PMID- 30343595 OWN - NLM STAT- MEDLINE DCOM- 20190308 LR - 20190718 IS - 1745-2422 (Electronic) IS - 1743-4440 (Linking) VI - 15 IP - 11 DP - 2018 Nov TI - Latest STEMI treatment: a focus on current and upcoming devices. PG - 807-817 LID - 10.1080/17434440.2018.1538778 [doi] AB - INTRODUCTION: Ischemic heart disease is the most common cause of mortality worldwide. In ST elevation myocardial infarction (STEMI) patients, optimization of primary percutaneous coronary intervention (pPCI) is crucial to improve myocardial savage and prevent reperfusion injury. In STEMI patients complicated with cardiogenic shock (CS), percutaneous mechanical circulatory support devices (MCS) have emerged as a therapeutic option in the management of this challenging condition and their use is rapidly increasing. AREAS COVERED: In this review we discuss how pPCI can be optimized with respect to thrombectomy use, stent selection and revascularization strategy, in order to reduce myocardial damage and to improve clinical outcomes. Moreover, we review the recently-published data for and against the use of commercially available MCS in STEMI patients complicated by CS (intra-aortic balloon pump counterpulsation (IABP), Impella system, TandemHeart, and venous-arterial extracorporeal membrane oxygenation (VA-ECMO)). EXPERT COMMENTARY: In pPCI, second-generation drug-eluting stent implantation and complete revascularization are always recommended. Thrombectomy does not have any role in improving mortality. In patients with CS, current MCS have shown no improvement in mortality. FAU - Moscarella, Elisabetta AU - Moscarella E AD - a Hospital Clinic, Cardiovascular Clinic Institute , Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS) , Barcelona , Spain. FAU - Brugaletta, Salvatore AU - Brugaletta S AD - a Hospital Clinic, Cardiovascular Clinic Institute , Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS) , Barcelona , Spain. FAU - Sabate, Manel AU - Sabate M AD - a Hospital Clinic, Cardiovascular Clinic Institute , Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS) , Barcelona , Spain. LA - eng PT - Journal Article PT - Review DEP - 20181030 PL - England TA - Expert Rev Med Devices JT - Expert review of medical devices JID - 101230445 SB - IM MH - Animals MH - Heart-Assist Devices MH - Humans MH - Percutaneous Coronary Intervention/*instrumentation MH - ST Elevation Myocardial Infarction/complications/*therapy MH - Shock, Cardiogenic/complications MH - Stents MH - Thrombosis/therapy OTO - NOTNLM OT - Bare metal stent OT - Impella OT - ST elevation myocardial infarction OT - Tandemheart OT - drug eluting stent OT - extracorporeal membrane oxygenation OT - intra aortic balloon pump OT - percutaneous coronary intervention OT - thrombus aspiration OT - venous-arterial extracorporeal membrane oxygenation EDAT- 2018/10/23 06:00 MHDA- 2019/03/09 06:00 CRDT- 2018/10/23 06:00 PHST- 2018/10/23 06:00 [pubmed] PHST- 2019/03/09 06:00 [medline] PHST- 2018/10/23 06:00 [entrez] AID - 10.1080/17434440.2018.1538778 [doi] PST - ppublish SO - Expert Rev Med Devices. 2018 Nov;15(11):807-817. doi: 10.1080/17434440.2018.1538778. Epub 2018 Oct 30.