PMID- 30356625
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2213-2961 (Electronic)
IS  - 2095-2546 (Print)
IS  - 2213-2961 (Linking)
VI  - 6
IP  - 4
DP  - 2017 Dec
TI  - The effects of aerobic exercise training on oxidant-antioxidant balance, 
      neurotrophic factor levels, and blood-brain barrier function in obese and 
      non-obese men.
PG  - 447-453
LID - 10.1016/j.jshs.2016.07.006 [doi]
AB  - PURPOSE: The purpose of this study was to investigate the effects of obesity and 
      aerobic exercise training on oxidant-antioxidant balance, neurotrophic factor 
      levels, and blood-brain barrier (BBB) function. METHODS: Ten non-obese healthy 
      men (body mass index < 25 kg/m(2)) and 10 obese men (body mass 
      index >/= 25 kg/m(2)) were included in the study. Both groups performed treadmill 
      exercise for 40 min 3 times weekly for 8 weeks at 70% heart rate reserve. Blood 
      samples were collected to examine oxidant-antioxidant balance (reactive oxygen 
      species (ROS) and superoxide dismutase (SOD) activity levels), neurotrophic 
      factors (brain-derived neurotrophic factor (BDNF), nerve growth factor, and glial 
      cell line-derived neurotrophic factor levels), and BBB function (S100beta and 
      neuron-specific enolase (NSE) levels) before and after exercise training. 
      RESULTS: The obese group showed significantly greater changes than the non-obese 
      group in serum ROS (-0.46 +/- 0.31 mmol/L vs. -0.10 +/- 0.17 mmol/L, p = 0.005), 
      serum S100beta levels (-8.50 +/- 5.92 ng/L vs. -0.78 +/- 5.45 ng/L, p = 0.007), and 
      serum NSE levels (-0.89 +/- 0.54 microg/L vs. -0.01 +/- 0.74 microg/L, p = 0.007) after 
      training. At baseline, the obese group showed significantly higher serum ROS and 
      S100beta levels and significantly lower serum SOD activity and BDNF levels than the 
      non-obese group (p < 0.05). The obese group showed significantly lower serum ROS, 
      S100beta, and NSE levels and significantly higher serum SOD activity and BDNF levels 
      after training compared with baseline (p < 0.05). CONCLUSION: These results 
      suggest that obesity can reduce serum neurotrophic factor levels and can induce 
      BBB dysfunction. On the other hand, aerobic exercise can improve an 
      oxidant-antioxidant imbalance in obese subjects and limit BBB dysfunction.
FAU - Roh, Hee-Tae
AU  - Roh HT
AD  - Department of Physical Education, College of Arts and Physical Education, Dong-A 
      University, Busan 604-714, Republic of Korea.
FAU - So, Wi-Young
AU  - So WY
AD  - Sports and Health Care Major, College of Humanities and Arts, Korea National 
      University of Transportation, Chungju-si 380-702, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20160718
PL  - China
TA  - J Sport Health Sci
JT  - Journal of sport and health science
JID - 101606001
PMC - PMC6189263
OTO - NOTNLM
OT  - Blood-brain barrier
OT  - Exercise training
OT  - Neurotrophic factor
OT  - Obesity
OT  - Oxidative stress
OT  - Redox balance
EDAT- 2018/10/26 06:00
MHDA- 2018/10/26 06:01
PMCR- 2016/07/18
CRDT- 2018/10/26 06:00
PHST- 2015/12/13 00:00 [received]
PHST- 2016/04/02 00:00 [revised]
PHST- 2016/04/18 00:00 [accepted]
PHST- 2018/10/26 06:00 [entrez]
PHST- 2018/10/26 06:00 [pubmed]
PHST- 2018/10/26 06:01 [medline]
PHST- 2016/07/18 00:00 [pmc-release]
AID - S2095-2546(16)30056-4 [pii]
AID - 10.1016/j.jshs.2016.07.006 [doi]
PST - ppublish
SO  - J Sport Health Sci. 2017 Dec;6(4):447-453. doi: 10.1016/j.jshs.2016.07.006. Epub 
      2016 Jul 18.