PMID- 30356904
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240402
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 12
DP  - 2018
TI  - Nesting Environment Provides Sex-Specific Neuroprotection in a Rat Model of 
      Neonatal Hypoxic-Ischemic Injury.
PG  - 221
LID - 10.3389/fnbeh.2018.00221 [doi]
LID - 221
AB  - Hypoxic-ischemic (HI) encephalopathy is a devastating injury that occurs when the 
      fetal brain is deprived of oxygen and blood to a degree that may lead to 
      neurological damage, seizing and cerebral palsy. In rodents, early environmental 
      enrichment that promotes maternal care-taking behavior (mCTB) can improve 
      neurobehavioral outcomes and protect against neurological decline. We 
      hypothesized that an enhanced nesting environment would improve mCTB as measured 
      by pup weight gain, and support greater HI recovery in developing rats. Pregnant 
      dams (E15-16) were introduced to either control Standard Facility (SF) housing or 
      closed nestbox (CN) conditions and maintained in larger cages through pup 
      weaning. On postnatal day (PND) 7, male and female Long-Evans rat pups (N = 73) 
      were randomly sorted into one of two surgical conditions: control and HI. HI pups 
      received isoflurane anesthesia and right carotid artery ligation, a 2-h rest 
      followed by 90 min exposure to a moist hypoxic (92% N, 8% O2) chamber. Pups (PND 
      8) were weighed daily, and tested on the Morris Water Maze (MWM) task (PND 
      35-50). Results demonstrate significant differences afforded to male and female 
      pups based on weight measure, where CN-rearing modifies pre-weaning adolescent 
      weights in females and increases post-weaning weights in males and females by an 
      average of 10 g. Following successful MWM training and acquisition (PND 35-37), 
      both male and female CN-raised animals demonstrated faster latency to find the 
      hidden platform (HP) during HP trials (PND 38-42) and appeared to freely explore 
      the MWM pool during an additional probe trial (PND 43). Moreover, after sacrifice 
      (PND 60), CN rearing created sex-specific alterations in brain-derived 
      neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF) 
      immunopositive cell staining of the dorsomedial striatum and CA1 of the 
      hippocampus. CN-rearing afforded HI males higher BDNF levels in the striatum and 
      produced greater GDNF levels in the hippocampus of HI-injured females. These 
      results suggest that early life environmental enrichment positively modifies 
      nesting environment, increases weight gain, as well as spatial learning and 
      memory in a sex-specific directionality. Our findings also implicate correlative 
      changes in corticolimbic neurotrophin protein levels in the CN-reared animals 
      that may contribute to these benefits.
FAU - Mason, Briana
AU  - Mason B
AD  - Developmental and Brain Sciences, Department of Psychology, University of 
      Massachusetts Boston, Boston, MA, United States.
FAU - Rollins, L G
AU  - Rollins LG
AD  - Clinical Psychology Program, Department of Psychology, University of 
      Massachusetts Boston, Boston, MA, United States.
AD  - Warren Alpert Medical School, Department of Psychiatry, Brown University, 
      Providence, RI, United States.
FAU - Asumadu, Evans
AU  - Asumadu E
AD  - Developmental and Brain Sciences, Department of Psychology, University of 
      Massachusetts Boston, Boston, MA, United States.
FAU - Cange, Christina
AU  - Cange C
AD  - Developmental and Brain Sciences, Department of Psychology, University of 
      Massachusetts Boston, Boston, MA, United States.
FAU - Walton, Najah
AU  - Walton N
AD  - Developmental and Brain Sciences, Department of Psychology, University of 
      Massachusetts Boston, Boston, MA, United States.
FAU - Donaldson, S Tiffany
AU  - Donaldson ST
AD  - Developmental and Brain Sciences, Department of Psychology, University of 
      Massachusetts Boston, Boston, MA, United States.
LA  - eng
GR  - T32 MH078788/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20181002
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC6190890
OTO - NOTNLM
OT  - Long Evans rats
OT  - Morris water maze
OT  - Rice-Vanucci P7 HI model
OT  - environmental enrichment
OT  - hippocampus
OT  - neonatal hypoxic ischemic injury
OT  - neurogenesis
EDAT- 2018/10/26 06:00
MHDA- 2018/10/26 06:01
PMCR- 2018/01/01
CRDT- 2018/10/26 06:00
PHST- 2018/05/23 00:00 [received]
PHST- 2018/09/03 00:00 [accepted]
PHST- 2018/10/26 06:00 [entrez]
PHST- 2018/10/26 06:00 [pubmed]
PHST- 2018/10/26 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2018.00221 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2018 Oct 2;12:221. doi: 10.3389/fnbeh.2018.00221. 
      eCollection 2018.