PMID- 30357416 OWN - NLM STAT- MEDLINE DCOM- 20200910 LR - 20200910 IS - 1460-2385 (Electronic) IS - 0931-0509 (Linking) VI - 35 IP - 2 DP - 2020 Feb 1 TI - Associations of urinary epidermal growth factor and monocyte chemotactic protein-1 with kidney involvement in patients with diabetic kidney disease. PG - 291-297 LID - 10.1093/ndt/gfy314 [doi] AB - BACKGROUND: In diabetic kidney disease (DKD), it is important to find biomarkers for predicting initiation and progression of the disease. Besides glomerular damage, kidney tubular injury and inflammation are also involved in the development of DKD. The current study investigated the associations of urinary epidermal growth factor (uEGF), monocyte chemotactic protein-1 (MCP-1) and the uEGF:MCP-1 ratio with kidney involvement in patients at early and advanced stages of DKD. METHODS: The concentration of uEGF and uMCP-1 was measured in two Chinese population-based studies. The associations of uEGF, uMCP-1 and uEGF/MCP-1 with occurrence of DKD were studied in a cross-sectional study (n = 1811) of early stage DKD. Associations of baseline uEGF, uMCP-1 and uEGF/MCP-1 with kidney outcome were assessed in a longitudinal cohort (n = 208) of advanced-stage DKD. RESULTS: In both studies, positive correlations were found between uEGF/urine creatinine (Cr) and estimated glomerular filtration rate (eGFR) at sampling and between uMCP-1/Cr and urinary albumin:creatinine ratio (uACR). In the cross-sectional study, uEGF/Cr and uEGF/MCP-1 were negatively associated with the occurrence of DKD odds ratio (OR) 0.65 [95% confidence interval (CI) 0.54-0.79], P < 0.001; 0.82 (0.71-0.94), P = 0.005, respectively. In the longitudinal cohort, the uEGF:MCP-1 ratio correlated more closely with the percentage change of eGFR slope (r = 0.33, P < 0.001) as compared with uEGF/Cr or uMCP-1/Cr alone. The composite endpoint was defined as end-stage renal disease or 30% reduction of eGFR. These three markers were independently associated with composite endpoint after adjusting for potential confounders [hazard ratio 0.76 (0.59-1.00), P = 0.047 for uEGF/Cr; 1.18 (1.02-1.38), P = 0.028 for uMCP-1/Cr; 0.79 (0.68-0.91), P = 0.001 for uEGF/MCP-1]. CONCLUSION: In Chinese patients, urinary EGF/MCP-1 was negatively associated with the occurrence of DKD. Moreover, uEGF/MCP-1 had a better ability to predict the composite endpoint and correlated more closely with kidney function decline in advanced DKD as compared with uEGF/Cr or uMCP-1/Cr alone. CI - (c) The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. FAU - Wu, Liang AU - Wu L AD - Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China. AD - Institute of Nephrology, Peking University, Beijing, China. AD - Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China. AD - Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China. FAU - Li, Xiao-Qian AU - Li XQ AD - Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China. AD - Institute of Nephrology, Peking University, Beijing, China. AD - Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China. AD - Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China. FAU - Chang, Dong-Yuan AU - Chang DY AD - Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China. AD - Institute of Nephrology, Peking University, Beijing, China. AD - Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China. AD - Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China. FAU - Zhang, Huifen AU - Zhang H AD - Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan, China. FAU - Li, Jun-Juan AU - Li JJ AD - Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan, China. FAU - Wu, Shou-Ling AU - Wu SL AD - Kailuan General Hospital Affiliated to North China University of Science and Technology, Tangshan, China. FAU - Zhang, Lu-Xia AU - Zhang LX AD - Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China. AD - Institute of Nephrology, Peking University, Beijing, China. AD - Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China. AD - Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China. AD - Center for Data Science in Health and Medicine, Peking University, Beijing, China. FAU - Chen, Min AU - Chen M AD - Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China. AD - Institute of Nephrology, Peking University, Beijing, China. AD - Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China. AD - Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China. FAU - Zhao, Ming-Hui AU - Zhao MH AD - Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China. AD - Institute of Nephrology, Peking University, Beijing, China. AD - Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China. AD - Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Nephrol Dial Transplant JT - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JID - 8706402 RN - 0 (Biomarkers) RN - 0 (CCL2 protein, human) RN - 0 (Chemokine CCL2) RN - 62229-50-9 (Epidermal Growth Factor) RN - AYI8EX34EU (Creatinine) SB - IM MH - Biomarkers/*urine MH - Chemokine CCL2/*urine MH - Creatinine/urine MH - Cross-Sectional Studies MH - Diabetic Nephropathies/*complications MH - Disease Progression MH - Epidermal Growth Factor/*urine MH - Female MH - Glomerular Filtration Rate MH - Humans MH - Kidney/physiopathology MH - Kidney Failure, Chronic/*diagnosis/etiology/urine MH - Kidney Function Tests MH - Male MH - Middle Aged OTO - NOTNLM OT - diabetic kidney disease OT - epidermal growth factor OT - monocyte chemotactic pepetide-1 EDAT- 2018/10/26 06:00 MHDA- 2020/09/12 06:00 CRDT- 2018/10/26 06:00 PHST- 2018/07/01 00:00 [received] PHST- 2018/09/05 00:00 [accepted] PHST- 2018/10/26 06:00 [pubmed] PHST- 2020/09/12 06:00 [medline] PHST- 2018/10/26 06:00 [entrez] AID - 5143996 [pii] AID - 10.1093/ndt/gfy314 [doi] PST - ppublish SO - Nephrol Dial Transplant. 2020 Feb 1;35(2):291-297. doi: 10.1093/ndt/gfy314.