PMID- 30356686
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 9
DP  - 2018
TI  - Cross-Dysregulation of O-GlcNAcylation and PI3K/AKT/mTOR Axis in Human Chronic 
      Diseases.
PG  - 602
LID - 10.3389/fendo.2018.00602 [doi]
LID - 602
AB  - The hexosamine biosynthetic pathway (HBP) and the phosphatidylinositol 3-kinase 
      (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway are considered 
      as nutrient sensors that regulate several essential biological processes. The 
      hexosamine biosynthetic pathway produces uridine diphosphate N-acetylglucosamine 
      (UDP-GlcNAc), the substrate for O-GlcNAc transferase (OGT), the enzyme that 
      O-GlcNAcylates proteins on serine (Ser) and threonine (Thr) residues. O-linked 
      beta-N-acetylglucosaminylation (O-GlcNAcylation) and phosphorylation are highly 
      dynamic post-translational modifications occurring at the same or adjacent sites 
      that regulate folding, stability, subcellular localization, partner interaction, 
      or activity of target proteins. Here we review recent evidence of a 
      cross-regulation of PI3K/AKT/mTOR signaling pathway and protein O-GlcNAcylation. 
      Furthermore, we discuss their co-dysregulation in pathological conditions, e.g., 
      cancer, type-2 diabetes (T2D), and cardiovascular, and neurodegenerative 
      diseases.
FAU - Very, Ninon
AU  - Very N
AD  - Universite Lille, CNRS, UMR 8576-UGSF-Unite de Glycobiologie Structurale et 
      Fonctionnelle, Lille, France.
FAU - Vercoutter-Edouart, Anne-Sophie
AU  - Vercoutter-Edouart AS
AD  - Universite Lille, CNRS, UMR 8576-UGSF-Unite de Glycobiologie Structurale et 
      Fonctionnelle, Lille, France.
FAU - Lefebvre, Tony
AU  - Lefebvre T
AD  - Universite Lille, CNRS, UMR 8576-UGSF-Unite de Glycobiologie Structurale et 
      Fonctionnelle, Lille, France.
FAU - Hardiville, Stephan
AU  - Hardiville S
AD  - Universite Lille, CNRS, UMR 8576-UGSF-Unite de Glycobiologie Structurale et 
      Fonctionnelle, Lille, France.
FAU - El Yazidi-Belkoura, Ikram
AU  - El Yazidi-Belkoura I
AD  - Universite Lille, CNRS, UMR 8576-UGSF-Unite de Glycobiologie Structurale et 
      Fonctionnelle, Lille, France.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181009
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC6189293
OTO - NOTNLM
OT  - O-GlcNAcylation
OT  - PI3K/AKT/mTOR
OT  - cancer
OT  - cardiovascular
OT  - diabetes
OT  - neurodegenerative diseases
EDAT- 2018/10/26 06:00
MHDA- 2018/10/26 06:01
PMCR- 2018/01/01
CRDT- 2018/10/26 06:00
PHST- 2018/07/20 00:00 [received]
PHST- 2018/09/21 00:00 [accepted]
PHST- 2018/10/26 06:00 [entrez]
PHST- 2018/10/26 06:00 [pubmed]
PHST- 2018/10/26 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2018.00602 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2018 Oct 9;9:602. doi: 10.3389/fendo.2018.00602. 
      eCollection 2018.