PMID- 30352277
OWN - NLM
STAT- MEDLINE
DCOM- 20190625
LR  - 20190625
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 80
IP  - 2
DP  - 2019 Feb
TI  - Protective association of HLA-DRB1*13:02, HLA-DRB1*04:06, and HLA-DQB1*06:04 
      alleles with cervical cancer in a Korean population.
PG  - 107-111
LID - S0198-8859(18)30582-2 [pii]
LID - 10.1016/j.humimm.2018.10.013 [doi]
AB  - Human leukocyte antigen (HLA) class II alleles have been previously associated 
      with cervical cancer. However, these associations vary widely across racial and 
      ethnic groups. Therefore, we evaluated the effect of HLA class II alleles on 
      cervical cancer in a Korean population. HLA-DRB1, HLA-DQB1, and HLA-DQA1 alleles 
      were analyzed in 457 cervical cancer patients and compared to those of 926 
      control subjects. The odds ratio (OR) of each allele between the patients and 
      controls was calculated using the logistic regression model. Patients, had 
      significantly lower frequencies of HLA-DRB1 and HLA-DQB1 alleles than control 
      subjects: HLA-DRB1*13:02:01 (4.4% vs 8.8%; OR 0.48, 95% confidence interval (CI) 
      0.27-0.84; p = 0.001), HLA-DRB1*04:06 (2.1% vs 4.7%; OR 0.44, 95% CI 0.20-0.97; 
      p = 0.033), and HLA-DQB1*06:04:01 (2.3% vs 5.0%; OR 0.46, 95% CI 0.22-0.94; 
      p = 0.021). No significant association was observed for HLA-DQA1. Protective 
      associations between HLA-DRB1*13:02, HLA-DRB1*04:06, and HLA-DQB1*06:04 alleles 
      and cervical cancer were found in the Korean population.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Shim, Hyoeun
AU  - Shim H
AD  - Department of Laboratory Medicine, National Cancer Center, Goyang, Republic of 
      Korea.
FAU - Park, Boram
AU  - Park B
AD  - Biometrics Research Branch, National Cancer Center, Goyang, Republic of Korea.
FAU - Shin, Hye-Jin
AU  - Shin HJ
AD  - Particle Therapy Research Branch, National Cancer Center, Goyang, Republic of 
      Korea.
FAU - Joo, Jungnam
AU  - Joo J
AD  - Biometrics Research Branch, National Cancer Center, Goyang, Republic of Korea.
FAU - Yoon, Kyong-Ah
AU  - Yoon KA
AD  - College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
FAU - Kim, Young Min
AU  - Kim YM
AD  - Department of Statistics, Kyungpook National University, Daegu, Republic of 
      Korea.
FAU - Hayashi, Tomonori
AU  - Hayashi T
AD  - Department of Radiobiology and Molecular Epidemiology, Radiation Effects Research 
      Foundation, Hiroshima, Japan.
FAU - Tokunaga, Katsushi
AU  - Tokunaga K
AD  - Department of Human Genetics, Graduate School of Medicine, The University of 
      Tokyo, Tokyo, Japan.
FAU - Kong, Sun-Young
AU  - Kong SY
AD  - Department of Laboratory Medicine, National Cancer Center, Goyang, Republic of 
      Korea; Translational Research Branch, National Cancer Center, Goyang, Republic of 
      Korea. Electronic address: ksy@ncc.re.kr.
FAU - Kim, Joo-Young
AU  - Kim JY
AD  - Particle Therapy Research Branch, National Cancer Center, Goyang, Republic of 
      Korea. Electronic address: jooyoungcasa@ncc.re.kr.
LA  - eng
PT  - Journal Article
DEP - 20181021
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04:06 antigen)
RN  - 0 (HLA-DRB1*13 antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - *Genotype
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Korea
MH  - Logistic Models
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Uterine Cervical Neoplasms/*genetics
EDAT- 2018/10/24 06:00
MHDA- 2019/06/27 06:00
CRDT- 2018/10/24 06:00
PHST- 2018/08/01 00:00 [received]
PHST- 2018/10/08 00:00 [revised]
PHST- 2018/10/18 00:00 [accepted]
PHST- 2018/10/24 06:00 [pubmed]
PHST- 2019/06/27 06:00 [medline]
PHST- 2018/10/24 06:00 [entrez]
AID - S0198-8859(18)30582-2 [pii]
AID - 10.1016/j.humimm.2018.10.013 [doi]
PST - ppublish
SO  - Hum Immunol. 2019 Feb;80(2):107-111. doi: 10.1016/j.humimm.2018.10.013. Epub 2018 
      Oct 21.