PMID- 30349267
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 14
DP  - 2018
TI  - The effect of different frequencies of electroacupuncture on BDNF and NGF 
      expression in the hippocampal CA3 area of the ischemic hemisphere in cerebral 
      ischemic rats.
PG  - 2689-2696
LID - 10.2147/NDT.S183436 [doi]
AB  - OBJECTIVE: The aim of this study was to observe the effects of different 
      frequencies of electroacupuncture (EA) on expression of brain-derived 
      neurotrophic factor (BDNF) and nerve growth factor (NGF) in the hippocampal CA3 
      region of cerebral ischemic rats. METHODS: Middle cerebral artery occlusion was 
      successfully introduced to simulate cerebral infarction in 48 healthy male 
      Sprague-Dawley rats. Totally, 48 rats were randomly divided into three groups: 
      the control group, the EA 5-Hz group, and the EA 50-Hz group, 16 in each group. 
      The rats in the control group were placed in an ordinary cage and fed normally 
      without any treatment. EA treatment was given at a certain frequency 24 hours 
      after surgery in the EA 5-Hz group and EA 50-Hz group. Morris water maze test was 
      used to measure the learning and memory abilities of rats in each group after 
      14-day treatment with EA. Immunohistochemical staining was used to detect the 
      expression of BDNF- and NGF-positive cells in the ischemic hippocampal CA3 area 
      of the rats. RESULTS: The EA 5-Hz group and EA 50-Hz group had significantly 
      improved learning and memory ability compared with the control group according to 
      Morris water maze findings (P<0.05). The number of BDNF- and NGF-positive cells 
      in the hippocampal CA3 region of the ischemic hemisphere in the 5-Hz group and 
      50-Hz EA group was significantly more than that in the control group after EA 
      treatment (P<0.05), and the difference in the 50-Hz group was more obvious than 
      that in the 5-Hz group. The difference was statistically significant (P<0.05). 
      CONCLUSION: EA stimulation of "Baihui" and "Dazhui" can promote the expression of 
      BDNF and NGF in the hippocampal CA3 region of cerebral ischemic rats, and the 
      50-Hz EA stimulation effect is more obvious.
FAU - Duan, Xiaodong
AU  - Duan X
AD  - Department of Rehabilitation Medicine, Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, China, x5144@163.com; 2930773281@qq.com.
FAU - Zhang, Lei
AU  - Zhang L
AD  - School of Public Health, Southwest Medical University, Luzhou, Sichuan 646000, 
      China.
FAU - Yu, Jihua
AU  - Yu J
AD  - Department of Rehabilitation Medicine, Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, China, x5144@163.com; 2930773281@qq.com.
FAU - Wei, Wei
AU  - Wei W
AD  - Department of Neurology, Affiliated Hospital of Southwest Medical University, 
      Luzhou, Sichuan 646000, China.
FAU - Liu, Xi
AU  - Liu X
AD  - Department of Rehabilitation Medicine, Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, China, x5144@163.com; 2930773281@qq.com.
FAU - Xu, Fangyuan
AU  - Xu F
AD  - Department of Rehabilitation Medicine, Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, China, x5144@163.com; 2930773281@qq.com.
FAU - Guo, Shengmin
AU  - Guo S
AD  - Department of Rehabilitation Medicine, Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, China, x5144@163.com; 2930773281@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20181011
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC6187974
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - cerebral infarction
OT  - electroacupuncture
OT  - nerve growth factor
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2018/10/24 06:00
MHDA- 2018/10/24 06:01
PMCR- 2018/10/11
CRDT- 2018/10/24 06:00
PHST- 2018/10/24 06:00 [entrez]
PHST- 2018/10/24 06:00 [pubmed]
PHST- 2018/10/24 06:01 [medline]
PHST- 2018/10/11 00:00 [pmc-release]
AID - ndt-14-2689 [pii]
AID - 10.2147/NDT.S183436 [doi]
PST - epublish
SO  - Neuropsychiatr Dis Treat. 2018 Oct 11;14:2689-2696. doi: 10.2147/NDT.S183436. 
      eCollection 2018.