PMID- 30355471
OWN - NLM
STAT- MEDLINE
DCOM- 20190314
LR  - 20190314
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 28
IP  - 12
DP  - 2018 Dec
TI  - Brain imaging correlates of mild cognitive impairment and early dementia in 
      patients with type 2 diabetes mellitus.
PG  - 1253-1260
LID - S0939-4753(18)30245-X [pii]
LID - 10.1016/j.numecd.2018.07.008 [doi]
AB  - BACKGROUND AND AIMS: The risk of mild cognitive impairment and dementia is 
      increased in type 2 diabetes mellitus (T2DM). We aimed to identify the 
      neuroanatomical correlates of mild cognitive impairment (MCI) and early dementia 
      in patients with T2DM, using advanced multimodal MRI. METHODS AND RESULTS: 
      Twenty-five patients (>/=70 years) with T2DM and MCI (n = 22) or early dementia 
      (n = 3) were included. The reference group consisted of 23 patients with T2DM 
      with intact cognition. All patients underwent a 3 T MRI. Brain volumes and white 
      matter hyperintensity volumes were obtained with automated segmentation methods. 
      White matter connectivity was assessed with diffusion tensor imaging and fiber 
      tractography. Infarcts and microbleeds were rated visually. Compared to patients 
      without cognitive impairment, those with impairment had a lower grey matter 
      volume (effect size: -0.58, p=0.042), especially in the right temporal lobe and 
      subcortical brain regions (effect sizes: -0.45 to -0.91, false discovery rate 
      corrected p < 0.05). White matter volume (effect size: -0.47, p = 0.11) and white 
      matter connectivity (effect size: 0.55, p = 0.054) were also reduced in patients 
      with versus without cognitive impairment, albeit not statistically significant. 
      White matter hyperintensity volumes and occurrence of other vascular lesions did 
      not differ between the two patient groups. CONCLUSION: In patients with T2DM, 
      grey matter atrophy rather than vascular brain injury appears to be the primary 
      imaging correlate of MCI and early dementia.
CI  - Copyright (c) 2018 The Italian Society of Diabetology, the Italian Society for the 
      Study of Atherosclerosis, the Italian Society of Human Nutrition, and the 
      Department of Clinical Medicine and Surgery, Federico II University. Published by 
      Elsevier B.V. All rights reserved.
FAU - Groeneveld, O
AU  - Groeneveld O
AD  - Brain Center Rudolf Magnus, Department of Neurology, University Medical Center 
      Utrecht, University Utrecht, Utrecht, The Netherlands. Electronic address: 
      o.n.groeneveld@umcutrecht.nl.
FAU - Reijmer, Y
AU  - Reijmer Y
AD  - Brain Center Rudolf Magnus, Department of Neurology, University Medical Center 
      Utrecht, University Utrecht, Utrecht, The Netherlands.
FAU - Heinen, R
AU  - Heinen R
AD  - Brain Center Rudolf Magnus, Department of Neurology, University Medical Center 
      Utrecht, University Utrecht, Utrecht, The Netherlands.
FAU - Kuijf, H
AU  - Kuijf H
AD  - Image Sciences Institute, University Medical Center Utrecht, University Utrecht, 
      Utrecht, The Netherlands.
FAU - Koekkoek, P
AU  - Koekkoek P
AD  - Julius Center for Health Sciences and Primary Care, University Medical Center 
      Utrecht, University Utrecht, Utrecht, The Netherlands.
FAU - Janssen, J
AU  - Janssen J
AD  - Julius Center for Health Sciences and Primary Care, University Medical Center 
      Utrecht, University Utrecht, Utrecht, The Netherlands.
FAU - Rutten, G
AU  - Rutten G
AD  - Julius Center for Health Sciences and Primary Care, University Medical Center 
      Utrecht, University Utrecht, Utrecht, The Netherlands.
FAU - Kappelle, L
AU  - Kappelle L
AD  - Brain Center Rudolf Magnus, Department of Neurology, University Medical Center 
      Utrecht, University Utrecht, Utrecht, The Netherlands.
FAU - Biessels, G
AU  - Biessels G
AD  - Brain Center Rudolf Magnus, Department of Neurology, University Medical Center 
      Utrecht, University Utrecht, Utrecht, The Netherlands.
CN  - COG-ID study group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180802
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrophy
MH  - Brain/*diagnostic imaging/pathology
MH  - Case-Control Studies
MH  - *Cognition
MH  - Cognitive Dysfunction/*diagnostic imaging/etiology/pathology/psychology
MH  - Cross-Sectional Studies
MH  - Dementia/*diagnostic imaging/etiology/pathology/psychology
MH  - Diabetes Mellitus, Type 2/*complications/diagnosis
MH  - *Diffusion Magnetic Resonance Imaging
MH  - Diffusion Tensor Imaging
MH  - Early Diagnosis
MH  - Female
MH  - Gray Matter/diagnostic imaging/pathology
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
MH  - Predictive Value of Tests
MH  - Risk Factors
OTO - NOTNLM
OT  - Cognitive dysfunction
OT  - Dementia
OT  - Diffusion tensor imaging
OT  - MRI
OT  - Mild cognitive impairment
OT  - Type 2 diabetes mellitus
EDAT- 2018/10/26 06:00
MHDA- 2019/03/15 06:00
CRDT- 2018/10/26 06:00
PHST- 2018/05/17 00:00 [received]
PHST- 2018/07/07 00:00 [revised]
PHST- 2018/07/24 00:00 [accepted]
PHST- 2018/10/26 06:00 [pubmed]
PHST- 2019/03/15 06:00 [medline]
PHST- 2018/10/26 06:00 [entrez]
AID - S0939-4753(18)30245-X [pii]
AID - 10.1016/j.numecd.2018.07.008 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2018 Dec;28(12):1253-1260. doi: 
      10.1016/j.numecd.2018.07.008. Epub 2018 Aug 2.