PMID- 30357547 OWN - NLM STAT- MEDLINE DCOM- 20190423 LR - 20200225 IS - 1875-8312 (Electronic) IS - 1569-5794 (Linking) VI - 35 IP - 3 DP - 2019 Mar TI - Native T1 mapping to detect extent of acute and chronic myocardial infarction: comparison with late gadolinium enhancement technique. PG - 517-527 LID - 10.1007/s10554-018-1467-1 [doi] AB - Investigate whether native-T1 mapping can assess the transmural extent of myocardial infarction (TEI) thereby differentiating viable from non-viable myocardium without the use of gadolinium-contrast in both acute and chronic myocardial infarction (aMI and cMI). Sixty patients (30 cMI > 1 year and 30 aMI day 2 STEMI) and 20 healthy-controls underwent 1.5 T CMR to assess left ventricular function (cine), native-T1 mapping (MOLLI sequence 5(3)3, motion-corrected) and the presence and TEI from late gadolinium enhancement (LGE) images. Segments with TEI > 75% was considered non-viable. Gold-standard LGE-TEI was compared with corresponding segmental native-T1. Segmental native-T1 correlated significantly with TEI (R = 0.74, p < 0.001 in cMI and R = 0.57, p < 0.001 in aMI). Native-T1 differentiated segments with no LGE (1031 +/- 31 ms), LGE positive but viable (1103 +/- 57 ms) and LGE positive but non-viable (1206 +/- 118 ms) in cMI (p < 0.01). It also differentiated segments with no LGE (1054 +/- 65 m), LGE positive but viable (1135 +/- 73 ms) and LGE positive but non-viable (1168 +/- 71 ms) in aMI (p < 0.01). ROC analysis demonstrated excellent accuracy of native-T1 mapping compared to LGE-TEI (AUC - 0.88, p < 0.001 in cMI, vs AUC - 0.83, p < 0.001 in aMI). Native-T1 performed better in cMI than aMI (p < 0.01). In cMI a segmental T1 threshold of 1085 ms differentiated viable from non-viable segments with a sensitivity 88% and specificity of 88% whereas a T1 of 1110 ms differentiated viable from nonviable with 79% sensitivity and 79% specificity in aMI. Native-T1 mapping correlates significantly with TEI thereby differentiating between normal, viable, and non-viable myocardium with distinctive T1 profiles in aMI and cMI. Native T1-mapping to detect MI performed better in cMI compared to aMI due to absence of myocardial oedema. Native-T1 mapping holds promise for viability assessment without the need for gadolinium-contrast agent. FAU - Dastidar, Amardeep Ghosh AU - Dastidar AG AD - Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, Bristol, BS2 8HW, UK. AD - Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. FAU - Harries, Iwan AU - Harries I AD - Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, Bristol, BS2 8HW, UK. AD - Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. FAU - Pontecorboli, Giulia AU - Pontecorboli G AD - Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, Bristol, BS2 8HW, UK. FAU - Bruno, Vito D AU - Bruno VD AD - Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, Bristol, BS2 8HW, UK. AD - Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. FAU - De Garate, Estefania AU - De Garate E AD - Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, Bristol, BS2 8HW, UK. AD - NIHR Bristol Cardiovascular Biomedical Research Centre, Bristol Heart Institute, University Hospitals Bristol and University of Bristol, Bristol, UK. AD - Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. FAU - Moret, Charlie AU - Moret C AD - Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, Bristol, BS2 8HW, UK. FAU - Baritussio, Anna AU - Baritussio A AD - Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, Bristol, BS2 8HW, UK. FAU - Johnson, Thomas W AU - Johnson TW AD - Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, Bristol, BS2 8HW, UK. FAU - McAlindon, Elisa AU - McAlindon E AD - Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, Bristol, BS2 8HW, UK. AD - NIHR Bristol Cardiovascular Biomedical Research Centre, Bristol Heart Institute, University Hospitals Bristol and University of Bristol, Bristol, UK. FAU - Bucciarelli-Ducci, Chiara AU - Bucciarelli-Ducci C AD - Bristol Heart Institute, University Hospitals Bristol NHS Trust, Upper Maudlin Street, Bristol, BS2 8HW, UK. c.bucciarelli-ducci@bristol.ac.uk. AD - NIHR Bristol Cardiovascular Biomedical Research Centre, Bristol Heart Institute, University Hospitals Bristol and University of Bristol, Bristol, UK. c.bucciarelli-ducci@bristol.ac.uk. AD - Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. c.bucciarelli-ducci@bristol.ac.uk. LA - eng PT - Comparative Study PT - Journal Article DEP - 20181024 PL - United States TA - Int J Cardiovasc Imaging JT - The international journal of cardiovascular imaging JID - 100969716 RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 1BJ477IO2L (gadobutrol) SB - IM MH - Acute Disease MH - Adult MH - Aged MH - Case-Control Studies MH - Chronic Disease MH - Contrast Media/*administration & dosage MH - Female MH - Humans MH - Image Interpretation, Computer-Assisted/*methods MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Myocardial Infarction/*diagnostic imaging/pathology/physiopathology MH - Myocardium/*pathology MH - Observer Variation MH - Organometallic Compounds/*administration & dosage MH - Predictive Value of Tests MH - Reproducibility of Results MH - Tissue Survival MH - *Ventricular Function, Left OTO - NOTNLM OT - Cardiovascular magnetic resonance OT - Myocardial infarction OT - T1 mapping OT - Viability EDAT- 2018/10/26 06:00 MHDA- 2019/04/24 06:00 CRDT- 2018/10/26 06:00 PHST- 2018/07/07 00:00 [received] PHST- 2018/10/10 00:00 [accepted] PHST- 2018/10/26 06:00 [pubmed] PHST- 2019/04/24 06:00 [medline] PHST- 2018/10/26 06:00 [entrez] AID - 10.1007/s10554-018-1467-1 [pii] AID - 10.1007/s10554-018-1467-1 [doi] PST - ppublish SO - Int J Cardiovasc Imaging. 2019 Mar;35(3):517-527. doi: 10.1007/s10554-018-1467-1. Epub 2018 Oct 24.