PMID- 30356585
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2213-2961 (Electronic)
IS  - 2095-2546 (Print)
IS  - 2213-2961 (Linking)
VI  - 6
IP  - 2
DP  - 2017 Jun
TI  - Obesity promotes oxidative stress and exacerbates blood-brain barrier disruption 
      after high-intensity exercise.
PG  - 225-230
LID - 10.1016/j.jshs.2016.06.005 [doi]
AB  - PURPOSE: The purpose of this study was to investigate the effects of obesity and 
      high-intensity acute exercise on oxidant-antioxidant status, neurotrophic factor 
      expression, and blood-brain barrier (BBB) disruption. METHODS: Twenty-four 
      healthy, untrained men (12 non-obese (mean 14.9% body fat) and 12 obese subjects 
      (mean 29.8% body fat)) performed 20 min of continuous submaximal aerobic exercise 
      at 85% maximal oxygen consumption. Blood sampling was performed to examine the 
      oxidant-antioxidant status (reactive oxygen species (ROS) and superoxide 
      dismutase (SOD)), neurotrophic factors (brain-derived neurotrophic factor (BDNF) 
      and nerve growth factor (NGF)), and BBB disruption (S100beta and neuron-specific 
      enolase) before and after acute exercise. RESULTS: The obese group showed 
      significantly higher pre-exercise serum ROS levels and significantly lower 
      pre-exercise serum SOD levels than the non-obese group (p < 0.05). Serum ROS, 
      SOD, BDNF, NGF, and S100beta levels were significantly increased post-exercise 
      compared with pre-exercise levels in both the non-obese and the obese groups 
      (p < 0.05). The obese group showed significantly higher serum ROS, BDNF, NGF, and 
      S100beta levels post-exercise compared to the non-obese group (p < 0.05). 
      CONCLUSION: Our study suggests that episodic vigorous exercise can increase 
      oxidative stress and blood neurotrophic factor levels and induce disruption of 
      the BBB. Moreover, high levels of neurotrophic factor in the blood after exercise 
      in the obese group may be due to BBB disruption, and it is assumed that oxidative 
      stress was the main cause of this BBB disruption.
FAU - Roh, Hee-Tae
AU  - Roh HT
AD  - Department of Physical Education, Dong-A University, Busan 604-714, Republic of 
      Korea.
FAU - Cho, Su-Youn
AU  - Cho SY
AD  - School of Taekwondo, College of Creative Human Resources, Youngsan University, 
      Yangsan-si 626-790, Republic of Korea.
FAU - So, Wi-Young
AU  - So WY
AD  - Sports and Health Care Major, College of Humanities and Arts, Korea National 
      University of Transportation, Chungju-si 380-702, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20160627
PL  - China
TA  - J Sport Health Sci
JT  - Journal of sport and health science
JID - 101606001
PMC - PMC6188985
OTO - NOTNLM
OT  - Antioxidant enzyme
OT  - Blood-brain barrier
OT  - Exercise
OT  - Neurotrophic factor
OT  - Obesity
OT  - Oxidative stress
EDAT- 2017/06/01 00:00
MHDA- 2017/06/01 00:01
PMCR- 2016/06/27
CRDT- 2018/10/26 06:00
PHST- 2015/11/06 00:00 [received]
PHST- 2016/03/25 00:00 [revised]
PHST- 2016/04/06 00:00 [accepted]
PHST- 2018/10/26 06:00 [entrez]
PHST- 2017/06/01 00:00 [pubmed]
PHST- 2017/06/01 00:01 [medline]
PHST- 2016/06/27 00:00 [pmc-release]
AID - S2095-2546(16)30044-8 [pii]
AID - 10.1016/j.jshs.2016.06.005 [doi]
PST - ppublish
SO  - J Sport Health Sci. 2017 Jun;6(2):225-230. doi: 10.1016/j.jshs.2016.06.005. Epub 
      2016 Jun 27.