PMID- 30353611
OWN - NLM
STAT- MEDLINE
DCOM- 20190805
LR  - 20190805
IS  - 1432-2277 (Electronic)
IS  - 0934-0874 (Linking)
VI  - 32
IP  - 3
DP  - 2019 Mar
TI  - Assessment of simple indices based on a single fasting blood sample as a tool to 
      estimate beta-cell function after total pancreatectomy with islet 
      autotransplantation - a prospective study.
PG  - 280-290
LID - 10.1111/tri.13364 [doi]
AB  - We investigated six indices based on a single fasting blood sample for evaluation 
      of the beta-cell function after total pancreatectomy with islet 
      autotransplantation (TP-IAT). The Secretory Unit of Islet Transplant Objects 
      (SUITO), transplant estimated function (TEF), homeostasis model assessment 
      (HOMA-2B%), C-peptide/glucose ratio (CP/G), C-peptide/glucose creatinine ratio 
      (CP/GCr) and BETA-2 score were compared against a 90-min serum glucose level, 
      weighted mean C-peptide in mixed meal tolerance test (MMTT), beta score and the 
      Igls score adjusted for islet function in the setting of IAT. We analyzed values 
      from 32 MMTTs in 15 patients after TP-IAT with a follow-up of up to 3 years. Four 
      (27%) individuals had discontinued insulin completely prior to day 75, while 6 
      out of 12 patients (50%) did not require insulin support at 1-year follow-up with 
      HbA1c 6.0% (5.5-6.8). BETA-2 was the most consistent among indices strongly 
      correlating with all reference measures of beta-cell function (r = 0.62-0.68). In 
      addition, it identified insulin independence (cut-off = 16.2) and optimal/good 
      versus marginal islet function in the Igls score well, with AUROC of 0.85 and 
      0.96, respectively. Based on a single fasting blood sample, BETA-2 score has the 
      most reliable discriminant value for the assessment of graft function in patients 
      undergoing TP-IAT.
CI  - (c) 2018 Steunstichting ESOT.
FAU - Golebiewska, Justyna E
AU  - Golebiewska JE
AUID- ORCID: 0000-0001-5346-8369
AD  - Department of Surgery, University of Chicago, Chicago, IL, USA.
AD  - Department of Nephrology, Transplantology and Internal Medicine, Medical 
      University of Gdansk, Gdansk, Poland.
FAU - Bachul, Piotr J
AU  - Bachul PJ
AD  - Department of Surgery, University of Chicago, Chicago, IL, USA.
AD  - Department of Anatomy, Jagiellonian University Medical College, Krakow, Poland.
FAU - Fillman, Natalie
AU  - Fillman N
AD  - Department of Surgery, University of Chicago, Chicago, IL, USA.
FAU - Basto, Lindsay
AU  - Basto L
AD  - Department of Surgery, University of Chicago, Chicago, IL, USA.
FAU - Kijek, Mark R
AU  - Kijek MR
AD  - Department of Surgery, University of Chicago, Chicago, IL, USA.
FAU - Golab, Karolina
AU  - Golab K
AD  - Department of Surgery, University of Chicago, Chicago, IL, USA.
FAU - Wang, Ling-Jia
AU  - Wang LJ
AD  - Department of Surgery, University of Chicago, Chicago, IL, USA.
FAU - Tibudan, Martin
AU  - Tibudan M
AD  - Department of Surgery, University of Chicago, Chicago, IL, USA.
FAU - Thomas, Celeste
AU  - Thomas C
AD  - Department of Medicine, University of Chicago, Chicago, IL, USA.
FAU - Debska-Slizien, Alicja
AU  - Debska-Slizien A
AD  - Department of Nephrology, Transplantology and Internal Medicine, Medical 
      University of Gdansk, Gdansk, Poland.
FAU - Gelrud, Andres
AU  - Gelrud A
AD  - Department of Medicine, University of Chicago, Chicago, IL, USA.
FAU - Matthews, Jeffrey B
AU  - Matthews JB
AD  - Department of Surgery, University of Chicago, Chicago, IL, USA.
FAU - Millis, J Michael
AU  - Millis JM
AD  - Department of Surgery, University of Chicago, Chicago, IL, USA.
FAU - Fung, John
AU  - Fung J
AD  - Department of Surgery, University of Chicago, Chicago, IL, USA.
FAU - Witkowski, Piotr
AU  - Witkowski P
AUID- ORCID: 0000-0002-4459-6673
AD  - Department of Surgery, University of Chicago, Chicago, IL, USA.
LA  - eng
PT  - Journal Article
DEP - 20181126
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ 
      Transplantation
JID - 8908516
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
MH  - Adolescent
MH  - Adult
MH  - Blood Glucose/analysis
MH  - C-Peptide/blood
MH  - Fasting/*blood
MH  - Female
MH  - Humans
MH  - Insulin-Secreting Cells/*physiology
MH  - *Islets of Langerhans Transplantation
MH  - Male
MH  - Middle Aged
MH  - *Pancreatectomy
MH  - Prospective Studies
MH  - Transplantation, Autologous
MH  - Young Adult
OTO - NOTNLM
OT  - autologous islet transplantation
OT  - beta-cell function
OT  - surrogate indices
OT  - total pancreatectomy with islet autotransplantation
EDAT- 2018/10/26 06:00
MHDA- 2019/08/06 06:00
CRDT- 2018/10/25 06:00
PHST- 2018/08/19 00:00 [received]
PHST- 2018/10/05 00:00 [revised]
PHST- 2018/10/15 00:00 [accepted]
PHST- 2018/10/26 06:00 [pubmed]
PHST- 2019/08/06 06:00 [medline]
PHST- 2018/10/25 06:00 [entrez]
AID - 10.1111/tri.13364 [doi]
PST - ppublish
SO  - Transpl Int. 2019 Mar;32(3):280-290. doi: 10.1111/tri.13364. Epub 2018 Nov 26.