PMID- 30351423
OWN - NLM
STAT- MEDLINE
DCOM- 20200629
LR  - 20210811
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 45
IP  - 4
DP  - 2019 Jun 18
TI  - The Global Functioning: Social and Role Scales-Further Validation in a Large 
      Sample of Adolescents and Young Adults at Clinical High Risk for Psychosis.
PG  - 763-772
LID - 10.1093/schbul/sby126 [doi]
AB  - OBJECTIVE: Traditional measures for assessing functioning with adult patients 
      with schizophrenia have been shown to be insufficient for assessing the issues 
      that occur in adolescents and young adults at clinical high risk (CHR) for 
      psychosis. The current study provides an expanded validation of the Global 
      Functioning: Social (GF:Social) and Role (GF:Role) scales developed specifically 
      for use with CHR individuals and explores the reliability and accuracy of the 
      ratings, the validity of the scores in comparison to other established clinical 
      measures, stability of functioning over a 2-year period, and psychosis predictive 
      ability. METHODS: Seven hundred fifty-five CHR individuals and 277 healthy 
      control (HC) participants completed the GF:Social and Role scales at baseline as 
      part of the North American Prodrome Longitudinal Study (NAPLS2). RESULTS: 
      Inter-rater reliability and accuracy were high for both scales. Correlations 
      between the GF scores and other established clinical measures demonstrated 
      acceptable convergent and discriminant validity. In addition, GF:Social and Role 
      scores were unrelated to positive symptoms. CHR participants showed large 
      impairments in social and role functioning over 2-years, relative to the HCs, 
      even after adjusting for age, IQ, and attenuated positive symptoms. Finally, 
      social decline prior to baseline was more pronounced in CHR converters, relative 
      to non-converters. CONCLUSIONS: The GF scales can be administered in a 
      large-scale multi-site study with excellent inter-rater reliability and accuracy. 
      CHR individuals showed social and role functioning impairments over time that 
      were not confounded by positive symptom severity levels. The results of this 
      study demonstrate that social decline is a particularly effective predictor of 
      conversion outcome.
CI  - (c) The Author(s) 2018. Published by Oxford University Press on behalf of the 
      Maryland Psychiatric Research Center. All rights reserved. For permissions, 
      please email: journals.permissions@oup.com.
FAU - Carrion, Ricardo E
AU  - Carrion RE
AD  - Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell Health, 
      Glen Oaks, NY.
AD  - Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, 
      Northwell Health, Manhasset, NY.
AD  - Department of Psychiatry, Zucker School of Medicine at Hofstra/Northwell, 
      Hempstead, NY.
FAU - Auther, Andrea M
AU  - Auther AM
AD  - Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell Health, 
      Glen Oaks, NY.
AD  - Department of Psychiatry, Zucker School of Medicine at Hofstra/Northwell, 
      Hempstead, NY.
FAU - McLaughlin, Danielle
AU  - McLaughlin D
AD  - Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell Health, 
      Glen Oaks, NY.
FAU - Olsen, Ruth
AU  - Olsen R
AD  - Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell Health, 
      Glen Oaks, NY.
FAU - Addington, Jean
AU  - Addington J
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, AB, Canada.
FAU - Bearden, Carrie E
AU  - Bearden CE
AD  - Semel Institute for Neuroscience and Human Behavior and Department of Psychology, 
      University of California, Los Angeles, Los Angeles, CA.
FAU - Cadenhead, Kristin S
AU  - Cadenhead KS
AD  - Department of Psychiatry, University of California, San Diego, La Jolla, CA.
FAU - Cannon, Tyrone D
AU  - Cannon TD
AD  - Department of Psychology, Yale University, School of Medicine, New Haven, CT.
AD  - Department of Psychiatry, Yale University, School of Medicine, New Haven, CT.
FAU - Mathalon, Daniel H
AU  - Mathalon DH
AD  - Department of Psychiatry, University of California, San Francisco, CA.
FAU - McGlashan, Thomas H
AU  - McGlashan TH
AD  - Department of Psychiatry, Yale University, School of Medicine, New Haven, CT.
FAU - Perkins, Diana O
AU  - Perkins DO
AD  - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC.
FAU - Seidman, Larry J
AU  - Seidman LJ
AD  - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical 
      Center and Massachusetts General Hospital, Boston, MA.
FAU - Tsuang, Ming T
AU  - Tsuang MT
AD  - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical 
      Center and Massachusetts General Hospital, Boston, MA.
FAU - Walker, Elaine F
AU  - Walker EF
AD  - Department of Psychology, Emory University, Atlanta, GA.
FAU - Woods, Scott W
AU  - Woods SW
AD  - Department of Psychiatry, Yale University, School of Medicine, New Haven, CT.
FAU - Cornblatt, Barbara A
AU  - Cornblatt BA
AD  - Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell Health, 
      Glen Oaks, NY.
AD  - Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, 
      Northwell Health, Manhasset, NY.
AD  - Department of Psychiatry, Zucker School of Medicine at Hofstra/Northwell, 
      Hempstead, NY.
AD  - Department of Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, 
      Hempstead, NY.
LA  - eng
GR  - U01 MH082022/MH/NIMH NIH HHS/United States
GR  - U01 MH081928/MH/NIMH NIH HHS/United States
GR  - U01 MH081902/MH/NIMH NIH HHS/United States
GR  - U01 MH081984/MH/NIMH NIH HHS/United States
GR  - P50 MH066286/MH/NIMH NIH HHS/United States
GR  - U01 MH081988/MH/NIMH NIH HHS/United States
GR  - UL1 TR001102/TR/NCATS NIH HHS/United States
GR  - P50 MH080272/MH/NIMH NIH HHS/United States
GR  - R01 MH076989/MH/NIMH NIH HHS/United States
GR  - U01 MH081857/MH/NIMH NIH HHS/United States
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
GR  - U01 MH082004/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - *Prodromal Symptoms
MH  - Psychiatric Status Rating Scales/*standards
MH  - Psychotic Disorders/*diagnosis
MH  - Reproducibility of Results
MH  - Risk
MH  - Schizophrenia/*diagnosis
MH  - Young Adult
PMC - PMC6581127
OTO - NOTNLM
OT  - Adolescent
OT  - CHR
OT  - Global Functioning: Role
OT  - Global Functioning: Social
OT  - NAPLS
OT  - Prodromal
OT  - scale validation
EDAT- 2018/10/24 06:00
MHDA- 2020/07/01 06:00
PMCR- 2020/06/18
CRDT- 2018/10/24 06:00
PHST- 2018/10/24 06:00 [pubmed]
PHST- 2020/07/01 06:00 [medline]
PHST- 2018/10/24 06:00 [entrez]
PHST- 2020/06/18 00:00 [pmc-release]
AID - 5142294 [pii]
AID - sby126 [pii]
AID - 10.1093/schbul/sby126 [doi]
PST - ppublish
SO  - Schizophr Bull. 2019 Jun 18;45(4):763-772. doi: 10.1093/schbul/sby126.