PMID- 30359727 OWN - NLM STAT- MEDLINE DCOM- 20190916 LR - 20231011 IS - 1095-9564 (Electronic) IS - 1074-7427 (Print) IS - 1074-7427 (Linking) VI - 156 DP - 2018 Dec TI - The effect of energy-matched exercise intensity on brain-derived neurotrophic factor and motor learning. PG - 33-44 LID - S1074-7427(18)30243-0 [pii] LID - 10.1016/j.nlm.2018.10.008 [doi] AB - BACKGROUND: Pairing a bout of high-intensity exercise with motor task practice can enhance motor learning beyond task practice alone, which is thought, in part, to be facilitated by an exercise-related increase in brain-derived neurotrophic factor (BDNF). The purpose of the current study was to examine the effect of different exercise intensities on BDNF levels and motor learning while controlling for exercise-related energy expenditure. METHODS: Forty-eight young, healthy participants were assigned to one of three groups: high-intensity exercise [High], low-intensity exercise [Low], or quiet rest [Rest]. The duration of the exercise bouts were individually adjusted so that each participant expended 200 kcals regardless of exercise intensity. BDNF was measured before and after exercise or rest. After exercise or rest, all participants practiced a 3-dimensional motor learning task, which involved reach movements made to sequentially presented targets. Retention was tested after 24-h. BDNF genotype was determined for each participant to explore its effects on BDNF and motor learning. RESULTS: All participants equally improved performance, indicated by a reduction in time to complete the task. However, the kinematic profile used to control the reach movement differed by group. The Rest group travelled the shortest distance between the targets, the High group had higher reach speed (peak velocity), and the Low group had earlier peak velocities. The rise in BDNF post-exercise was not significant, regardless of exercise intensity, and the change in BDNF was not associated with motor learning. The BDNF response to exercise did not differ by genotype. However, performance differed between those with the polymorphism (Met carriers) and those without (Val/Val). Compared to the Val/Val genotype, Met carriers had faster response times throughout task practice, which was supported by higher reach speeds and earlier peak velocities. CONCLUSION: Results indicated that both low and high-intensity exercise can alter the kinematic approach used to complete a reach task, and these changes appear unrelated to a change in BDNF. In addition, the BDNF genotype did not influence BDNF concentration, but it did have an effect on motor performance of a sequential target reach task. CI - Copyright (c) 2018 Elsevier Inc. All rights reserved. FAU - Baird, Jessica F AU - Baird JF AD - Department of Exercise Science, University of South Carolina, 921 Assembly St, Columbia, SC 29208, United States. FAU - Gaughan, Mary E AU - Gaughan ME AD - Department of Exercise Science, University of South Carolina, 921 Assembly St, Columbia, SC 29208, United States. FAU - Saffer, Heath M AU - Saffer HM AD - Department of Exercise Science, University of South Carolina, 921 Assembly St, Columbia, SC 29208, United States. FAU - Sarzynski, Mark A AU - Sarzynski MA AD - Department of Exercise Science, University of South Carolina, 921 Assembly St, Columbia, SC 29208, United States. FAU - Herter, Troy M AU - Herter TM AD - Department of Exercise Science, University of South Carolina, 921 Assembly St, Columbia, SC 29208, United States. FAU - Fritz, Stacy L AU - Fritz SL AD - Department of Exercise Science, University of South Carolina, 921 Assembly St, Columbia, SC 29208, United States. FAU - den Ouden, Dirk B AU - den Ouden DB AD - Department of Communication Sciences and Disorders, University of South Carolina, 915 Greene St, Columbia, SC 29208, United States. FAU - Stewart, Jill Campbell AU - Stewart JC AD - Department of Exercise Science, University of South Carolina, 921 Assembly St, Columbia, SC 29208, United States. Electronic address: jcstewar@mailbox.sc.edu. LA - eng GR - 15SDG24970011/AHA/American Heart Association-American Stroke Association/United States GR - T32 HD071866/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20181022 PL - United States TA - Neurobiol Learn Mem JT - Neurobiology of learning and memory JID - 9508166 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Biomechanical Phenomena MH - Brain-Derived Neurotrophic Factor/*blood/genetics MH - Exercise/*physiology MH - Female MH - Humans MH - Learning/*physiology MH - Male MH - Motor Skills/*physiology MH - Reaction Time/*physiology MH - Young Adult PMC - PMC6498427 MID - NIHMS1020369 OTO - NOTNLM OT - Acute exercise OT - Brain-derived neurotrophic factor OT - Exercise intensity OT - Motor learning EDAT- 2018/10/26 06:00 MHDA- 2019/09/17 06:00 PMCR- 2019/12/01 CRDT- 2018/10/26 06:00 PHST- 2018/04/20 00:00 [received] PHST- 2018/10/16 00:00 [revised] PHST- 2018/10/20 00:00 [accepted] PHST- 2018/10/26 06:00 [pubmed] PHST- 2019/09/17 06:00 [medline] PHST- 2018/10/26 06:00 [entrez] PHST- 2019/12/01 00:00 [pmc-release] AID - S1074-7427(18)30243-0 [pii] AID - 10.1016/j.nlm.2018.10.008 [doi] PST - ppublish SO - Neurobiol Learn Mem. 2018 Dec;156:33-44. doi: 10.1016/j.nlm.2018.10.008. Epub 2018 Oct 22.