 20200521
IS  - 1522-1709 (Electronic)
IS  - 1520-9512 (Linking)
VI  - 23
IP  - 2
DP  - 2019 Jun
TI  - Do you have restless leg syndrome? I understood from your eyes.
PG  - 551-557
LID - 10.1007/s11325-018-1740-5 [doi]
AB  - PURPOSE: According to many studies in the literature, there is a strong 
      association between restless leg syndrome and dopaminergic dysfunction. Dopamine 
      is also the major catecholamine in the retina and is also a possible transmitter 
      of the amacrine and interplexiform cells. The aim of this study is to investigate 
      the possible association between RLS and retinal thickness. METHODS: In this 
      study, we included 33 patients who were diagnosed with idiopathic RLS according 
      to the "International RLS Study Group" criteria and 31 healthy subjects. All the 
      patients and controls underwent routine ophthalmologic examination and had 
      spectral-domain optical coherence tomography (OCT) performed. We compared the 
      retinal thickness of the patients and control subjects. RESULTS: In the RLS 
      group, foveal thickness was thinner then controls. Also, only inferior, superior, 
      and temporal quadrant retina nerve fiber layer (RNFL) thickness were 
      significantly thinner in the RLS group. The parafoveal ganglion cell complex 
      (GCC) in the superior temporal, inferior temporal, inferior nasal quadrant, and 
      perifoveal superior nasal thickness was also significantly thinner in the patient 
      group. Pearson correlation analyses showed that there were statistically 
      significant negative correlations between disease duration and macular GCC and 
      RNFL thickness. Negative correlations were also detected between parafoveal 
      superior, temporal, inferior and nasal macular thickness, parafoveal superior 
      nasal, inferior temporal GCC thickness, and perifoveal superior nasal GCC 
      thickness and disease duration. CONCLUSION: According to our results; most 
      retinal layers are thinner in RLS patients, so it can be considered that OCT has 
      a predictive value for progression of RLS.
FAU - Kose Ozlece, Hatice
AU  - Kose Ozlece H
AD  - Department of Neurology, Acibadem Private Hospital, Kayseri, Turkey.
FAU - Solmaz, Volkan
AU  - Solmaz V
AD  - Department of Neurology, Private Konak Hospital, Sakarya, Turkey. 
      solmaz.volkan85@gmail.com.
FAU - Ozal, Sadik Altan
AU  - Ozal SA
AD  - Department of Eye Disease, Trakya University Medical Faculty, Edirne, Turkey.
FAU - Celik, Yahya
AU  - Celik Y
AD  - Department of Neurology, Adatip Private Hospital, Sakarya, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20181019
PL  - Germany
TA  - Sleep Breath
JT  - Sleep & breathing = Schlaf & Atmung
JID - 9804161
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
CIN - Sleep Breath. 2019 Sep;23(3):907-908. PMID: 30887228
CIN - Sleep Breath. 2019 Sep;23(3):909. PMID: 31302836
MH  - Adult
MH  - Aged
MH  - Correlation of Data
MH  - Disease Progression
MH  - Dopamine/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/physiology
MH  - Reference Values
MH  - Restless Legs Syndrome/classification/*diagnosis/*physiopathology
MH  - Retina/*physiopathology
MH  - Retinal Ganglion Cells/physiology
MH  - Tomography, Optical Coherence
OTO - NOTNLM
OT  - OCT
OT  - Restless leg syndrome
OT  - Retinal thickness
EDAT- 2018/10/21 06:00
MHDA- 2020/05/22 06:00
CRDT- 2018/10/21 06:00
PHST- 2018/04/08 00:00 [received]
PHST- 2018/10/08 00:00 [accepted]
PHST- 2018/09/20 00:00 [revised]
PHST- 2018/10/21 06:00 [pubmed]
PHST- 2020/05/22 06:00 [medline]
PHST- 2018/10/21 06:00 [entrez]
AID - 10.1007/s11325-018-1740-5 [pii]
AID - 10.1007/s11325-018-1740-5 [doi]
PST - ppublish
SO  - Sleep Breath. 2019 Jun;23(2):551-557. doi: 10.1007/s11325-018-1740-5. Epub 2018 
      Oct 19.