PMID- 30346370
OWN - NLM
STAT- MEDLINE
DCOM- 20200313
LR  - 20200313
IS  - 1532-0987 (Electronic)
IS  - 0891-3668 (Linking)
VI  - 38
IP  - 3
DP  - 2019 Mar
TI  - No Association Between Ljungan Virus Seropositivity and the Beta-cell Damaging 
      Process in the Finnish Type 1 Diabetes Prediction and Prevention Study Cohort.
PG  - 314-316
LID - 10.1097/INF.0000000000002201 [doi]
AB  - BACKGROUND: Ljungan virus (LV) has not confirmed to associate with any human 
      disease, but a possible connection with type 1 diabetes has been suggested. LV is 
      a rodent-borne picornavirus that induces a diabetes-like condition in rodents. 
      Approximately 30% of adults and 60% of children are seropositive in Finland. The 
      Finnish Type 1 Diabetes Prediction and Prevention study enabled the use of very 
      well characterized sample panels from children seroconverted to positivity for 
      multiple islet autoantibodies during their prospective observation from birth; in 
      addition, samples from age, sex, human leukocyte antigen (HLA), and residence 
      area matched control children. METHODS: We analyzed LV IgG seroprevalence in 102 
      case children (65 had also developed type 1 diabetes), in addition to nondiabetic 
      control children. LV and human parechovirus (HPeV) immunofluorescence assays were 
      used to analyze LV and HPeV-specific IgG from 102 plasma samples taken at the 
      time of islet autoantibody appearance and from 204 samples from the matched 
      control children. RESULTS: Altogether 46.1% of the case and 50.7% of the control 
      children were positive for LV IgG (odds ratio 0.8; 95% confidence interval, 
      0.47-1.36; P = 0.416) and 67.6% versus 79.8% were positive for HPeV IgG, 
      respectively (odds ratio 0.49, 0.27-0.9, P = 0.023). CONCLUSIONS: Thus, no risk 
      associations between LV or HPeV-specific IgG and islet autoimmunity were 
      observed. However, a trend for significantly higher prevalence of HPeV antibodies 
      in control children (P = 0.023) suggests a possible protective association of 
      this virus with islet autoimmunity.
FAU - Jaaskelainen, Anne J
AU  - Jaaskelainen AJ
AD  - From the Department of Virology, Helsinki University and Helsinki University 
      Hospital (HUSLAB), Finland.
FAU - Nurminen, Noora
AU  - Nurminen N
AD  - Department of Virology, School of Medicine, University of Tampere, Tampere, 
      Finland.
FAU - Kolehmainen, Pekka
AU  - Kolehmainen P
AD  - From the Department of Virology, Helsinki University and Helsinki University 
      Hospital (HUSLAB), Finland.
AD  - Department of Virology, University of Turku, Turku, Finland.
FAU - Smura, Teemu
AU  - Smura T
AD  - From the Department of Virology, Helsinki University and Helsinki University 
      Hospital (HUSLAB), Finland.
FAU - Tauriainen, Sisko
AU  - Tauriainen S
AD  - Department of Virology, University of Turku, Turku, Finland.
FAU - Toppari, Jorma
AU  - Toppari J
AD  - Department of Physiology, Institute of Biomedicine, University of Turku, Turku, 
      Finland.
AD  - Department of Pediatrics, Turku University Hospital, Turku, Finland.
FAU - Ilonen, Jorma
AU  - Ilonen J
AD  - Immunogenetics Laboratory, University of Turku and Turku University Hospital, 
      Turku, Finland.
FAU - Veijola, Riitta
AU  - Veijola R
AD  - Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, Oulu 
      University Hospital and University of Oulu, Oulu, Finland.
FAU - Knip, Mikael
AU  - Knip M
AD  - Children's Hospital, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
AD  - Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, 
      Finland.
AD  - Folkhalsan Research Center, Helsinki, Finland.
AD  - Tampere Center for Child Health Research, Tampere University Hospital, Tampere, 
      Finland.
FAU - Hyoty, Heikki
AU  - Hyoty H
AD  - Department of Virology, School of Medicine, University of Tampere, Tampere, 
      Finland.
AD  - Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland.
FAU - Vapalahti, Olli
AU  - Vapalahti O
AD  - From the Department of Virology, Helsinki University and Helsinki University 
      Hospital (HUSLAB), Finland.
AD  - Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, Oulu 
      University Hospital and University of Oulu, Oulu, Finland.
FAU - Kallio-Kokko, Hannimari
AU  - Kallio-Kokko H
AD  - From the Department of Virology, Helsinki University and Helsinki University 
      Hospital (HUSLAB), Finland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
RN  - 0 (Antibodies, Viral)
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Antibodies, Viral/*blood
MH  - Autoantibodies/blood
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/*virology
MH  - Female
MH  - Finland/epidemiology
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Insulin-Secreting Cells/*pathology/virology
MH  - Male
MH  - Parechovirus/genetics/*immunology
MH  - Prospective Studies
MH  - Seroepidemiologic Studies
EDAT- 2018/10/23 06:00
MHDA- 2020/03/14 06:00
CRDT- 2018/10/23 06:00
PHST- 2018/10/23 06:00 [pubmed]
PHST- 2020/03/14 06:00 [medline]
PHST- 2018/10/23 06:00 [entrez]
AID - 10.1097/INF.0000000000002201 [doi]
PST - ppublish
SO  - Pediatr Infect Dis J. 2019 Mar;38(3):314-316. doi: 10.1097/INF.0000000000002201.