PMID- 30355463 OWN - NLM STAT- MEDLINE DCOM- 20190530 LR - 20210109 IS - 1879-355X (Electronic) IS - 0360-3016 (Linking) VI - 102 IP - 4 DP - 2018 Nov 15 TI - Spatial Comparison of CT-Based Surrogates of Lung Ventilation With Hyperpolarized Helium-3 and Xenon-129 Gas MRI in Patients Undergoing Radiation Therapy. PG - 1276-1286 LID - S0360-3016(18)30755-7 [pii] LID - 10.1016/j.ijrobp.2018.04.077 [doi] AB - PURPOSE: To develop and apply an image acquisition and analysis strategy for spatial comparison of computed tomography (CT)-ventilation images with hyperpolarized gas magnetic resonance imaging (MRI). METHODS AND MATERIALS: Eleven lung cancer patients underwent xenon-129 ((129)Xe) and helium-3 ((3)He) ventilation MRI and coregistered proton ((1)H) anatomic MRI. Expiratory and inspiratory breath-hold CTs were used for deformable image registration and calculation of 3 CT-ventilation metrics: Hounsfield unit (CT(HU)), Jacobian (CT(Jac)), and specific gas volume change (CT(SGV)). Inspiration CT and hyperpolarized gas ventilation MRI were registered via same-breath anatomic (1)H-MRI. Voxel-wise Spearman correlation coefficients were calculated between each CT-ventilation image and its corresponding (3)He-/(129)Xe-MRI, and for the mean values in regions of interest (ROIs) ranging from fine to coarse in-plane dimensions of 5 x 5, 10 x 10, 15 x 15, and 20 x 20, located within the lungs as defined by the same-breath (1)H-MRI lung mask. Correlation of (3)He and (129)Xe-MRI was also assessed. RESULTS: Spatial correlation of CT-ventilation against (3)He/(129)Xe-MRI increased with ROI size. For example, for CT(HU), mean +/- SD Spearman coefficients were 0.37 +/- 0.19/0.33 +/- 0.17 at the voxel-level and 0.52 +/- 0.20/0.51 +/- 0.18 for 20 x 20 ROIs, respectively. Correlations were stronger for CT(HU) than for CT(Jac) or CT(SGV). Correlation of (3)He with (129)Xe-MRI was consistently higher than either gas against CT-ventilation maps over all ROIs (P < .05). No significant differences were observed between CT-ventilation versus (3)He-MRI and CT-ventilation versus (129)Xe-MRI. CONCLUSION: Comparison of ventilation-related measures from CT and registered hyperpolarized gas MRI is feasible at a voxel level using a dedicated acquisition and analysis protocol. Moderate correlation between CT-ventilation and MRI exists at a regional level. Correlation between MRI and CT is significantly less than that between (3)He and (129)Xe-MRI, suggesting that CT-ventilation surrogate measures may not be measuring lung ventilation alone. CI - Copyright (c) 2018 Elsevier Inc. All rights reserved. FAU - Tahir, Bilal A AU - Tahir BA AD - Academic Unit of Clinical Oncology, University of Sheffield, United Kingdom; POLARIS, Academic Radiology, University of Sheffield, United Kingdom. Electronic address: b.tahir@sheffield.ac.uk. FAU - Hughes, Paul J C AU - Hughes PJC AD - POLARIS, Academic Radiology, University of Sheffield, United Kingdom. FAU - Robinson, Stephen D AU - Robinson SD AD - Academic Unit of Clinical Oncology, University of Sheffield, United Kingdom; POLARIS, Academic Radiology, University of Sheffield, United Kingdom. FAU - Marshall, Helen AU - Marshall H AD - POLARIS, Academic Radiology, University of Sheffield, United Kingdom. FAU - Stewart, Neil J AU - Stewart NJ AD - POLARIS, Academic Radiology, University of Sheffield, United Kingdom. FAU - Norquay, Graham AU - Norquay G AD - POLARIS, Academic Radiology, University of Sheffield, United Kingdom. FAU - Biancardi, Alberto AU - Biancardi A AD - POLARIS, Academic Radiology, University of Sheffield, United Kingdom. FAU - Chan, Ho-Fung AU - Chan HF AD - POLARIS, Academic Radiology, University of Sheffield, United Kingdom. FAU - Collier, Guilhem J AU - Collier GJ AD - POLARIS, Academic Radiology, University of Sheffield, United Kingdom. FAU - Hart, Kerry A AU - Hart KA AD - Academic Unit of Clinical Oncology, University of Sheffield, United Kingdom. FAU - Swinscoe, James A AU - Swinscoe JA AD - Academic Unit of Clinical Oncology, University of Sheffield, United Kingdom. FAU - Hatton, Matthew Q AU - Hatton MQ AD - Academic Unit of Clinical Oncology, University of Sheffield, United Kingdom. FAU - Wild, Jame M AU - Wild JM AD - POLARIS, Academic Radiology, University of Sheffield, United Kingdom. FAU - Ireland, Rob H AU - Ireland RH AD - Academic Unit of Clinical Oncology, University of Sheffield, United Kingdom; POLARIS, Academic Radiology, University of Sheffield, United Kingdom. LA - eng GR - MR/M008894/1/MRC_/Medical Research Council/United Kingdom GR - NIHR-RP-R3-12-027/DH_/Department of Health/United Kingdom GR - SP/14/6/31350/BHF_/British Heart Foundation/United Kingdom PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180510 PL - United States TA - Int J Radiat Oncol Biol Phys JT - International journal of radiation oncology, biology, physics JID - 7603616 RN - 0 (Isotopes) RN - 0 (Xenon Isotopes) RN - 0 (Xenon-129) RN - 206GF3GB41 (Helium) RN - I83W8ELB18 (Helium-3) SB - IM MH - Adult MH - Aged MH - Female MH - *Helium MH - Humans MH - *Isotopes MH - Lung Neoplasms/diagnostic imaging/physiopathology/*radiotherapy MH - Magnetic Resonance Imaging/*methods MH - Male MH - Middle Aged MH - *Pulmonary Ventilation MH - Tomography, X-Ray Computed/*methods MH - *Xenon Isotopes EDAT- 2018/10/26 06:00 MHDA- 2019/05/31 06:00 CRDT- 2018/10/26 06:00 PHST- 2017/12/28 00:00 [received] PHST- 2018/03/21 00:00 [revised] PHST- 2018/04/26 00:00 [accepted] PHST- 2018/10/26 06:00 [entrez] PHST- 2018/10/26 06:00 [pubmed] PHST- 2019/05/31 06:00 [medline] AID - S0360-3016(18)30755-7 [pii] AID - 10.1016/j.ijrobp.2018.04.077 [doi] PST - ppublish SO - Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):1276-1286. doi: 10.1016/j.ijrobp.2018.04.077. Epub 2018 May 10.