PMID- 30349574
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1735-3955 (Print)
IS  - 2251-6638 (Electronic)
IS  - 1735-3955 (Linking)
VI  - 14
IP  - 3
DP  - 2018 May
TI  - Serum interleukin-18 and extent of coronary artery disease in unstable angina.
PG  - 122-127
LID - 10.22122/arya.v14i3.1370 [doi]
AB  - BACKGROUND: Interleukin-18 (IL-18) is an inflammatory marker with challenging 
      role in atherosclerosis. The present study was carried out aiming to evaluate the 
      association between IL-18 serum level and extent and severity of atherosclerosis 
      among young patients with unstable angina (UA) who underwent coronary 
      angiography. METHODS: This cross sectional study was performed from July to 
      October 2015 in Chamran heart center, Isfahan, Iran. 180 patients with UA in the 
      age range of below 50 years entered the study. All demographic, past history, 
      physical examination, electrocardiogram (EKG or ECG), and transthoracic 
      echocardiogram (TTE) data were collected. Serum level of IL-18 was measured using 
      enzyme-linked immunosorbent assay (ELISA) method. A coronary angiography was 
      performed on all patients to evaluate the presence and the incidence rate of 
      coronary artery disease (CAD). RESULTS: Mean age of the patients was 46.0 +/- 4.6 
      years [47.4 +/- 4.3 and 45.9 +/- 4.9 among patients with CAD and normal coronary, 
      respectively (P = 0.040)]. Rate of severe CAD was greater among men compared to 
      women with values 67.8% and 51.8%, respectively (P = 0.032). The median 
      [interquartile range (IQR)] value of serum IL-18 among patients with CAD [192.86 
      (128.03,325.75)] was higher than normal coronary subjects [172.81 
      (139.77,243.21)], however it was not significant (198.4 +/- 93.5, P = 0.287). A 
      significant difference between serum IL-18 level and number of stenosis vessels 
      was detected only among women (P = 0.032). CONCLUSION: Serum IL-18 level can 
      predict the number of coronary arteries with significant stenosis among women 
      with unstable angina.
FAU - Sadeghi, Masoumeh
AU  - Sadeghi M
AD  - Professor, Cardiac Rehabilitation Research Center, Cardiovascular Research 
      Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Gheraati, Maryam
AU  - Gheraati M
AD  - Interventional Cardiology Research Center, Cardiovascular Research Institute, 
      Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Soleimani, Azam
AU  - Soleimani A
AD  - Assistant Professor, Heart Failure Research Center, Cardiovascular Research 
      Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Amirpour, Afshin
AU  - Amirpour A
AD  - Assistant Professor, Hypertension Research Center, Cardiovascular Research 
      Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Taheri, Marzieh
AU  - Taheri M
AD  - Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, 
      Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Yazdekhasti, Safoura
AU  - Yazdekhasti S
AD  - Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, 
      Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Valikhani, Elham
AU  - Valikhani E
AD  - Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, 
      Isfahan University of Medical Sciences, Isfahan, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - ARYA Atheroscler
JT  - ARYA atherosclerosis
JID - 101487337
PMC - PMC6191574
OTO - NOTNLM
OT  - Angiography
OT  - Atherosclerosis
OT  - Interleukin-18
OT  - Unstable Angina
EDAT- 2018/10/24 06:00
MHDA- 2018/10/24 06:01
PMCR- 2018/05/01
CRDT- 2018/10/24 06:00
PHST- 2018/10/24 06:00 [entrez]
PHST- 2018/10/24 06:00 [pubmed]
PHST- 2018/10/24 06:01 [medline]
PHST- 2018/05/01 00:00 [pmc-release]
AID - ARYA-14-122 [pii]
AID - 10.22122/arya.v14i3.1370 [doi]
PST - ppublish
SO  - ARYA Atheroscler. 2018 May;14(3):122-127. doi: 10.22122/arya.v14i3.1370.