PMID- 30348302
OWN - NLM
STAT- MEDLINE
DCOM- 20190301
LR  - 20190301
IS  - 1523-1755 (Electronic)
IS  - 0085-2538 (Linking)
VI  - 94
IP  - 5
DP  - 2018 Nov
TI  - Deep pockets are not necessarily a good thing in membranous nephropathy: evidence 
      for a modifier allele.
PG  - 855-857
LID - S0085-2538(18)30488-5 [pii]
LID - 10.1016/j.kint.2018.07.010 [doi]
AB  - Risk (or susceptibility) alleles for primary membranous nephropathy exist within 
      the DQ and DR loci of the human leukocyte antigen (HLA) region of chromosome 6. 
      The discussed study identifies a novel allele, HLA DRB1*1502, in a Han Chinese 
      cohort that acts as a modifier allele by associating not with the phenotype of 
      membranous nephropathy, but rather with the severity of disease. This commentary 
      addresses the potential biologic aspects of these new data.
CI  - Copyright (c) 2018 International Society of Nephrology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Beck, Laurence H Jr
AU  - Beck LH Jr
AD  - Department of Medicine, Renal Section, Boston University School of Medicine and 
      Boston Medical Center, Boston, Massachusetts, USA. Electronic address: 
      lhbeckjr@bu.edu.
FAU - Salant, David J
AU  - Salant DJ
AD  - Department of Medicine, Renal Section, Boston University School of Medicine and 
      Boston Medical Center, Boston, Massachusetts, USA.
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (Amino Acids)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
CON - Kidney Int. 2018 Nov;94(5):974-982. PMID: 30173899
MH  - *Alleles
MH  - Amino Acids/genetics
MH  - Glomerulonephritis, Membranous/*genetics
MH  - HLA Antigens
MH  - HLA-DRB1 Chains/genetics
MH  - Humans
MH  - Phenotype
EDAT- 2018/10/24 06:00
MHDA- 2019/03/02 06:00
CRDT- 2018/10/24 06:00
PHST- 2018/06/29 00:00 [received]
PHST- 2018/07/03 00:00 [accepted]
PHST- 2018/10/24 06:00 [entrez]
PHST- 2018/10/24 06:00 [pubmed]
PHST- 2019/03/02 06:00 [medline]
AID - S0085-2538(18)30488-5 [pii]
AID - 10.1016/j.kint.2018.07.010 [doi]
PST - ppublish
SO  - Kidney Int. 2018 Nov;94(5):855-857. doi: 10.1016/j.kint.2018.07.010.