PMID- 30342830
OWN - NLM
STAT- MEDLINE
DCOM- 20191112
LR  - 20191112
IS  - 1768-3181 (Electronic)
IS  - 0003-3928 (Linking)
VI  - 68
IP  - 2
DP  - 2019 Apr
TI  - [ST elevation myocardial infarction in young adults: Is there an interest for 
      thrombophilia screening?].
PG  - 98-106
LID - S0003-3928(18)30161-6 [pii]
LID - 10.1016/j.ancard.2018.09.012 [doi]
AB  - BACKGROUND: Coronary lesions characteristics as well as patient thrombogenicity 
      can explain coronary events manifestation. In young patient, local conditions are 
      usually less important and thrombogenicity could play a significant role. 
      Assessing thrombophilia could be justified in young patients and may induce an 
      adapted therapeutic management. PURPOSE: We aimed to assess the prevalence of 
      thrombophilia and therapeutic modification in young adults aged</=55 years admitted 
      in our department for ST elevation myocardial infarction (STEMI). METHODS: From 
      January 2013 to January 2017, data on all patients aged</=55 years with STEMI 
      admitted in emergency were retrospectively retrieved from our database. 
      Thrombophilia investigation was made regarding clinical (with or without 
      cardiovascular risk factors [CVRF]), biological and/or angiographic evaluation. 
      RESULTS: A total of 133 patients aged</=55 years with STEMI were included. Cardiac 
      arrest occurred in 15 patients (11%). One or less CVRF were found in 47 patients 
      (35%). Smoking was reported in 93 patients (70%) and drug addiction (cannabis, 
      cocaine) in 19 patients (14%). A subset of 51 patients (38%) were screened for 
      thrombophilia. Patients with thrombophilia assessment were younger, less active 
      smokers and presented less CVRF than patients without investigation (P<0.001). 
      Single vessel diseased was found in 88 patients (66%). No differences regarding 
      coronary procedural characteristic were found between the two groups. The most 
      frequently encountered aetiology, found in 122 patients (92%), was de novo 
      intra-arterial thrombosis related to atherosclerosis. In patients with 
      thrombophilia assessment (n=51), one or more abnormal biological results was 
      found in 22 patients (43%) and a therapeutic adjustment was made in 6 patients 
      (12%). CONCLUSION: Thrombophilia screening in young STEMI adults showed an 
      abnormality in 43% of cases. Antithrombotic treatment can be modified after its 
      demonstration.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Spagnoli, V
AU  - Spagnoli V
AD  - Service de cardiologie, hopital Lariboisiere, 2, rue Ambroise Pare, 75010 Paris, 
      France. Electronic address: vincent.spagnoli@outlook.fr.
FAU - Diefenbronn, M
AU  - Diefenbronn M
AD  - Service de cardiologie, hopital Lariboisiere, 2, rue Ambroise Pare, 75010 Paris, 
      France.
FAU - Merat, B
AU  - Merat B
AD  - Service de cardiologie, hopital Lariboisiere, 2, rue Ambroise Pare, 75010 Paris, 
      France.
FAU - Logeart, D
AU  - Logeart D
AD  - Service de cardiologie, hopital Lariboisiere, 2, rue Ambroise Pare, 75010 Paris, 
      France.
FAU - Sideris, G
AU  - Sideris G
AD  - Service de cardiologie, hopital Lariboisiere, 2, rue Ambroise Pare, 75010 Paris, 
      France.
FAU - Henry, P
AU  - Henry P
AD  - Service de cardiologie, hopital Lariboisiere, 2, rue Ambroise Pare, 75010 Paris, 
      France.
FAU - Manzo-Silberman, S
AU  - Manzo-Silberman S
AD  - Service de cardiologie, hopital Lariboisiere, 2, rue Ambroise Pare, 75010 Paris, 
      France.
FAU - Drouet, L
AU  - Drouet L
AD  - Service d'hemostase, hopital Lariboisiere, 2, rue Ambroise Pare, 75010 Paris, 
      France.
FAU - Dillinger, J G
AU  - Dillinger JG
AD  - Service de cardiologie, hopital Lariboisiere, 2, rue Ambroise Pare, 75010 Paris, 
      France.
LA  - fre
PT  - Journal Article
TT  - Syndrome coronarien aigu avec sus-decalage du segment ST chez les jeunes 
      adultes : le bilan de thrombophilie a-t-il un interet ?
DEP - 20181017
PL  - France
TA  - Ann Cardiol Angeiol (Paris)
JT  - Annales de cardiologie et d'angeiologie
JID - 0142167
RN  - 0 (Fibrinolytic Agents)
SB  - IM
MH  - Acute Coronary Syndrome/complications
MH  - Adult
MH  - Age Factors
MH  - Atherosclerosis/complications
MH  - Emergencies
MH  - Female
MH  - Fibrinolytic Agents/*therapeutic use
MH  - Heart Arrest/etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - ST Elevation Myocardial Infarction/*complications/pathology
MH  - Smoking/epidemiology
MH  - Substance-Related Disorders/epidemiology
MH  - Thrombophilia/*diagnosis/drug therapy/etiology
MH  - Thrombosis/diagnosis/etiology/*prevention & control
OTO - NOTNLM
OT  - Adulte jeune
OT  - Homocysteinemia
OT  - Homocysteine
OT  - JAK2
OT  - SCA ST+
OT  - STEMI
OT  - Thrombophilia
OT  - Thrombophilie
OT  - Young adults
EDAT- 2018/10/22 06:00
MHDA- 2019/11/13 06:00
CRDT- 2018/10/22 06:00
PHST- 2018/09/14 00:00 [received]
PHST- 2018/09/21 00:00 [accepted]
PHST- 2018/10/22 06:00 [pubmed]
PHST- 2019/11/13 06:00 [medline]
PHST- 2018/10/22 06:00 [entrez]
AID - S0003-3928(18)30161-6 [pii]
AID - 10.1016/j.ancard.2018.09.012 [doi]
PST - ppublish
SO  - Ann Cardiol Angeiol (Paris). 2019 Apr;68(2):98-106. doi: 
      10.1016/j.ancard.2018.09.012. Epub 2018 Oct 17.