PMID- 30345308 OWN - NLM STAT- MEDLINE DCOM- 20190123 LR - 20190123 IS - 2314-6141 (Electronic) IS - 2314-6133 (Print) VI - 2018 DP - 2018 TI - Registration-Based Organ Positioning and Joint Segmentation Method for Liver and Tumor Segmentation. PG - 8536854 LID - 10.1155/2018/8536854 [doi] LID - 8536854 AB - The automated segmentation of liver and tumor from CT images is of great importance in medical diagnoses and clinical treatment. However, accurate and automatic segmentation of liver and tumor is generally complicated due to the complex anatomical structures and low contrast. This paper proposes a registration-based organ positioning (ROP) and joint segmentation method for liver and tumor segmentation from CT images. First, a ROP method is developed to obtain liver's bounding box accurately and efficiently. Second, a joint segmentation method based on fuzzy c-means (FCM) and extreme learning machine (ELM) is designed to perform coarse liver segmentation. Third, the coarse segmentation is regarded as the initial contour of active contour model (ACM) to refine liver boundary by considering the topological information. Finally, tumor segmentation is performed using another ELM. Experiments on two datasets demonstrate the performance advantages of our proposed method compared with other related works. FAU - Jiang, Huiyan AU - Jiang H AUID- ORCID: 0000-0002-1428-8776 AD - Department of Software College, Northeastern University, Shenyang 110819, China. FAU - Li, Shaojie AU - Li S AUID- ORCID: 0000-0003-1004-9986 AD - Department of Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang 110819, China. FAU - Li, Siqi AU - Li S AD - Department of Software College, Northeastern University, Shenyang 110819, China. LA - eng PT - Journal Article DEP - 20180924 PL - United States TA - Biomed Res Int JT - BioMed research international JID - 101600173 SB - IM MH - *Databases, Factual MH - *Fuzzy Logic MH - Humans MH - Liver/*diagnostic imaging MH - Liver Neoplasms/*diagnostic imaging MH - *Machine Learning MH - Tomography, X-Ray Computed/*methods PMC - PMC6174803 EDAT- 2018/10/23 06:00 MHDA- 2019/01/24 06:00 PMCR- 2018/09/24 CRDT- 2018/10/23 06:00 PHST- 2018/04/19 00:00 [received] PHST- 2018/07/18 00:00 [revised] PHST- 2018/09/02 00:00 [accepted] PHST- 2018/10/23 06:00 [entrez] PHST- 2018/10/23 06:00 [pubmed] PHST- 2019/01/24 06:00 [medline] PHST- 2018/09/24 00:00 [pmc-release] AID - 10.1155/2018/8536854 [doi] PST - epublish SO - Biomed Res Int. 2018 Sep 24;2018:8536854. doi: 10.1155/2018/8536854. eCollection 2018.