PMID- 30346430
OWN - NLM
STAT- MEDLINE
DCOM- 20190531
LR  - 20190531
IS  - 1997-7298 (Print)
IS  - 1997-7298 (Linking)
VI  - 118
IP  - 6. Vyp. 2
DP  - 2018
TI  - [Cognitive disorders in the middle-aged population and cerebrovascular risk 
      factors].
PG  - 27-31
LID - 10.17116/jnevro201811806227 [doi]
AB  - AIM: To study the frequency of subjective and objective cognitive disorders in 
      the middle-aged population and their associations with main and additional 
      cerebrovascular risk factors. MATERIAL AND METHODS: The authors examined 169 men 
      and 239 women aged 40-59 years. Medical history study, blood tests, 
      electrocardiography, brachiocephalic and common femoral arteries scan, 
      echocardiography, magnetic resonance imaging of the brain (MRI) were performed. 
      Luria and Munsterberg tests were done to assess cognitive dysfunction. Affective 
      disorders were assessed by the Hospital scale of anxiety and depression. RESULTS 
      AND CONCLUSION: Absence of subjective (SCI) and/or objective (OCI) cognitive 
      impairments was found in 26,5%; 10% had purely SCI, more than 35,7% of complaints 
      were accompanied by deviations in neuropsychological test results (OCI+), over 
      25% had only OCI-. The average age of patients with OCI+ was higher than in the 
      control group. In women, the frequency of SCI was twice as high and OCI less 
      frequent as in men. Absence of cognitive impairment and SCI were observed more 
      frequently in individuals with higher education. The prevalence of multiple white 
      matter lesions (WML) in MRI was 36%. Multiple WML and atherosclerosis of major 
      arteries were more common in OCI+ group (47%). Mild affective disorders were more 
      frequent in the studied groups. Anxiety disorders were more common than 
      depressive ones. The amount of patients with affective disorders was highest in 
      OCI+. Therefore, SCI is a common phenomenon among people aged 40-60 years. The 
      use of simple neuropsychological tests in screening examination allows to 
      identify individuals who are most appropriate for active search for vascular risk 
      factors. Anxiety and depressive disorders cause a significant proportion of SCI 
      among middle-aged people and are an important additional target for therapeutic 
      measures.
FAU - Gnedovskaya, E V
AU  - Gnedovskaya EV
AD  - Research Center of Neurology, Moscow, Russia.
FAU - Kravchenko, M A
AU  - Kravchenko MA
AD  - Research Center of Neurology, Moscow, Russia.
FAU - Nikolaeva, N S
AU  - Nikolaeva NS
AD  - Research Center of Neurology, Moscow, Russia.
FAU - Chechetkin, A O
AU  - Chechetkin AO
AD  - Research Center of Neurology, Moscow, Russia.
FAU - Krotenkova, M V
AU  - Krotenkova MV
AD  - Research Center of Neurology, Moscow, Russia.
FAU - Varakin, Yu Ya
AU  - Varakin YY
AD  - Research Center of Neurology, Moscow, Russia.
LA  - rus
PT  - Journal Article
TT  - Kognitivnye narusheniia u lits srednego vozrasta i faktory riska 
      tserebrovaskuliarnykh zabolevanii.
PL  - Russia (Federation)
TA  - Zh Nevrol Psikhiatr Im S S Korsakova
JT  - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
JID - 9712194
SB  - IM
MH  - Adult
MH  - Cerebrovascular Disorders
MH  - Cognition
MH  - *Cognition Disorders
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Risk Factors
OTO - NOTNLM
OT  - anxiety
OT  - cerebrovascular disease
OT  - depression
OT  - memory loss
OT  - prevalence
OT  - risk factors
OT  - subjective cognitive impairment
EDAT- 2018/10/23 06:00
MHDA- 2019/06/01 06:00
CRDT- 2018/10/23 06:00
PHST- 2018/10/23 06:00 [entrez]
PHST- 2018/10/23 06:00 [pubmed]
PHST- 2019/06/01 06:00 [medline]
AID - 10.17116/jnevro201811806227 [doi]
PST - ppublish
SO  - Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(6. Vyp. 2):27-31. doi: 
      10.17116/jnevro201811806227.