PMID- 30357729
OWN - NLM
STAT- MEDLINE
DCOM- 20190718
LR  - 20190718
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1071
DP  - 2018
TI  - What Is the Point of the Peak? Assessing Steady-State Respiratory Chemoreflex 
      Drive in High Altitude Field Studies.
PG  - 13-23
LID - 10.1007/978-3-319-91137-3_2 [doi]
AB  - Measurements of central and peripheral respiratory chemoreflexes are important in 
      the context of high altitude as indices of ventilatory acclimatization. However, 
      respiratory chemoreflex tests have many caveats in the field, including 
      considerations of safety, portability and consistency. This overview will (a) 
      outline commonly utilized tests of the hypoxic ventilatory response (HVR) in 
      humans, (b) outline the caveats associated with a variety of peak response HVR 
      tests in the laboratory and in high altitude fieldwork contexts, and (c) advance 
      a novel index of steady-state chemoreflex drive (SS-CD) that addresses the many 
      limitations of other chemoreflex tests. The SS-CD takes into account the 
      contribution of central and peripheral respiratory chemoreceptors, and eliminates 
      the need for complex equipment and transient respiratory gas perturbation tests. 
      To quantify the SS-CD, steady-state measurements of the pressure of end-tidal 
      (P(ET))CO(2) (Torr) and peripheral oxygen saturation (SpO(2); %) are used to 
      quantify a stimulus index (SI; P(ET)CO(2)/SpO(2)). The SS-CD is then calculated 
      by indexing resting ventilation (L/min) against the SI. SS-CD data are 
      subsequently reported from 13 participants during incremental ascent to high 
      altitude (5160 m) in the Nepal Himalaya. The mean SS-CD magnitude increased 
      approximately 96% over 10 days of incremental exposure to hypobaric hypoxia, 
      suggesting that the SS-CD tracks ventilatory acclimatization. This novel SS-CD 
      may have future utility in fieldwork studies assessing ventilatory 
      acclimatization during incremental or prolonged stays at altitude, and may 
      replace the use of complex and potentially confounded transient peak response 
      tests of the HVR in humans.
FAU - Bruce, Christina D
AU  - Bruce CD
AD  - Department of Biology, Faculty of Science and Technology, Mount Royal University, 
      Calgary, AB, Canada.
FAU - Saran, Gary
AU  - Saran G
AD  - Department of Biology, Faculty of Science and Technology, Mount Royal University, 
      Calgary, AB, Canada.
FAU - Pfoh, Jamie R
AU  - Pfoh JR
AD  - Department of Biology, Faculty of Science and Technology, Mount Royal University, 
      Calgary, AB, Canada.
FAU - Leacy, Jack K
AU  - Leacy JK
AD  - Department of Biology, Faculty of Science and Technology, Mount Royal University, 
      Calgary, AB, Canada.
AD  - Department of Physiology, University College Cork, Cork, Ireland.
FAU - Zouboules, Shaelynn M
AU  - Zouboules SM
AD  - Department of Biology, Faculty of Science and Technology, Mount Royal University, 
      Calgary, AB, Canada.
FAU - Mann, Carli R
AU  - Mann CR
AD  - Department of Biology, Faculty of Science and Technology, Mount Royal University, 
      Calgary, AB, Canada.
FAU - Peltonen, Joel D B
AU  - Peltonen JDB
AD  - Department of Biology, Faculty of Science and Technology, Mount Royal University, 
      Calgary, AB, Canada.
FAU - Linares, Andrea M
AU  - Linares AM
AD  - Department of Biology, Faculty of Science and Technology, Mount Royal University, 
      Calgary, AB, Canada.
FAU - Chiew, Alexandra E
AU  - Chiew AE
AD  - Department of Biology, Faculty of Science and Technology, Mount Royal University, 
      Calgary, AB, Canada.
FAU - O'Halloran, Ken D
AU  - O'Halloran KD
AD  - Department of Physiology, University College Cork, Cork, Ireland.
FAU - Sherpa, Mingma T
AU  - Sherpa MT
AD  - Kunde Hospital, Khunde, Solukhumbu, Nepal.
FAU - Day, Trevor A
AU  - Day TA
AD  - Department of Biology, Faculty of Science and Technology, Mount Royal University, 
      Calgary, AB, Canada. tday@mtroyal.ca.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 142M471B3J (Carbon Dioxide)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - *Acclimatization
MH  - *Altitude
MH  - Carbon Dioxide
MH  - Humans
MH  - *Hypoxia
MH  - Nepal
MH  - *Oxygen
MH  - *Respiration
OTO - NOTNLM
OT  - Central chemoreceptors
OT  - High altitude
OT  - Hypoxic ventilatory response
OT  - Peripheral chemoreceptors
OT  - Steady-state chemoreflex drive
EDAT- 2018/10/26 06:00
MHDA- 2019/07/19 06:00
CRDT- 2018/10/26 06:00
PHST- 2018/10/26 06:00 [entrez]
PHST- 2018/10/26 06:00 [pubmed]
PHST- 2019/07/19 06:00 [medline]
AID - 10.1007/978-3-319-91137-3_2 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2018;1071:13-23. doi: 10.1007/978-3-319-91137-3_2.