PMID- 30345532
OWN - NLM
STAT- MEDLINE
DCOM- 20200317
LR  - 20200317
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 91
IP  - 4
DP  - 2019 Apr
TI  - Human leukocyte antigen polymorphisms and Kaposi's sarcoma-associated herpesvirus 
      infection outcomes: A call for deeper exploration.
PG  - 541-548
LID - 10.1002/jmv.25342 [doi]
AB  - Host genetic background may influence the immunity to resist viral infection. As 
      the most polymorphic loci in the entire human genome, the human leukocyte antigen 
      (HLA) system plays an important role in innate and adaptive immune responses to 
      many invading pathogens. Studies have shown that an association might exist 
      between HLA polymorphisms and susceptibility to Kaposi's sarcoma-associated 
      herpesvirus (KSHV) infection and associated diseases. However, discrepant 
      conclusions were reached among different subjects with different detection 
      methods. Therefore, it is now urgent to summarize current results and figure out 
      the achievements and deficiencies of the existing research for the reference to 
      future studies. A better understanding about the role of HLA polymorphisms in 
      KSHV infection outcome would enable us to elucidate the pathways through which 
      the virus evades the host defense system and improve strategies for the 
      prevention and treatment of KSHV infection.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Fang, Qiwen
AU  - Fang Q
AUID- ORCID: 0000-0001-5895-442X
AD  - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 
      China.
AD  - Key Laboratory of Public Health Safety (Fudan University), Ministry of Education, 
      China.
FAU - Liu, Zhenqiu
AU  - Liu Z
AD  - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 
      China.
AD  - Key Laboratory of Public Health Safety (Fudan University), Ministry of Education, 
      China.
FAU - Zhang, Tiejun
AU  - Zhang T
AUID- ORCID: 0000-0002-5187-7393
AD  - Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 
      China.
AD  - Key Laboratory of Public Health Safety (Fudan University), Ministry of Education, 
      China.
AD  - Collaborative Innovation Center of Social Risks Governance in Health, Fudan 
      University, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20181113
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Herpesviridae Infections/*genetics/*immunology
MH  - Herpesvirus 8, Human/*genetics/*immunology
MH  - Humans
MH  - *Polymorphism, Genetic
OTO - NOTNLM
OT  - Kaposi's sarcoma (KS)
OT  - allele
OT  - human leukocyte antigen (HLA)
OT  - polymorphisms
EDAT- 2018/10/23 06:00
MHDA- 2020/03/18 06:00
CRDT- 2018/10/23 06:00
PHST- 2018/07/14 00:00 [received]
PHST- 2018/10/08 00:00 [accepted]
PHST- 2018/10/23 06:00 [pubmed]
PHST- 2020/03/18 06:00 [medline]
PHST- 2018/10/23 06:00 [entrez]
AID - 10.1002/jmv.25342 [doi]
PST - ppublish
SO  - J Med Virol. 2019 Apr;91(4):541-548. doi: 10.1002/jmv.25342. Epub 2018 Nov 13.