PMID- 30359420
OWN - NLM
STAT- MEDLINE
DCOM- 20190401
LR  - 20190401
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 10
DP  - 2018
TI  - Ceruloplasmin, transferrin and apolipoprotein A-II play important role in 
      treatment's follow-up of paracoccidioidomycosis patients.
PG  - e0206051
LID - 10.1371/journal.pone.0206051 [doi]
LID - e0206051
AB  - Paracoccidioidomycosis (PCM) is a systemic disease caused by thermodymorphic 
      fungi of the Paracoccidioides brasiliensis complex, (Paracoccidioides spp.). 
      Patients with PCM reveal specific cellular immune impairment. Despite the 
      effective treatment, quiescent fungi can lead to relapse, usually late, the 
      serological diagnosis of which has been deficient. The present study was carried 
      out with the objective of investigating a biomarker for the identification of PCM 
      relapse and another molecule behaving as an immunological recovery biomarker; 
      therefore, it may be used as a cure criterion. In the evolutionary analysis of 
      the proteins identified in PCM patients, comparing those that presented with 
      those that did not reveal relapse, 29 proteins were identified. The interactions 
      observed between the proteins, using transferrin and haptoglobin, as the main 
      binding protein, were strong with all the others. Patient follow-up suggests that 
      cerulosplamin may be a marker of relapse and that transferrin and apolipoprotein 
      A-II may contribute to the evaluation of the treatment efficacy and avoiding a 
      premature decision.
FAU - Sylvestre, Tatiane Fernanda
AU  - Sylvestre TF
AUID- ORCID: 0000-0002-0023-964X
AD  - Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, 
      Botucatu, Sao Paulo-Brazil.
FAU - Cavalcante, Ricardo de Souza
AU  - Cavalcante RS
AD  - Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, 
      Botucatu, Sao Paulo-Brazil.
FAU - da Silva, Julhiany de Fatima
AU  - da Silva JF
AD  - Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, 
      Botucatu, Sao Paulo-Brazil.
FAU - Paniago, Anamaria Mello Miranda
AU  - Paniago AMM
AD  - Universidade Federal de Mato Grosso do Sul (UFMS), Faculdade de Medicina, Campo 
      Grande-Brazil.
FAU - Weber, Simone Schneider
AU  - Weber SS
AD  - Universidade Federal de Mato Grosso do Sul (UFMS), Faculdade de Medicina, Campo 
      Grande-Brazil.
AD  - Instituto de Ciencias Exatas e Tecnologia (ICET), Universidade Federal do 
      Amazonas (UFAM), Itacoatiara-Brazil.
FAU - Pauletti, Bianca Alves
AU  - Pauletti BA
AD  - Laboratorio Nacional de Biociencias-CNPEM, Campinas, Sao Paulo-Brazil.
FAU - de Carvalho, Lidia Raquel
AU  - de Carvalho LR
AD  - Universidade Estadual Paulista (UNESP), Instituto de Biociencia de Botucatu, 
      Botucatu, Sao Paulo-Brazil.
FAU - Dos Santos, Lucilene Delazari
AU  - Dos Santos LD
AD  - Centro de Estudos de Venenos e Animais Peconhentos (CEVAP), UNESP, Botucatu, Sao 
      Paulo-Brazil.
FAU - Mendes, Rinaldo Poncio
AU  - Mendes RP
AD  - Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, 
      Botucatu, Sao Paulo-Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181025
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Apolipoprotein A-II)
RN  - 0 (Transferrin)
RN  - EC 1.16.3.1 (Ceruloplasmin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Apolipoprotein A-II/*blood
MH  - Ceruloplasmin/*metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Paracoccidioidomycosis/*blood
MH  - Protein Interaction Maps
MH  - Recurrence
MH  - Transferrin/*metabolism
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC6201901
COIS- The authors have declared that no competing interests exist.
EDAT- 2018/10/26 06:00
MHDA- 2019/04/02 06:00
PMCR- 2018/10/25
CRDT- 2018/10/26 06:00
PHST- 2018/03/21 00:00 [received]
PHST- 2018/10/07 00:00 [accepted]
PHST- 2018/10/26 06:00 [entrez]
PHST- 2018/10/26 06:00 [pubmed]
PHST- 2019/04/02 06:00 [medline]
PHST- 2018/10/25 00:00 [pmc-release]
AID - PONE-D-18-08656 [pii]
AID - 10.1371/journal.pone.0206051 [doi]
PST - epublish
SO  - PLoS One. 2018 Oct 25;13(10):e0206051. doi: 10.1371/journal.pone.0206051. 
      eCollection 2018.