PMID- 30352250
OWN - NLM
STAT- MEDLINE
DCOM- 20190109
LR  - 20191210
IS  - 1638-6183 (Electronic)
IS  - 0300-9084 (Linking)
VI  - 156
DP  - 2019 Jan
TI  - Neuroprotective effects of Tat-ATOX1 protein against MPP(+)-induced SH-SY5Y cell 
      deaths and in MPTP-induced mouse model of Parkinson's disease.
PG  - 158-168
LID - S0300-9084(18)30292-X [pii]
LID - 10.1016/j.biochi.2018.10.010 [doi]
AB  - Parkinson's disease (PD), a neurodegenerative disorder, is characterized by a 
      loss of dopaminergic neurons in the substantia nigra (SN) of the brain and it is 
      well known that the pathogenesis of PD is related to a number of risk factors 
      including oxidative stress. Antioxidant 1 (ATOX1) protein plays a crucial role in 
      various diseases as an antioxidant and chaperone. In this study, we determined 
      whether Tat-ATOX1 could protect against 1-methyl-4-phenylpyridinium ion 
      (MPP(+))-induced SH-SY5Y cell death and in a 
      1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal model of PD. 
      In the MPP(+) exposed SH-SY5Y cells, Tat-ATOX1 markedly inhibited cell death and 
      toxicities. In addition, Tat-ATOX1 markedly suppressed the activation of Akt and 
      mitogen activated protein kinases (MAPKs) as well as cleavage of caspase-3 and 
      Bax expression levels. In a MPTP-induced animal model, Tat-ATOX1 transduced into 
      brain and protected dopaminergic neuronal cell loss. Taken together, Tat-ATOX1 
      inhibits dopaminergic neuronal death through the suppression of MAPKs and 
      apoptotic signal pathways. Thus, Tat-ATOX1 represents a potential therapeutic 
      protein drug candidate for PD.
CI  - Copyright (c) 2018 Elsevier B.V. and Societe Francaise de Biochimie et Biologie 
      Moleculaire (SFBBM). All rights reserved.
FAU - Eum, Won Sik
AU  - Eum WS
AD  - Department of Biomedical Science and Research Institute of Bioscience and 
      Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
FAU - Shin, Min Jea
AU  - Shin MJ
AD  - Department of Biomedical Science and Research Institute of Bioscience and 
      Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
FAU - Lee, Chi Hern
AU  - Lee CH
AD  - Department of Biomedical Science and Research Institute of Bioscience and 
      Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
FAU - Yeo, Hyeon Ji
AU  - Yeo HJ
AD  - Department of Biomedical Science and Research Institute of Bioscience and 
      Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
FAU - Yeo, Eun Ji
AU  - Yeo EJ
AD  - Department of Biomedical Science and Research Institute of Bioscience and 
      Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
FAU - Choi, Yeon Joo
AU  - Choi YJ
AD  - Department of Biomedical Science and Research Institute of Bioscience and 
      Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
FAU - Kwon, Hyun Jung
AU  - Kwon HJ
AD  - Department of Biochemistry and Molecular Biology, Research Institute of Oral 
      Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung, 
      25457, South Korea.
FAU - Kim, Duk-Soo
AU  - Kim DS
AD  - Department of Anatomy, College of Medicine, Soonchunhyang University, Cheonan-Si, 
      31538, South Korea.
FAU - Kwon, Oh Shin
AU  - Kwon OS
AD  - Department of Biochemistry, Kyungpook National University, Daegu, 41566, South 
      Korea.
FAU - Lee, Keun Wook
AU  - Lee KW
AD  - Department of Biomedical Science and Research Institute of Bioscience and 
      Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
FAU - Han, Kyu Hyung
AU  - Han KH
AD  - Department of Biomedical Science and Research Institute of Bioscience and 
      Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
FAU - Park, Jinseu
AU  - Park J
AD  - Department of Biomedical Science and Research Institute of Bioscience and 
      Biotechnology, Hallym University, Chuncheon, 24252, South Korea.
FAU - Kim, Dae Won
AU  - Kim DW
AD  - Department of Biochemistry and Molecular Biology, Research Institute of Oral 
      Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung, 
      25457, South Korea. Electronic address: kimdw@gwnu.ac.kr.
FAU - Choi, Soo Young
AU  - Choi SY
AD  - Department of Biomedical Science and Research Institute of Bioscience and 
      Biotechnology, Hallym University, Chuncheon, 24252, South Korea. Electronic 
      address: sychoi@hallym.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20181021
PL  - France
TA  - Biochimie
JT  - Biochimie
JID - 1264604
RN  - 0 (ATOX1 protein, human)
RN  - 0 (Atox1 protein, mouse)
RN  - 0 (Cation Transport Proteins)
RN  - 0 (Copper Transport Proteins)
RN  - 0 (Metallochaperones)
RN  - 0 (Molecular Chaperones)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 9P21XSP91P (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
SB  - IM
MH  - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/*pharmacology
MH  - Animals
MH  - *Cation Transport Proteins/biosynthesis/genetics
MH  - Cell Death/drug effects
MH  - Cell Line, Tumor
MH  - Copper Transport Proteins
MH  - Humans
MH  - MPTP Poisoning/metabolism/pathology/*prevention & control
MH  - Male
MH  - *Metallochaperones/biosynthesis/genetics
MH  - Mice
MH  - *Molecular Chaperones/biosynthesis/genetics
MH  - *Recombinant Fusion Proteins/biosynthesis/genetics
MH  - Transduction, Genetic
OTO - NOTNLM
OT  - Dopaminergic neuron
OT  - MAPK
OT  - Parkinson's disease
OT  - Protein therapy
OT  - Tat-ATOX1
EDAT- 2018/10/24 06:00
MHDA- 2019/01/10 06:00
CRDT- 2018/10/24 06:00
PHST- 2018/04/14 00:00 [received]
PHST- 2018/10/16 00:00 [accepted]
PHST- 2018/10/24 06:00 [pubmed]
PHST- 2019/01/10 06:00 [medline]
PHST- 2018/10/24 06:00 [entrez]
AID - S0300-9084(18)30292-X [pii]
AID - 10.1016/j.biochi.2018.10.010 [doi]
PST - ppublish
SO  - Biochimie. 2019 Jan;156:158-168. doi: 10.1016/j.biochi.2018.10.010. Epub 2018 Oct 
      21.