PMID- 30347311 OWN - NLM STAT- MEDLINE DCOM- 20190315 LR - 20190315 IS - 1879-0046 (Electronic) IS - 0376-8716 (Linking) VI - 193 DP - 2018 Dec 1 TI - Brain-derived neurotrophic factor in substance use disorders: A systematic review and meta-analysis. PG - 91-103 LID - S0376-8716(18)30725-7 [pii] LID - 10.1016/j.drugalcdep.2018.08.036 [doi] AB - BACKGROUND: Brain-derived neurotrophic factor (BDNF) is associated with several neurodegenerative and psychiatric disorders. It is not clear, however, whether BDNF levels are modified in substance use disorders (SUDs). METHODS: We conducted a systematic search of electronic databases to identify studies comparing peripheral plasma or serum BDNF levels in adults with SUDs vs. non-user controls. Forty studies were included in the meta-analysis involving a total of 2238 participants with SUDs and 2574 controls. RESULTS: After trim and fill adjustment, current drug users presented lower serum BDNF levels (SMD = -0.99, 95%CI -1.40 to -0.58, I(2) = 95.9) than non-user controls. However, this difference disappears during withdrawal. Studies using serum or plasma BDNF samples have shown different results. Subgroup analysis revealed lower levels of serum BDNF in alcohol users (SMD = -0.70, 95%CI -1.15 to -0.25, I(2) = 89.81) and crack/cocaine users (SMD = -1.78, 95%CI -2.92 to -0.65, I(2) = 97.59) than controls. Meta-regression analysis revealed that gender, age, and age of first use moderate the effects of drug use in peripheral BDNF levels. CONCLUSIONS: Peripheral BDNF levels are decreased in the serum, but not the plasma, of active drug users. Altogether, these findings suggest that BDNF levels may be related to acute use and addiction severity and also point to BDNF's potential utility as a biomarker in this population. CI - Copyright (c) 2018 Elsevier B.V. All rights reserved. FAU - Ornell, Felipe AU - Ornell F AD - Center for Drug and Alcohol Research and Collaborating Center on Alcohol and Drugs, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Professor Alvaro Alvim, 400, 90420-020, Porto Alegre, RS, Brazil; Postgraduate Program in Psychiatry and Behavioral Science, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: fornell@hcpa.edu.br. FAU - Hansen, Fernanda AU - Hansen F AD - Center for Drug and Alcohol Research and Collaborating Center on Alcohol and Drugs, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Professor Alvaro Alvim, 400, 90420-020, Porto Alegre, RS, Brazil; Department of Nutrition, Health Sciences Center, Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Schuch, Felipe Barreto AU - Schuch FB AD - Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil; Universidade La Salle, Porto Alegre, RS, Brazil. FAU - Pezzini Rebelatto, Fernando AU - Pezzini Rebelatto F AD - Center for Drug and Alcohol Research and Collaborating Center on Alcohol and Drugs, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Professor Alvaro Alvim, 400, 90420-020, Porto Alegre, RS, Brazil. FAU - Tavares, Ana Laura AU - Tavares AL AD - Center for Drug and Alcohol Research and Collaborating Center on Alcohol and Drugs, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Professor Alvaro Alvim, 400, 90420-020, Porto Alegre, RS, Brazil. FAU - Scherer, Juliana Nichterwitz AU - Scherer JN AD - Center for Drug and Alcohol Research and Collaborating Center on Alcohol and Drugs, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Professor Alvaro Alvim, 400, 90420-020, Porto Alegre, RS, Brazil; Postgraduate Program in Psychiatry and Behavioral Science, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. FAU - Valerio, Andrei Garziera AU - Valerio AG AD - Center for Drug and Alcohol Research and Collaborating Center on Alcohol and Drugs, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Professor Alvaro Alvim, 400, 90420-020, Porto Alegre, RS, Brazil. FAU - Pechansky, Flavio AU - Pechansky F AD - Center for Drug and Alcohol Research and Collaborating Center on Alcohol and Drugs, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Professor Alvaro Alvim, 400, 90420-020, Porto Alegre, RS, Brazil; Postgraduate Program in Psychiatry and Behavioral Science, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. FAU - Paim Kessler, Felix Henrique AU - Paim Kessler FH AD - Center for Drug and Alcohol Research and Collaborating Center on Alcohol and Drugs, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Professor Alvaro Alvim, 400, 90420-020, Porto Alegre, RS, Brazil; Postgraduate Program in Psychiatry and Behavioral Science, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. FAU - von Diemen, Lisia AU - von Diemen L AD - Center for Drug and Alcohol Research and Collaborating Center on Alcohol and Drugs, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Professor Alvaro Alvim, 400, 90420-020, Porto Alegre, RS, Brazil; Postgraduate Program in Psychiatry and Behavioral Science, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20181012 PL - Ireland TA - Drug Alcohol Depend JT - Drug and alcohol dependence JID - 7513587 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - Biomarkers/blood MH - Brain-Derived Neurotrophic Factor/*blood MH - Drug Users MH - Humans MH - Substance-Related Disorders/*blood OTO - NOTNLM OT - Alcohol OT - Biomarker OT - Brain-derived neurotrophic factor OT - Crack-cocaine OT - Meta-analysis OT - Substance use disorder EDAT- 2018/10/23 06:00 MHDA- 2019/03/16 06:00 CRDT- 2018/10/23 06:00 PHST- 2018/06/15 00:00 [received] PHST- 2018/08/23 00:00 [revised] PHST- 2018/08/29 00:00 [accepted] PHST- 2018/10/23 06:00 [pubmed] PHST- 2019/03/16 06:00 [medline] PHST- 2018/10/23 06:00 [entrez] AID - S0376-8716(18)30725-7 [pii] AID - 10.1016/j.drugalcdep.2018.08.036 [doi] PST - ppublish SO - Drug Alcohol Depend. 2018 Dec 1;193:91-103. doi: 10.1016/j.drugalcdep.2018.08.036. Epub 2018 Oct 12.