PMID- 30352219
OWN - NLM
STAT- MEDLINE
DCOM- 20200511
LR  - 20200511
IS  - 1090-2422 (Electronic)
IS  - 0014-4827 (Linking)
VI  - 374
IP  - 2
DP  - 2019 Jan 15
TI  - CSN5 promotes the invasion and metastasis of pancreatic cancer by stabilization 
      of FOXM1.
PG  - 274-281
LID - S0014-4827(18)30796-1 [pii]
LID - 10.1016/j.yexcr.2018.10.012 [doi]
AB  - COP9 signalosome subunit 5 (CSN5) has been involved in the progression of diverse 
      human cancers. MMP2 plays an important role in the metastasis of cancer cells. 
      However, the roles and relationship of in pancreatic cancer (PC) is still 
      unknown. Here, our data shown that both CSN5 and MMP2 were significantly 
      upregulated in PC compared with the corresponding adjacent tissues, where a 
      positive correlation in their expression and associated malignant characteristics 
      were found. Further, silencing of CSN5 expression markedly inhibited PC invasion 
      and metastasis in vitro and in vivo, accompanied by decreased MMP2 expression. 
      Moreover, the anti-metastasis role of CSN5 silence was reversed by MMP2 
      overexpression, whereas knockdown of MMP2 decreased PC metastasis driven by 
      upregulation of CSN5. Further investigation revealed that CSN5 regulated MMP2 
      expression via activation of FOXM1 in PC cells. Mechanistically, CSN5 directly 
      bound FOXM1 and decreased its ubiquitination to enhance the protein stability of 
      FOXM1. Taken together, the results indicate that CSN5 can contribute to PC 
      invasion and metastasis through activation of FOXM1/MMP2 axis.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Mao, Longxi
AU  - Mao L
AD  - Department of General Surgery, the Third Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Le, Shilian
AU  - Le S
AD  - Department of General Surgery, the Third Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Jin, Xin
AU  - Jin X
AD  - Department of General Surgery, the Third Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Liu, Guoliang
AU  - Liu G
AD  - Department of General Surgery, the Third Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Chen, Jun
AU  - Chen J
AD  - Department of General Surgery, the Third Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Hu, Junwen
AU  - Hu J
AD  - Department of General Surgery, the Third Affiliated Hospital of Nanchang 
      University, Nanchang, China; Department of Hepatobiliary Surgery, Tumor Hospital 
      of Guanxi Medical University, Nanning, China. Electronic address: 
      hujunwen1818@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181021
PL  - United States
TA  - Exp Cell Res
JT  - Experimental cell research
JID - 0373226
RN  - 0 (FOXM1 protein, human)
RN  - 0 (Forkhead Box Protein M1)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - EC 3.4.- (Peptide Hydrolases)
RN  - EC 3.4.-.- (COPS5 protein, human)
RN  - EC 3.4.19.12 (COP9 Signalosome Complex)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
SB  - IM
MH  - COP9 Signalosome Complex/*genetics
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Forkhead Box Protein M1/*genetics
MH  - Gene Expression Regulation, Neoplastic/genetics
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*genetics
MH  - Matrix Metalloproteinase 2/genetics
MH  - Neoplasm Invasiveness/*genetics/pathology
MH  - Neoplasm Metastasis/*genetics/pathology
MH  - PC-3 Cells
MH  - Pancreatic Neoplasms/*genetics/*pathology
MH  - Peptide Hydrolases/*genetics
MH  - Signal Transduction/genetics
MH  - Ubiquitination/genetics
MH  - Up-Regulation/genetics
OTO - NOTNLM
OT  - CSN5
OT  - FOXM1
OT  - MMP2
OT  - Metastasis
OT  - Pancreatic cancer
EDAT- 2018/10/24 06:00
MHDA- 2020/05/12 06:00
CRDT- 2018/10/24 06:00
PHST- 2018/08/26 00:00 [received]
PHST- 2018/10/14 00:00 [revised]
PHST- 2018/10/19 00:00 [accepted]
PHST- 2018/10/24 06:00 [pubmed]
PHST- 2020/05/12 06:00 [medline]
PHST- 2018/10/24 06:00 [entrez]
AID - S0014-4827(18)30796-1 [pii]
AID - 10.1016/j.yexcr.2018.10.012 [doi]
PST - ppublish
SO  - Exp Cell Res. 2019 Jan 15;374(2):274-281. doi: 10.1016/j.yexcr.2018.10.012. Epub 
      2018 Oct 21.