PMID- 30355275
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1607-8454 (Electronic)
IS  - 1024-5332 (Linking)
VI  - 24
IP  - 1
DP  - 2019 Dec
TI  - Relevance of antiphospholipid antibody profile in the clinical outcome of ITP: a 
      single-centre study.
PG  - 134-138
LID - 10.1080/10245332.2018.1532649 [doi]
AB  - OBJECTIVES: The relevance of detecting antibodies against anticardiolipin, 
      beta2-glycoprotein I (beta2gpI) or lupus anticoagulant (LA), collectively called 
      antiphospholipid autoantibodies (APA), in subjects with immune thrombocytopenia 
      (ITP) is still a debated issue. In particular, whether APA profile may affect the 
      clinical course of ITP is unknown. METHODS: In this study, we report our 
      experience in a cohort of ITP patients with APA with specific interest to the 
      relevance of different antiphospholipid antibody profiles in clinical outcome and 
      response to treatment. RESULTS: Thirty-seven out of 159 patients (23.2%) 
      fulfilling ITP criteria had a platelet count </=50 x 10(9)/L and tested positive at 
      APA at ITP onset. Twenty-three (62.1%) patients received at least one line of 
      treatment for ITP. Fourteen subjects (37.8%) showing triple positivity for APA 
      showed a significantly lower median platelet count compared to other APA patients 
      (p = .006). Among these ITP subjects with triple positivity, 85.7% needed a 
      treatment because of low platelet count compared to 47.8% ITP patients with 
      non-triple-positive APA (p = .0094). ITP/APA subjects who received 
      immunosuppressors had a higher rate of thrombosis (p = .024) as well as 
      thrombosis developed in subjects who were on steroid therapy at a significantly 
      higher dosage than subjects who did not develop thrombotic episodes (p < .001). 
      When considering treatment, CR and SR rate were significantly higher in 
      ITP/triple-positive patients compared to non-triple-positive subjects (p = .021 
      and p = .005). CONCLUSIONS: The profile of APA may affect the outcome of patients 
      with ITP.
FAU - Frison, Luca
AU  - Frison L
AD  - a Department of Medicine , Padova University School of Medicine , Padova , Italy.
FAU - Lombardi, Annamaria
AU  - Lombardi A
AD  - a Department of Medicine , Padova University School of Medicine , Padova , Italy.
FAU - Caputo, Ilaria
AU  - Caputo I
AD  - a Department of Medicine , Padova University School of Medicine , Padova , Italy.
FAU - Semenzato, Gianpietro
AU  - Semenzato G
AD  - a Department of Medicine , Padova University School of Medicine , Padova , Italy.
FAU - Fabris, Fabrizio
AU  - Fabris F
AD  - a Department of Medicine , Padova University School of Medicine , Padova , Italy.
FAU - Vianello, Fabrizio
AU  - Vianello F
AUID- ORCID: 0000-0002-7174-4651
AD  - a Department of Medicine , Padova University School of Medicine , Padova , Italy.
LA  - eng
PT  - Journal Article
DEP - 20181025
PL  - England
TA  - Hematology
JT  - Hematology (Amsterdam, Netherlands)
JID - 9708388
RN  - 0 (Antibodies, Antiphospholipid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Antiphospholipid/*blood
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Purpura, Thrombocytopenic, Idiopathic/*blood/complications/*mortality/therapy
MH  - Survival Rate
MH  - Thrombosis/*blood/etiology/*mortality/therapy
OTO - NOTNLM
OT  - Thrombocytopenia' immune thrombocytopenia
OT  - antiphospholipid antibodies
OT  - lupus anticoagulans
EDAT- 2018/10/26 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/10/26 06:00
PHST- 2018/10/26 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/10/26 06:00 [entrez]
AID - 10.1080/10245332.2018.1532649 [doi]
PST - ppublish
SO  - Hematology. 2019 Dec;24(1):134-138. doi: 10.1080/10245332.2018.1532649. Epub 2018 
      Oct 25.