PMID- 30352444
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20190128
IS  - 1423-0216 (Electronic)
IS  - 1021-7401 (Linking)
VI  - 25
IP  - 3
DP  - 2018
TI  - Differential Peripheral Inflammatory Factors Associated with Cognitive Function 
      in Patients with Heart Failure.
PG  - 146-152
LID - 10.1159/000493142 [doi]
AB  - OBJECTIVE: Cognitive deficits are common in patients with heart failure (HF), and 
      can negatively affect self-care, predict rehospitalizations, and increase 
      mortality rates 5-fold. Inflammation can produce vascular pathology, reducing 
      cerebral blood flow to brain regions necessary for optimal cognitive function. 
      The purpose of the investigation was to identify a pattern of peripheral blood 
      inflammation-related biomarkers associated with cognitive impairment in patients 
      with HF. METHODS: Forty-five outpatients (median age = 67 years, SD = 9.9) were 
      recruited from University of California, San Diego (UCSD) and Veterans Affairs 
      San Diego Healthcare Systems (VASDHS), diagnosed with New York Heart Association 
      Stages I-III HF. Participants were administered the Montreal Cognitive Assessment 
      (MoCA) as a measure of global cognitive impairment, and blood was analyzed for 
      plasma biomarkers, interferon-gamma, tumor necrosis factor-alpha (TNFalpha), soluble 
      intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion 
      molecule-1 (sVCAM-1), brain-derived neurotrophic factor (BDNF), interleukin-8 
      (IL-8), matrix metallopeptidase-9 (MMP-9), IL-6, C-reactive protein (CRP), and 
      serum amyloid-A (SAA). RESULTS: Almost half the patients scored below the 
      threshold on the MoCA, indicating at least mild cognitive impairment. A factor 
      analysis produced three biomarker factors: vascular inflammatory factor-1: TNFalpha, 
      sICAM1, sVCAM1; neuroinflammatory factor-2: BDNF, MMP-9, IL-8; peripheral 
      inflammatory factor-3: IL-6, CRP, SAA. Only vascular inflammatory factor-1 was 
      significantly associated with cognitive function (MoCA) (DeltaR2 = 0.214, beta = 
      -0.468, p = 0.008). CONCLUSIONS: In this cohort with HF, vascular inflammation 
      appears related to poorer cognitive function. This could indicate targets for 
      treatment to reduce cognitive deficits in HF. However, this is a preliminary 
      study, and further research is needed.
CI  - (c) 2018 S. Karger AG, Basel.
FAU - Redwine, Laura S
AU  - Redwine LS
AD  - Department of Psychiatry, University of California San Diego, San Diego, 
      California, USAlredwine@health.usf.edu.
AD  - College of Nursing, University of South Florida, Tampa, Florida, 
      USAlredwine@health.usf.edu.
FAU - Pung, Meredith A
AU  - Pung MA
AD  - Department of Family Medicine and Public Health, University of California San 
      Diego, San Diego, California, USA.
FAU - Wilson, Kathleen
AU  - Wilson K
AD  - Department of Family Medicine and Public Health, University of California San 
      Diego, San Diego, California, USA.
FAU - Chinh, Kelly
AU  - Chinh K
AD  - Department of Psychiatry, University of California San Diego, San Diego, 
      California, USA.
FAU - Duffy, Allyson R
AU  - Duffy AR
AD  - College of Nursing, University of South Florida, Tampa, Florida, USA.
LA  - eng
GR  - R01 HL096784/HL/NHLBI NIH HHS/United States
GR  - R01HL096784/NH/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20181023
PL  - Switzerland
TA  - Neuroimmunomodulation
JT  - Neuroimmunomodulation
JID - 9422763
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Cognition/*physiology
MH  - Cognitive Dysfunction/*blood/*diagnosis
MH  - Cross-Sectional Studies
MH  - Female
MH  - Heart Failure/*blood/*diagnosis
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Male
MH  - Middle Aged
MH  - Random Allocation
OTO - NOTNLM
OT  - Heart failure
OT  - Inflammation
OT  - Mild cognitive impairment
EDAT- 2018/10/24 06:00
MHDA- 2019/01/29 06:00
CRDT- 2018/10/24 06:00
PHST- 2018/05/16 00:00 [received]
PHST- 2018/08/19 00:00 [accepted]
PHST- 2018/10/24 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
PHST- 2018/10/24 06:00 [entrez]
AID - 000493142 [pii]
AID - 10.1159/000493142 [doi]
PST - ppublish
SO  - Neuroimmunomodulation. 2018;25(3):146-152. doi: 10.1159/000493142. Epub 2018 Oct 
      23.