PMID- 30346090
OWN - NLM
STAT- MEDLINE
DCOM- 20200330
LR  - 20200330
IS  - 1440-1797 (Electronic)
IS  - 1320-5358 (Linking)
VI  - 24
IP  - 11
DP  - 2019 Nov
TI  - Effects of neutrophil-lymphocyte ratio on renal function and histologic lesions 
      in patients with diabetic nephropathy.
PG  - 1115-1121
LID - 10.1111/nep.13517 [doi]
AB  - AIM: Chronic low-grade inflammation related to diabetic nephropathy (DN) may 
      affect the serum neutrophil-lymphocyte ratio (NLR). We aimed to examine the 
      cross-sectional relationships of NLR with renal function and structural lesions 
      of DN in patients with type 2 diabetes mellitus (T2DM). METHODS: The study 
      retrospectively included 247 patients with T2DM and biopsy-proven DN. The 
      severity of different pathological lesions was evaluated based on the criteria of 
      Renal Pathology Society. The patients were divided into two groups based on the 
      median (2.42) of NLR level, group 1: NLR < 2.42 (n = 122) and group 2: NLR >/= 2.42 
      (n = 125). Renal dysfunction was defined by estimated glomerular filtration rate 
      less than 60 mL/min per 1.73 m(2) . The influence of NLR on renal dysfunction was 
      evaluated using logistic regression analysis. RESULTS: The spearman's 
      rank-correlation test indicted that NLR was positively correlated with 
      interstitial fibrosis and tubular atrophy (r = 0.170, P = 0.007) and serum 
      fibrinogen (r = 0.261, P < 0.001), whereas negatively related with estimated 
      glomerular filtration rate (r = -0.233, P < 0.001). However, the NLR level 
      demonstrated no association with glomerular lesions, interstitial inflammation 
      and arteriolar hyalinosis. A multivariate logistic regression analysis showed 
      that higher level of NLR (>/=2.42) was significantly associated with renal 
      dysfunction when adjusting for some important baseline clinical and pathological 
      variables (odds ratio, 2.46; 95% confidence interval, 1.21-4.97; P = 0.012). 
      CONCLUSION: Increased NLR affects renal function and histologic lesions in 
      patients with T2DM and may be an important factor for the progression of DN.
CI  - (c) 2018 Asian Pacific Society of Nephrology.
FAU - Zhang, Junlin
AU  - Zhang J
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Zhang, Rui
AU  - Zhang R
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Wang, Yiting
AU  - Wang Y
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Wu, Yucheng
AU  - Wu Y
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Li, Hanyu
AU  - Li H
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Han, Qianqian
AU  - Han Q
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Guo, Ruikun
AU  - Guo R
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Wang, Tingli
AU  - Wang T
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Wang, Jiali
AU  - Wang J
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Grung, Pramesh
AU  - Grung P
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Liu, Fang
AU  - Liu F
AUID- ORCID: 0000-0003-1121-3004
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      China.
LA  - eng
GR  - 81670662/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20190429
PL  - Australia
TA  - Nephrology (Carlton)
JT  - Nephrology (Carlton, Vic.)
JID - 9615568
SB  - IM
MH  - Cross-Sectional Studies
MH  - Diabetic Nephropathies/blood/pathology/*physiopathology
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Kidney/pathology/*physiopathology
MH  - Logistic Models
MH  - *Lymphocytes
MH  - Male
MH  - Middle Aged
MH  - *Neutrophils
MH  - Retrospective Studies
OTO - NOTNLM
OT  - diabetic nephropathy
OT  - histologic lesion
OT  - neutrophil-lymphocyte ratio
OT  - renal function
OT  - type 2 diabetes mellitus
EDAT- 2018/10/23 06:00
MHDA- 2020/03/31 06:00
CRDT- 2018/10/23 06:00
PHST- 2018/10/16 00:00 [accepted]
PHST- 2018/10/23 06:00 [pubmed]
PHST- 2020/03/31 06:00 [medline]
PHST- 2018/10/23 06:00 [entrez]
AID - 10.1111/nep.13517 [doi]
PST - ppublish
SO  - Nephrology (Carlton). 2019 Nov;24(11):1115-1121. doi: 10.1111/nep.13517. Epub 
      2019 Apr 29.