PMID- 30349376 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220408 IS - 1179-1322 (Print) IS - 1179-1322 (Electronic) IS - 1179-1322 (Linking) VI - 10 DP - 2018 TI - Response of patients with locally advanced pancreatic adenocarcinoma to high-intensity focused ultrasound treatment: a single-center, prospective, case series in China. PG - 4439-4446 LID - 10.2147/CMAR.S173740 [doi] AB - PURPOSE: Patients with unresectable locally advanced pancreatic cancer (LAPC) are still in dire need of effective therapies. We performed this cohort study in order to assess the efficacy and safety of high-intensity focused ultrasound (HIFU) ablation in treating patients with unresectable LAPC. PATIENTS AND METHODS: Eighty-seven cases with unresectable LAPC from January 2014 to December 2016 were finally recruited according to the inclusion criteria. The primary end point of our study was OS of all the cases, and the secondary end points included 6-month and 12-month survival rate, tumor response rate, carbohydrate antigen (CA) 19-9 response rate, VAS, quality of life, and safety. RESULTS: All the 87 patients received HIFU ablation successfully, and were included in the efficacy and safety analysis. With a median follow-up of 16 months, median OS was estimated to be 12.2 months, with 95 % CI of 11.1-12.7 months. The 6-month and 12-month survival rates were 94.25% (95% CI =86.74-97.57) and 50.85% (95% CI =38.17-62.21), respectively. Multivariate analysis revealed that patients with VAS <4, Karnofsky performance status >/=80, and tumor size <3 cm have a significant improvement in their OS (adjusted HR [aHR] =0.26 [95% CI =0.12-0.57], P=0.001; aHR =0.34 [95% CI =0.17-0.68], P=0.02; and aHR =0.39 [95% CI =0.20-0.78], P=0.007; respectively). Tumor responses were observed in 32 (36.8%) of 87 patients and CA 19-9 response rate was 56.2%. Global health status, physical function, emotional function, and cognitive function of patients were significantly improved after HIFU treatment, and symptoms of fatigue and pain were significantly reduced. A total of 28.7% (25/87) of patients reported adverse events (AEs), mainly including fatigue (14/87), abdominal pain (7/87), fever (7/87), nausea (5/87), and rash (4/87). No severe AEs and HIFU-related deaths were reported. CONCLUSION: HIFU ablation might be a potentially effective and safe therapeutic option for the patients with unresectable LAPC. FAU - Ji, Yongshuo AU - Ji Y AD - HIFU Center of Oncology Department, Huadong Hospital Affiliated to Fudan University, Shanghai 200000, China, hongzhhdyy@163.com. FAU - Zhang, Yu AU - Zhang Y AD - HIFU Center of Oncology Department, Huadong Hospital Affiliated to Fudan University, Shanghai 200000, China, hongzhhdyy@163.com. FAU - Zhu, Junqiu AU - Zhu J AD - HIFU Center of Oncology Department, Huadong Hospital Affiliated to Fudan University, Shanghai 200000, China, hongzhhdyy@163.com. FAU - Zhu, Linglin AU - Zhu L AD - HIFU Center of Oncology Department, Huadong Hospital Affiliated to Fudan University, Shanghai 200000, China, hongzhhdyy@163.com. FAU - Zhu, Yanfei AU - Zhu Y AD - HIFU Center of Oncology Department, Huadong Hospital Affiliated to Fudan University, Shanghai 200000, China, hongzhhdyy@163.com. FAU - Hu, Kaimeng AU - Hu K AD - Marketing Department, Shanghai A&S Science Technology Development Co., Ltd, Shanghai 200000, China. FAU - Zhao, Hong AU - Zhao H AD - HIFU Center of Oncology Department, Huadong Hospital Affiliated to Fudan University, Shanghai 200000, China, hongzhhdyy@163.com. LA - eng PT - Journal Article DEP - 20181009 PL - New Zealand TA - Cancer Manag Res JT - Cancer management and research JID - 101512700 PMC - PMC6188211 OTO - NOTNLM OT - HIFU OT - locally advanced pancreatic cancer OT - quality of life OT - response OT - survival OT - unresectable COIS- Disclosure The authors report no conflicts of interest in this work. EDAT- 2018/10/24 06:00 MHDA- 2018/10/24 06:01 PMCR- 2018/10/09 CRDT- 2018/10/24 06:00 PHST- 2018/10/24 06:00 [entrez] PHST- 2018/10/24 06:00 [pubmed] PHST- 2018/10/24 06:01 [medline] PHST- 2018/10/09 00:00 [pmc-release] AID - cmar-10-4439 [pii] AID - 10.2147/CMAR.S173740 [doi] PST - epublish SO - Cancer Manag Res. 2018 Oct 9;10:4439-4446. doi: 10.2147/CMAR.S173740. eCollection 2018.