PMID- 30344677
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 16
IP  - 5
DP  - 2018 Nov
TI  - Immunomodulatory effect of Bifidobacterium breve on experimental allergic 
      rhinitis in BALB/c mice.
PG  - 3996-4004
LID - 10.3892/etm.2018.6704 [doi]
AB  - Bifidobacterium breve (B. breve) may have a beneficial effect on allergic 
      rhinitis (AR). The aim of the present study was to investigate whether microbial 
      induction of regulatory T cells (Tregs) and adjustment of Th1 and Th2 responses 
      by B. breve are associated with protection against allergic inflammation, and to 
      identify a dose-response association in a murine AR model. Ovalbumin 
      (OVA)-sensitized BALB/c mice were orally treated with different doses of B. breve 
      [10(10), 10(9), 10(7) and 10(5) colony forming units (CFU)]. Following nasal 
      challenge with OVA, sneeze frequency, serum OVA-specific immunoglobulin E (IgE) 
      and cytokine concentrations [interleukin (IL)-4, IL-10, IL-13 and interferon-gamma], 
      splenic percentage of cluster of differentiation (CD)4+CD25+ Tregs, and 
      morphology of the nasal mucosa were examined. Oral treatment with live B. breve 
      at doses of 10(7) CFU or higher alleviated nasal mucosal injury and suppressed 
      sneezing upon repeated administration over a 6-week period. Furthermore, 
      treatment with B. breve at these higher doses reduced the concentrations of serum 
      OVA-specific IgE, IL-4 and IL-10, and increased the splenic percentage of 
      CD4+CD25+ Tregs in rhinitic mice compared with those who did not receive 
      probiotics. In contrast, treatment with B. breve at a lower dose did not indicate 
      any effect on sneezing frequency or mucosal morphology in this animal model, even 
      though the splenic percentage of CD4+CD25+ Tregs increased and the concentrations 
      of serum OVA-specific IgE and IL-10 declined. B. breve exerts its anti-allergic 
      effects by inhibiting type 2 helper T cell immune responses and enhancing 
      CD4+CD25+ Treg activity. Sneezing was also reduced at a dose of 10(7) CFU or 
      higher. The current study investigated the role of B. breve and aided in 
      identifying the optimal dose of B. breve administration in the treatment of AR.
FAU - Ren, Jianjun
AU  - Ren J
AD  - Department of Otorhinolaryngology, West China Hospital, West China Medical 
      School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
FAU - Zhao, Yu
AU  - Zhao Y
AD  - Department of Otorhinolaryngology, West China Hospital, West China Medical 
      School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
FAU - Huang, Shi
AU  - Huang S
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of Chengdu Medical College, Chengdu, Sichuan 610000, P.R. China.
FAU - Lv, Dan
AU  - Lv D
AD  - Department of Otorhinolaryngology, West China Hospital, West China Medical 
      School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
FAU - Yang, Fengling
AU  - Yang F
AD  - Department of Otorhinolaryngology, West China Hospital, West China Medical 
      School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
FAU - Lou, Lin
AU  - Lou L
AD  - Department of Otorhinolaryngology, West China Hospital, West China Medical 
      School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
FAU - Zheng, Yongbo
AU  - Zheng Y
AD  - Department of Otorhinolaryngology, West China Hospital, West China Medical 
      School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Upper Airways Research Laboratory, West China Hospital, Sichuan University, 
      Chengdu, Sichuan 610041, P.R. China.
FAU - Liu, Shixi
AU  - Liu S
AD  - Upper Airways Research Laboratory, West China Hospital, Sichuan University, 
      Chengdu, Sichuan 610041, P.R. China.
FAU - Zhang, Nan
AU  - Zhang N
AD  - Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent 
      University, 9000 Ghent, Belgium.
FAU - Bachert, Claus
AU  - Bachert C
AD  - Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent 
      University, 9000 Ghent, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20180906
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6176161
OTO - NOTNLM
OT  - Bifidobacterium breve
OT  - allergic rhinitis
OT  - probiotics
OT  - regulatory T cells
EDAT- 2018/10/23 06:00
MHDA- 2018/10/23 06:01
PMCR- 2018/09/06
CRDT- 2018/10/23 06:00
PHST- 2017/12/19 00:00 [received]
PHST- 2018/05/17 00:00 [accepted]
PHST- 2018/10/23 06:00 [entrez]
PHST- 2018/10/23 06:00 [pubmed]
PHST- 2018/10/23 06:01 [medline]
PHST- 2018/09/06 00:00 [pmc-release]
AID - ETM-0-0-6704 [pii]
AID - 10.3892/etm.2018.6704 [doi]
PST - ppublish
SO  - Exp Ther Med. 2018 Nov;16(5):3996-4004. doi: 10.3892/etm.2018.6704. Epub 2018 Sep 
      6.