PMID- 30346599
OWN - NLM
STAT- MEDLINE
DCOM- 20191218
LR  - 20191218
IS  - 1550-9109 (Electronic)
IS  - 0161-8105 (Linking)
VI  - 42
IP  - 1
DP  - 2019 Jan 1
TI  - Objective sleep duration is associated with cognitive deficits in primary 
      insomnia: BDNF may play a role.
LID - 10.1093/sleep/zsy192 [doi]
AB  - STUDY OBJECTIVES: Objective sleep duration has been linked to insomnia severity. 
      However, cognitive functions of people with insomnia with different sleep 
      durations have been seldom addressed. Brain-derived neurotrophic factor (BDNF) 
      has an important role in cognitive function and has been linked to clinical 
      insomnia recently. The present study aimed to evaluate the comprehensive 
      cognitive functions in people with primary insomnia with different objective 
      sleep durations, and further examine the involvement of peripheral BDNF. METHODS: 
      Fifty-seven people with insomnia were subdivided into short sleep duration (SSD, 
      sleep time < 6 hr) group and normal sleep duration (NSD, sleep time >/= 6 hr) group 
      based on polysomnography data. Twenty-nine healthy controls (HC) were matched on 
      age, gender, and education. Cognitive function was assessed using a comprehensive 
      and sensitive neuropsychological test battery. Both objective and subjective 
      insomnia statuses were estimated. Serum BDNF level was measured using 
      enzyme-linked immune sorbent assay. RESULTS: Compared with HC, the SSD group 
      showed impaired neuropsychological performances in spatial span, brief 
      visuospatial memory test, fluency, managing emotions, and continuous performance 
      tests. In contrast, NSD had bad performance only in brief visuospatial memory 
      test and continuous performance tests, and relatively better than SSD group in 
      the latter test. People with SSD insomnia but not NSD had decreased BDNF levels 
      compared with HC, and neuropsychological performance was positively correlated 
      with BDNF levels only in SSD group. CONCLUSIONS: Primary insomnia was associated 
      with impaired neuropsychological performance, and the impairment might be related 
      to decreased objective sleep duration. In addition, decreased peripheral BDNF 
      might mediate the impaired cognitive functions of people with insomnia with SSD.
FAU - Fan, Teng-Teng
AU  - Fan TT
AD  - Peking University Sixth Hospital, Peking University Institute of Mental Health, 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), National 
      Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), 
      Beijing, China.
FAU - Chen, Wen-Hao
AU  - Chen WH
AD  - Peking University Sixth Hospital, Peking University Institute of Mental Health, 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), National 
      Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), 
      Beijing, China.
FAU - Shi, Le
AU  - Shi L
AD  - Peking University Sixth Hospital, Peking University Institute of Mental Health, 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), National 
      Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), 
      Beijing, China.
AD  - National Institute on Drug Dependence and Beijing Key laboratory of Drug 
      Dependence Research, Peking University, Beijing, China.
FAU - Lin, Xiao
AU  - Lin X
AD  - Peking University Sixth Hospital, Peking University Institute of Mental Health, 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), National 
      Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), 
      Beijing, China.
AD  - Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain 
      Research, Peking University, Beijing, China.
FAU - Tabarak, Serik
AU  - Tabarak S
AD  - Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain 
      Research, Peking University, Beijing, China.
FAU - Chen, Si-Jing
AU  - Chen SJ
AD  - Peking University Sixth Hospital, Peking University Institute of Mental Health, 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), National 
      Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), 
      Beijing, China.
FAU - Que, Jian-Yu
AU  - Que JY
AD  - Peking University Sixth Hospital, Peking University Institute of Mental Health, 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), National 
      Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), 
      Beijing, China.
FAU - Bao, Yan-Ping
AU  - Bao YP
AD  - National Institute on Drug Dependence and Beijing Key laboratory of Drug 
      Dependence Research, Peking University, Beijing, China.
FAU - Tang, Xiang-Dong
AU  - Tang XD
AD  - Sleep Medicine Center, West China Hospital, Sichuan University, Sichuan 610041, 
      China.
FAU - Shi, Jie
AU  - Shi J
AD  - National Institute on Drug Dependence and Beijing Key laboratory of Drug 
      Dependence Research, Peking University, Beijing, China.
FAU - Lu, Lin
AU  - Lu L
AD  - Peking University Sixth Hospital, Peking University Institute of Mental Health, 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), National 
      Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), 
      Beijing, China.
AD  - Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain 
      Research, Peking University, Beijing, China.
FAU - Sun, Hong-Qiang
AU  - Sun HQ
AD  - Peking University Sixth Hospital, Peking University Institute of Mental Health, 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), National 
      Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), 
      Beijing, China.
FAU - Liu, Jia Jia
AU  - Liu JJ
AD  - Peking University Sixth Hospital, Peking University Institute of Mental Health, 
      Key Laboratory of Mental Health, Ministry of Health (Peking University), National 
      Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), 
      Beijing, China.
AD  - National Institute on Drug Dependence and Beijing Key laboratory of Drug 
      Dependence Research, Peking University, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Sleep
JT  - Sleep
JID - 7809084
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition/*physiology
MH  - Cognitive Dysfunction/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Memory/physiology
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Play and Playthings
MH  - Polysomnography
MH  - Sleep/*physiology
MH  - Sleep Initiation and Maintenance Disorders/*physiopathology/*psychology
MH  - Surveys and Questionnaires
MH  - Time Factors
EDAT- 2018/10/23 06:00
MHDA- 2019/12/19 06:00
CRDT- 2018/10/23 06:00
PHST- 2018/01/18 00:00 [received]
PHST- 2018/10/23 06:00 [pubmed]
PHST- 2019/12/19 06:00 [medline]
PHST- 2018/10/23 06:00 [entrez]
AID - 5140131 [pii]
AID - 10.1093/sleep/zsy192 [doi]
PST - ppublish
SO  - Sleep. 2019 Jan 1;42(1). doi: 10.1093/sleep/zsy192.